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lurasidone (aka Latuda) - killed a psychosis better than anything i've tested

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yoyoman

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Jun 11, 2006
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A friend gave me several sample packets of these 40&80mg pills.

I took one 40mg a day just to see if i noticed anything good, nope, but also didn't notice anything...nothing at all - weird for an antipsychotic (i usually expect to be tired, groggy etc). So i just skipped a day with no plan to use them again.

Well one night after doing alpha-ppp all day at work (w/benzo's), came home did a bunch of methylone...400ishmg total, plus snorted some 4-aco-dmt. This was after only getting 3 hours of sleep the night before.

All the psychotic stuff started happening, the shadows and things moving around, or glasses empty and then fill up again etc. Bizarre trip... it was cool only because i was on phenazepam.

But when I was done with it, took one 40mg lurasidone, and 50 minutes later BAM, all psychosis totally gone - as if the pill reversed the effects of sleep deprivation. I'd say its a great one to have around if your in some kind of stim (or not) psychosis... no side effects which is odd i always expect side effects with these meds.

lurasidone does some odd stuff like antagonize 5ht7, 5ht1a etc.

----

I have taken anti-psychotics to try to cancel trips.. but with this, it was just like BOOM, gone, like normal brain functioning.

What do you all think about lurasidone? Just the total lack of side effects was the part that got me to even take the samples to try out.
 
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This is a rather pointless discussion post. What exactly are you expecting to get? "Oh yeah, this niche antipsychotic is... a great antipsychotic! I agree!"
 
He wants speculative discussion on why this anti-psychotic, moreso than others both typical and atypical, lacks unpleasant side-effects.

ebola
 
I would imagine the relative efficacy of this drug is due to the degree of selectivity.
Lurasidone acts as a D2 (Ki = 0.994 nM), 5-HT2A (Ki = 0.47 nM), 5-HT7 (Ki = 0.495 nM), and α2C-adrenergic (Ki = 10.8 nM) receptor antagonist, and 5-HT1A (Ki = 6.75 nM) receptor agonist.[4] It has only weak or negligible actions at the 5-HT2C, α1-adrenergic, H1, and mACh receptors.[4]
Click to expand...

5-HT1A agonism is a known source of anxiolysis, and the blockade of D2/HT2A/a2C should act as a general 'sedative', calming your thoughts... 5-HT2a and a2C agonism is a hallmark of psychedelic agents like mescaline, and D2 agonists increase impulsivity.

The lack of H1/mACh activity is probably the reason you don't get 'dopey'. Drugs like seroquel hit the histamine system quite a bit, causing drowsiness.
 
If I may, I would just like to add that no side effects (unpleasant) surprises me as well. But what is so different is that I am alive and not "gone" as these types usually do. I actually feel like reading up on it. I don't know, the docs know there 's a 50 mcg. fentanyl patch on my arm. Beats the hell out of me. I am 60 years old, too. Tomorrow they're pushing 60 mg. on me. I wonder. . .
 
Sounds like a useful one to have around for anyone experimenting with stims or psychedellics.
 
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