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Lysergic Acid Diethylamide / LSD Antibody (need chemist knowledged comments)

drgreenthumb00

drgreenthumb00

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I came across some Lysergic Acid Diethylamide / LSD Antibody. At first I thought it was LSD.... Then i realized the LSD Antibody part. Then i noticed the size 50µl. I know very little about chemistry and volume and what not. Isn't this considered barely anything? I think I read somewhere that one dose of LSD = 50µl.

If a human was to take this would they still trip like LSD or LSD 25???

I'm curious as to whether or not you can trip with this chemical.
Product Type: Primary Antibody
Description: Sheep polyclonal to Lysergic Acid Diethylamide / LSD
Immunogen: Chemical / Small Molecule: LSD(1) conjugated to BSA.
Reacts with: Humans
Specificity: LSD Antibody recognises Lysergic Acid Diethylamide.
Tested Application: Competitive ELISA
Relevance: Lysergic Acid Diethylamide is an hallucinogenic drug that acts on the serotonin receptor, resulting in a powerful intensification and alteration of senses, feelings, memories, and self awareness for 6 to 12 hours.
Raised in: Sheep
Isotype: IgG
Purity: IgG fraction
Storage Buffer: Preservative: 0.09% Sodium Azide.
Constituents: 20mM Phosphate, 150mM Sodium chloride, pH 7.2.
Form: Liquid
 
drgreenthumb00 said:
I came across some Lysergic Acid Diethylamide / LSD Antibody. At first I thought it was LSD.... Then i realized the LSD Antibody part. Then i noticed the size 50µl. I know very little about chemistry and volume and what not. Isn't this considered barely anything? I think I read somewhere that one dose of LSD = 50µl.

If a human was to take this would they still trip like LSD or LSD 25???

I'm curious as to whether or not you can trip with this chemical.
Product Type: Primary Antibody
Description: Sheep polyclonal to Lysergic Acid Diethylamide / LSD
Immunogen: Chemical / Small Molecule: LSD(1) conjugated to BSA.
Reacts with: Humans
Specificity: LSD Antibody recognises Lysergic Acid Diethylamide.
Tested Application: Competitive ELISA
Relevance: Lysergic Acid Diethylamide is an hallucinogenic drug that acts on the serotonin receptor, resulting in a powerful intensification and alteration of senses, feelings, memories, and self awareness for 6 to 12 hours.
Raised in: Sheep
Isotype: IgG
Purity: IgG fraction
Storage Buffer: Preservative: 0.09% Sodium Azide.
Constituents: 20mM Phosphate, 150mM Sodium chloride, pH 7.2.
Form: Liquid
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dawg, you ain't gonna buy LSD online unless you got access to the right shiznit 8o. thats not even LSD, not sure what that is.
 
That's not LSD I think it's an antibody that binds to LSD. It says it's used as the primary antibody for a competitive ELISA which is a biochemical technique used to quantify the amount of antibody or antigen in a sample (which as it happens I learnt how to perform last week). In this case the antigen being quantified is LSD.
 
Sounds like an analytic chemical tool for companies analyzing samples of siezed drugs or doing research with LSD to me...

It would do nothing if ingested. If you injected it, it might block the effects of LSD. It might also kill you.

And ul is microliters. LSD doses are measured in ug, micrograms, and a "standard" hit is 100ug, though most in the US are less than that.
 
TheAzo said:
Sounds like an analytic chemical tool for companies analyzing samples of siezed drugs or doing research with LSD to me...

It would do nothing if ingested. If you injected it, it might block the effects of LSD. It might also kill you.

And ul is microliters. LSD doses are measured in ug, micrograms, and a "standard" hit is 100ug, though most in the US are less than that.
Click to expand...

God knows what would happen if it entered your body. As you rightly pointed out if eaten it would do nothing as stomach acid would denature it. I just skimmed over a paper on rabbit antibodies that bind to LSD and they aren't at all selective and will bind to various neurotransmitters which would cause all sorts of havoc so ingesting this is definately not a good idea.
 
I know its not real lsd .... I'm just trying to figure out what it is. On the site it said lsd if injested makes an individual trip for 6 to 12 hours. It was on a medical research chemical site
 
drgreenthumb00 said:
I know its not real lsd .... I'm just trying to figure out what it is. On the site it said lsd if injested makes an individual trip for 6 to 12 hours. It was on a medical research chemical site
Click to expand...

And LSD does make an individual trip for 6-12 hours.

That says nothing about what this material would do; it was just background information for people who don't know what LSD is (lol).
 
An antibody is the immune systems version of an antidote, in most cases they get it from animal blood from an animal exposed to something - most often a biological agent. One of the first vaccins if I am correct, was made this way only not taken from blood but pustule liquids.

It is however not sure that the reaction of a sheep's immune system produces something that adequately squelches / quenches the effects of LSD - checking the binding would be a quite important in vitro test. If it binds extremely well, chances are that LSD cannot act with it irreversibly attached to it.

I didn't know that immune systems of animals, including humans, think enough of LSD to produce an antibody but I also do not know enough about what triggers the system. I would think a toxic reaction is a good trigger, which LSD does not produce. If I were to make an LSD antibody perhaps I would administer LSD together with a substance that produces a toxic reaction to the sheep. It would probably be ethical to induce unconsciousness as well, and use the opportunity to increase the LSD dose. OK, going into ADD territory here.
(Also want to say that I recall 2C-B and possibly other 2C-X sometimes having a strange and probably immunogenic reaction like thick mucus in throat and other places - still like to know what is up with that)
 
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LSD 25 was the 25th attempt. The pustule was a really poor attempt for a vaccine years ago for small pox. What worked a lot better was the realization milk maids, who were exposed to cow pox, and got a slight rash on their hands, didn't get small pox. If a body recognizes something with an antigen sequence as non self cells, it will generate an immune response to compartmentalize it or destroy it. Someone may have found LSD generates an immune response in sheep, have isolated it, and are testing it to sell to people who don't want their kids doing acid. Best case here, you'll be vaccinated from getting high on LSD. Worst case, you'll be dead.
 
damnnnnn wow this is some good information. I tried reading a few medical reports about it online before I posted here. It was all jibberish to me. know you all made me understand what it was. I knew it wasn't LSD. Definitely almost bought it too. that would have sucked
 
An antibody is a protein produced by the immune system upon exposure to a virus or bacteria. The antibodies bind to the antigen and stimulate T-cells to grow and attack the invading pathogen. LSD is a small molecule and will not elicit antibodies. However, it could be conjugated to a protein and injected to make antibodies. Once I helped someone make a conjugate of ergonovine with albumin to immunize cattle against ergot infestation of tall fescue. As far as I know, it worked. Antibodies against LSD will not vaccinate you--you need the antigen.
 
Without being conjugated to BSA there probably wouldn't be antibody binding. I'm pretty sure that BSA is able to bind to some molecules containing diethylamide groups as I know for a fact (as shown by my research group) that it as well as human and rat serum albumin binds to some fluorescent chromophores containing diethyl and dimethyl amino group.

So the immune response is towards BSA/LSD complex...not LSD alone. But yar for elisa.
 
I would think that this "LSD Antibody" has nothing to do with making you "immune" to LSD and her sisters and much more to do with drug detection:

http://en.wikipedia.org/wiki/Immunoassay

Quote from the Wikipedia Article:
An immunoassay is a biochemical test that measures the presence or concentration of a substance in solutions that frequently contain a complex mixture of substances. Analytes in biological liquids such as serum or urine are frequently assayed using immunoassay methods. Such assays are based on the unique ability of an antibody to bind with high specificity to one or a very limited group of molecules.
Click to expand...

I could be very wrong about this but it looks to be the most logical answer.
 
elessdee said:
could this in your system have any effect on long term HPPD?
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hypothetically, if this is some kind of vaccine (which i highly doubt), this would do nothing to treat HPPD as HPPD is a mental disorder and while it may be cause by a bad acid trip, is irrelevant to LSD as a chemical.

If it deactivates LSD molecules, it could also prevent HPPD from occurring as a result of taking LSD because HPPD is triggered by the traumatic events resulting from a trip (which would be averted).
 
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