LSD, MDMA, 2CT2 Combo

[Coolio]

I thought the observed symptoms were hypothermia and shock?

 

[swilow]

Hmm, I'm thinkin this dilemma probably solved itself 5 years ago....:D

 

[PepperSocks]

Yeah p-mo seems just fine.

 

[jamaica0535]

so 2c-x might be a mild MAOI?

interesting, but in a way by my experiences combining MDMA and 2c-i it makes a little sense....

When 10mg of 2c-i and 1 clean roll can have you laid out for hours immersed in fractals and melting into whatever your laid out in, it seems a little more possible that these 2 potentiate instead of just a great synergy....

 

[Solipsis]

Well, technically every thing eaten bij MAO inhibits it and so do all 2C-Xs. But that's only a little and really when someone talks about a MAOI its a somewhat stronger inhibitor.
Halo-substituted 2C-Xs like 2C-I would be pretty mild in that respect and I think synergy is based on much more than MAO occupation.

No there was talk about thioalkylated 2Cs so thats several 2C-T-Xs that have MAOI properties that make combining it with monoamine releasers a bad idea...

P.S. was it hypothermia and shock then? i must have been mistaken

 

[kezertamine]

i wish i could send you a video of when i took 2ct2 with mdma and flipped out blacked out and had my legs taped together with ducktape.. by the way duck tape sucks when left on your legs for a long period of time while sweating balls and puking your guts out yellin about dying... for real stay away from 2ct- anything combos.. do those alone.. as far as 2ce .. i mixed that at high doses with mdma with no problem and loved it... 2ct- x drugs are biologicaly unstable at a metabolic level with amphetamines and or seratonin drugs... mdma alone is an amphetamine based molecule.. i strongly advice against your mixture.. as far as mdma and lsd.. that is fun

 

[Recept]

^ It's not the amphetamine part in MDMA that makes it dangerous to combine with 2C-T-x. It's the fact that it's a monoamine releaser. That combined with MAOI properties of 2C-T-x can result in dangerously high serotonin levels in the synapses, potentially bordering on serotonin syndrome.

How much of each substance did you take BTW? If it was relatively high dose of 2C-T-2, no wonder you had this reaction. At low doses, 2C-T-x probably don't have very significant MAOI properties and could be combined safely with MDMA, however best to err on the side of caution and stay away from combos like this altogether.

 

[Solipsis]

Yeah that's also what I thought, but now there are people wondering about the evidence for this kind of statement. If you ask me it's fairly evident that 2C-T-x's make a lousy combination with certain other substances but can we say with certainty that the mechanism is 'potentiated' monoamine release leading to possible serotonin syndrome? I wonder as well.
I know I've suggested before what could lead people to believe we are talking about MAOI risk but that was about what incidents looked like and not what they actually are.
Please read this and check out the Erowid Sulphurous Samadhi article altogether...
I'm not saying anything for truth but realize that there is so much unclear about the workings of drugs and psychedelics in particular that when someone forms a theory for lack of alternative information this theory can be copied over the internet through quote after quote much faster than the theory is proven - and then it is already taken as validated evidence.
Just saying, we know less than we like to believe.

 

[PepperSocks]

If you ask me it's fairly evident that 2C-T-x's make a lousy combination with certain other substances but can we say with certainty that the mechanism is 'potentiated' monoamine release leading to possible serotonin syndrome? I wonder as well.

I guess things affect different people differently but IME 2C-T-2 combines with MDMA beautifully in much the same way as 2C-B; with the same physical effects of that combination; which has been used countless times. All I'm saying is I can't find any basis on the MAOI theory of 2C-T-x's. Even the academic researchers have used this combination with great results. Maybe some people are just sensitive. If that's the case these people who report nasty effect from a 2C-T-x with MDMA combination would likely get the same reaction had they used 2C-B instead.

 

[Solipsis]

Well sure, but if you find synergy in the combination that could also be an effect of the potentiation. Maybe there are tons of people who experience the combination as nothing more than a strong experience but what we're dealing here is also a potentiation of possible negative effects. I know of people who died of MDMA alone, you can react really badly.
What I personally believe in is the possibility that 2C-T-x's increase this risk because they have a bigger load, not much more actually. I'm sceptical about MAOI as a mechanism as well, but I still wonder what the hell went wrong with those 2C-T-7+MDMA deaths and prefer to avoid such combinations as a precaution.
We're dealing with substances that are less investigated than we would like, there's no need to tempt fate.

 

[CRICKETBEE]

2ct2 and 2cb?

Does anyone have any information on taking 2c-t-2 with 2c-b? or acid?

I generally like to throw something in at about the 5 hour mark and I was wondering if acid or 2c-b have an mono amine releasing properties like MDMA?

i have found 2c-b to combine well with almost everything so this is why i mention it.

or i guess i could just take more 2c-t-2 at 5hrs

thanks