LSD and Serotonin

[LimaZ]

Hey all..

Ok, simple question.. Does LSD release the same quantity of serotonin than MDMA?

 

[Bsiren]

To my knowledge LSD "attaches" to serotonin, rather than releasing it. This is why candyflipping is so much fun- they both act on the 5-ht system in fun and different ways.

This is something the psychedelic forum will have more info on, I'm not very informed on LSD, and they will likely give you a better answer, and correct my above statement.

 

[IamMe90]

LSD does not release serotonin.

 

[sekio]

LSD is a serotonin agonist that mimics the effect of serotonin at your brain cells but can produce a greater "activation" than serotonin alone.

As a side effect of binding to some serotonin receptors, LSD can cause serotonin release in some parts of the brain, but itt is not a direct releasing agent like MDMA. SO the answer to your question seems to be no.

 

[wiffz]

theres a text on this on dmt-nexus

its an enigma to me

https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=910

first few sentences:

LSD and Serotonin The following is an attempt to correlate seeming unrelated material into a meaningful whole. The goal is to synthesize information gathered about the pineal gland, the psychopharmacological molecule LSD, and the neurotransmitter serotonin. There have been detailed studies done on each one of these subjects. For instance, there are volumes of work and research done on the molecule LSD; the pineal gland has been studied extensively; and even the hormone serotonin has had its day in the lab. But there are few studies which have brought together this three-fold relationship. This paper involved a great amount of research. It is the result of manipulating many manuals, texts, and magazines published by the lay and the respectable

 

[38slug]

NO NO NO Lsd is a much higher release of dopamine!

 

[Fyasko.]

it just binds to the 5HT receptors i think.

 

[LimaZ]

So MDMA make more damage at the 5HT receptors?

 

[Fyasko.]

i know that they both downregulate 5ht receptors,
not sure which one does more damage.

but it would depend on the frequency of use,
if they're getting actual MDMA, etc.

 

[atara]

It's called Mouse Party, and it's a total oversimplification of things but for now it's accurate enough:

http://learn.genetics.utah.edu/content/addiction/drugs/mouse.html

LSD is an agonist at the receptors 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht6, D3, and D4, as well as several others with lower affinity.

MDMA is a serotonin releaser and dopamine releaser and is metabolized into MDA, which is a significantly less potent serotonin releaser, slightly more potent dopamine releaser, and also an agonist at 5-ht1a, 5-ht2a and 5-ht2b.

In short: LSD binds to serotonin and dopamine receptors. MDMA binds to serotonin receptors and also acts as a releasing agent of dopamine, serotonin, and norepinephrine.

 

[38slug]

it's called mouse party, and it's a total oversimplification of things but for now it's accurate enough:

http://learn.genetics.utah.edu/content/addiction/drugs/mouse.html

lsd is an agonist at the receptors 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht6, d3, and d4, as well as several others with lower affinity.

Mdma is a serotonin releaser and dopamine releaser and is metabolized into mda, which is a significantly less potent serotonin releaser, slightly more potent dopamine releaser, and also an agonist at 5-ht1a, 5-ht2a and 5-ht2b.

In short: Lsd binds to serotonin and dopamine receptors. Mdma binds to serotonin receptors and also acts as a releasing agent of dopamine, serotonin, and norepinephrine.

thats a really great link

 

[Humboldt]

Isn't it kinda combined agonist/releaser for serotonin and dopamine? I mean, take a look at the structure: there's nearly every known serotonin/dopamin-releaser/agonist-like structure partially included in the LSD molecule...