LSD and nausea

[frontbluntt]

So I've done just about every psychedelic in the book besides LSD. Finally found some real Lucy (I think).
Tripping is my favorite thing to do, but many psychs come with nausea and having kind of a weak stomach this can completely ruin entire substances for me.
For example, the best trips of my life have been on 2C-E, but I just couldn't keep doing it due to horrendous three-hour come ups full of nausea.

To make matters worse I never actually puke, even if I try and gag myself I can't make myself puke, so I just remain nauseous.

I get nauseous until the peak on mushrooms but it is just bareable due to the short length of time it affects me.
The 2Cs ravage me, all but 2C-C have made me want to cry on the come-up, and even on 2C-C I felt a little sick.
Even the NBOMEs make me uncomfortable.
nd as far as the RC tryps, they used to not make me sick at all, but these days I get very uncomfortable on the come-up and have stopped taking them.



Anyways, my question is how bad is LSD nausea relative to these compounds, and how long does it last?

P.S.- I have access to ondansetron, various benzos, ginger root extract, and weed (although I dislike smoking weed). If any of these will help without affecting the trip, that would be great.

 

[Help?!?!]

Shit mang! Eat some Ondan and it will 100% eliminate any nausea! LSD has only ever made me vomit once out of nearly hundreds of trips with it but there were also some circumstances behind it. I'm one of the people who pretty much finds LSD to be the perfect psychedelic, the come up is virtually non-existent in terms of side effects and the trip is always amazing without any anxiety. For me personally its incredibly rare for the nausea psyches produce to outlast the come up, its happened but even then it only really lasted an hour or so past it and was probably agitated by the fact that I would try to eat something light out of hunger. Terrible that you have Ondansetron around and you've made yourself suffer through the nausea when you didn't need to at all.

BTW its a 5HT3a agonist so it won't have any effects on the trip.

 

[EarthBounded]

Typically LSD will be described as having less nausea than other psychedelics such as Mescaline, Psilocybin, LSA and plenty more. I agree with Help the come up is is virtually non-existent with negative side effects.

Cannabis and Ginger root extract will help, I am unfamiliar with Ondan gonna look it up now.

 

[frontbluntt]

Shit mang! Eat some Ondan and it will 100% eliminate any nausea! LSD has only ever made me vomit once out of nearly hundreds of trips with it but there were also some circumstances behind it. I'm one of the people who pretty much finds LSD to be the perfect psychedelic, the come up is virtually non-existent in terms of side effects and the trip is always amazing without any anxiety. For me personally its incredibly rare for the nausea psyches produce to outlast the come up, its happened but even then it only really lasted an hour or so past it and was probably agitated by the fact that I would try to eat something light out of hunger. Terrible that you have Ondansetron around and you've made yourself suffer through the nausea when you didn't need to at all.

BTW its a 5HT3a agonist so it won't have any effects on the trip.

I only just recently have acquired access to it, so I've yet to try it with a psych.
Great to know it won't affect the trip!

 

[xx001]

For me, lsd is the ideal psychedelic in terms of its side effect profile. It is the most physically gentle psychedelic I have used. It gives me no nausea and usually doesn't even interfere with my appetite. (weed helps here though)

2c-c and 2c-e are great fun but both have made me vomit in the past, though taking the 2c-c on a full stomach was not the wisest decision I have ever made.

I have never used ondansetron, but, from my understanding, it would be excellent for helping with nausea from psychedelics, though with lsd, I don't see why it would be necessary.

 

[EarthBounded]

OP it seems you are just more prone to GI disturbances then then regular tripper. I would still go with Ginger root and Cannabis. Ondan seems like it has a correct use in this world and using it for tummy aches on tripping does not seem like the proper use. Trip on a very light or empty stomach, lay down for the beginning until you are sure you wont be nauseous

 

[Help?!?!]

Ondan seems like it has a correct use in this world and using it for tummy aches on tripping does not seem like the proper use.

Ha, how so? Nausea is a side effect of taking psychedelic drugs similarly to side effects from other things just because one can be a choice does not mean one should suffer through it due to that. Thats a bit of lunacy. This comes from a person who spent more time vomiting on psychedelics than the average as well. Theres no good reason to subject yourself to that if you don't have to, vomiting causes esophageal erosion amongst other things and while obviously it shouldn't happen often enough for that to occur, its still no reason to subject yourself to the possibility of it. Ginger for some is not an adequate anti-emetic while a dose of Ondan will completely obliterate the possibility of any nausea at all. I agree that fasting beforehand and laying down are the way to go but even then sometimes its simply not avoidable. With a solid dose of Ondan you could eat a large meal and it really wouldn't matter to much which in my mind is probably better because then you don't have to worry about eating later. All personal preference really though!

 

[IamMe90]

OP it seems you are just more prone to GI disturbances then then regular tripper. I would still go with Ginger root and Cannabis. Ondan seems like it has a correct use in this world and using it for tummy aches on tripping does not seem like the proper use. Trip on a very light or empty stomach, lay down for the beginning until you are sure you wont be nauseous

The "correct" use of ondansetron is to alleviate nausea. It is a well tolerated drug with a remarkably minimal side-effects profile and there is no reason why someone who experiences above-average gastrointestinal discomfort during trips (which can be crippling for some, myself included) shouldn't use what's available to mitigate those nasty effects. Ginger and cannabis don't work for everyone, by the way.

 

[frontbluntt]

The "correct" use of ondansetron is to alleviate nausea. It is a well tolerated drug with a remarkably minimal side-effects profile and there is no reason why someone who experiences above-average gastrointestinal discomfort during trips (which can be crippling for some, myself included) shouldn't use what's available to mitigate those nasty effects. Ginger and cannabis don't work for everyone, by the way.

Yeah I've taken ginger a lot but if it helps at all, it's unnoticeable.
And weed can sometimes just amplify the feeling.
Looking forward to trying ondansetron with various psychs, it sounds like its something that will work no matter what, instead of varying from person to person.

 

[IamMe90]

To answer your question in the OP though, LSD is remarkably light on the body and has only made me throw up once at very high doses. I've also taken it conjunction with fairly high doses of 2c-i and 2c-e, drugs that often make me throw up on their own, without serious nausea (although obviously I wouldn't recommend trying this out if you're not prepared for the worst).

 

[EarthBounded]

All personal preference really though!

Exactly! I agree with that but here is what I dug up on Wikipedia...

"A 2006 double-blind, randomized controlled trial indicated that ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol.[4] An earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms"

"Constipation, dizziness and headache are the most commonly reported side effects associated with its use"

I posted the Schizophrenia material because this could interact with the trip both positive and negatively. Just because it will get rid of the stomach ache temporarily doesn't mean its some perfect remedy.

Anyone who has successfully used Odan over and over with LSD feel free to chime in and tell me im wrong... I am new to learning about this however all drugs carry side effects that why I was quick with my response earlier.

Like help said it is personal preference.

OP do you have any pre existing GI problems, have you ever seen a doctor about it?

In spirit of Harm Reduction I would let a doctor tell me if I need Odan or not, you could develop side effects without even realizing it.

 

[IamMe90]

Exactly! I agree with that but here is what I dug up on Wikipedia...

"A 2006 double-blind, randomized controlled trial indicated that ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol.[4] An earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms"

"Constipation, dizziness and headache are the most commonly reported side effects associated with its use"

I posted the Schizophrenia material because this could interact with the trip both positive and negatively. Just because it will get rid of the stomach ache temporarily doesn't mean its some perfect remedy.

Anyone who has successfully used Odan over and over with LSD feel free to chime in and tell me im wrong... I am new to learning about this however all drugs carry side effects that why I was quick with my response earlier.

Like help said it is personal preference.

OP do you have any pre existing GI problems, have you ever seen a doctor about it?

In spirit of Harm Reduction I would let a doctor tell me if I need Odan or not, you could develop side effects without even realizing it.

I have used ondansetron with many psychedelics repeatedly with absolutely no interaction with the psychedelic effects at all. There are many reported uses of ondan with psychedelics. It's primary action is on 5ht3a which isn't responsible for mediating psychedelic action.

The parts you left out from the wiki: "Ondansetron is a well-tolerated drug with few side effects... There have been no significant drug interactions reported with this drug's use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system."

Really, it's a standard anti-emetic in the medical community. I don't think there's any more reason to worry about taking ondansetron than taking any other relatively little-researched drugs like the various RCs we all take here (which happen to be far less researched).

 

[frontbluntt]

Exactly! I agree with that but here is what I dug up on Wikipedia...

"A 2006 double-blind, randomized controlled trial indicated that ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol.[4] An earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms"

"Constipation, dizziness and headache are the most commonly reported side effects associated with its use"

I posted the Schizophrenia material because this could interact with the trip both positive and negatively. Just because it will get rid of the stomach ache temporarily doesn't mean its some perfect remedy.

Anyone who has successfully used Odan over and over with LSD feel free to chime in and tell me im wrong... I am new to learning about this however all drugs carry side effects that why I was quick with my response earlier.

Like help said it is personal preference.

OP do you have any pre existing GI problems, have you ever seen a doctor about it?

In spirit of Harm Reduction I would let a doctor tell me if I need Odan or not, you could develop side effects without even realizing it.

This quote only says it affected negative schizophrenia symptons (loss of affect, catatonia, etc) and not positive symptoms (hallucinations) so hopefully that points to a trip being unaffected.

And no I don't think I have any serious GI problems, I just get nauseous more easily from drugs and especially alcohol than the average person.

 

[Help?!?!]

Don't bother, TBH I only posted that because i've seen Earthbounded post against use of other things as well and I don't think people need to suffer needlessly and all that(don't worry EB nothing against you at all brother/sister !). BTW there are a huge number of chemicals that will say excessively similar things, most 5HT agonists/antagonists have portions that help with schizophrenia/other mental disorders, it does not mean much of anything really...unless your effected by schizophrenia in which case you should clearly not be consuming psychedelic chemicals anyways. I've never noted a single side effect from Ondan and when i've done one of my ridiculous combos, at times i've taken up to 16mgs to absolutely ensure no nausea would be present and I felt absolutely zero side effects as Iam also stated. FB, don't worry about GI problems, when you've got them their obvious, i've had ulcers before and might have one currently, you'd know most times if something was actually wrong with your GI system. Randomly psychedelics are really the only thing that usually has assured nausea but even then that can be totally random, sometimes i'll dose say 20-30mgs of 2c-e and feel absolutely fine whilst other times i'll puke multiple times or feel nauseated for the length of the come up, one reason I enjoy have Ondan around.

EB, do you know a lot about pharmacology? While at times with extended use you can form new or worsening side effects from drugs, Iam posted an important bit, which tells you Ondan is highly accepted by almost all portions of the population. When you look at most other anti-emetics, this normally isn't the case. They'll either have more adverse effects or not work as efficiently for nausea as Ondan or other 5HT3a agonists. I've never tried Granisetron or Tropisetron, I bet their not to bad either. I wanted to try Graniestron due to its elongated HL and lowered dose but allowed a friend in need to use it instead. They reported pretty much non-existent side effects and absolutely stellar anti-emetic properties.

I know I said it before as did Iam, but Ginger only works very effectively for some people where as Ondan/other 5HT3a agonists do not fuck around. If I have at least 8mgs, I would eat a three course meal before munching down the most nauseating psychedelic, thats how well it works! If ginger root works that way for you....i'm jealous and more power to ya, but noids and the root do not work for me, or if they do its a gamble whereas Ondan/etc are not at all.

 

[EarthBounded]

Don't bother, TBH I only posted that because i've seen Earthbounded post against use of other things as well and I don't think people need to suffer needlessly and all that(don't worry EB nothing against you at all brother/sister !). BTW there are a huge number of chemicals that will say excessively similar things, most 5HT agonists/antagonists have portions that help with schizophrenia/other mental disorders, it does not mean much of anything really...unless your effected by schizophrenia in which case you should clearly not be consuming psychedelic chemicals anyways. I've never noted a single side effect from Ondan and when i've done one of my ridiculous combos, at times i've taken up to 16mgs to absolutely ensure no nausea would be present and I felt absolutely zero side effects as Iam also stated. FB, don't worry about GI problems, when you've got them their obvious, i've had ulcers before and might have one currently, you'd know most times if something was actually wrong with your GI system. Randomly psychedelics are really the only thing that usually has assured nausea but even then that can be totally random, sometimes i'll dose say 20-30mgs of 2c-e and feel absolutely fine whilst other times i'll puke multiple times or feel nauseated for the length of the come up, one reason I enjoy have Ondan around.

EB, do you know a lot about pharmacology? While at times with extended use you can form new or worsening side effects from drugs, Iam posted an important bit, which tells you Ondan is highly accepted by almost all portions of the population. When you look at most other anti-emetics, this normally isn't the case. They'll either have more adverse effects or not work as efficiently for nausea as Ondan or other 5HT3a agonists. I've never tried Granisetron or Tropisetron, I bet their not to bad either. I wanted to try Graniestron due to its elongated HL and lowered dose but allowed a friend in need to use it instead. They reported pretty much non-existent side effects and absolutely stellar anti-emetic properties.

I know I said it before as did Iam, but Ginger only works very effectively for some people where as Ondan/other 5HT3a agonists do not fuck around. If I have at least 8mgs, I would eat a three course meal before munching down the most nauseating psychedelic, thats how well it works! If ginger root works that way for you....i'm jealous and more power to ya, but noids and the root do not work for me, or if they do its a gamble whereas Ondan/etc are not at all.

Fair enough, I thoroughly read this and agree. I am guessing I am just being biased here, I get bad nausea with psychedelics but I guess I just need to learn that some have it way worse, I guess if I had a serious GI disorder I would consider it too.

I am going to research this more I have never seen or heard of it or seen anyone use it in years of being in the scene, that is why I jumped to deny it.

Cheers Help I appreciate the knowledgeable response, this still isn't a method I would recommend , maybe with time and research.

Well OP I have had people close to me with severe GI problems, one was even Diagnosed with IBS and possible Chrons last year, she threw up every morning and night. She had no problems with LSD and/or was always able to power through it, I tripped with her on multiple occasions and she was fine.

 

[Help?!?!]

Well EB I've seen you denounce synthetics before, and 100% not to offend but the only people who do this are almost always normally ignorant of pharmacology and only understand it to certain depths(you seem like a terribly bright fellow/lady though! Just opinionated which in never a bad thing ). Everything works the same in certain manners regardless of whether it was naturally derived or a molecule thought up off a natural one, they all work on the same receptors. I won't be an idiot enough to claim that some of the natural remedies are the best routes, because they truly are! The only downfall is that for some people such as myself, they don't don't work as well as they do for others so for me personally things like Ondan are a god send. Like for example, I don't mind fasting for a psychedelic trip like 2c-E or 2c-P where I know its best to just not eat or eat very lightly 6-12 hours previous to the dose, but I also know its not the best idea to use strongly acting chemicals while at a caloric deficet at any time. With Ondan like stated before, at the right dose you could eat the most fulling, disgusting thing you could imagine and nausea wouldn't even be a worry....

Lol either way EB, Iam, As, and I are still on the same page though that LSD really causes few to no side effects, especially GI ones. Personally if your really worried, I would say this, either fast for around 6-12 hours or eat a light meal 6-12 hours before and preload with a fair bit of Ginger root, I may never have found it totally effective but it really does reduce nausea, it just may not fully take it away if your in a bad run. Then if during the come up your feeling uneasy GI wise, slowly smoke some MJ, I would advise really toking it but you said its not really your thing to much.


Either way the important thing is.....don't worry about it! To much worry will only lead to bad things, i'm sure as long as you take the right precautions, and with all this advice you'll have splendid time!