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LSD and MAOI's

From my loft status I think LSD is overated- but do we really need to potentiate something active at 20ug...I don't think so.
 
MAOI's are somewhat psychedelic in their own right AFAIK, although i'm not sure how, doesn't seem to make much sense to me because if it were just just elevated levels of 5-HT that produced htr-2A type visuals, then *shrug* lots of drugs that elevate 5-HT levels should produce them.
But no it shouldn't boost the effects of LSD because AFAIK LSD is not metabolized by MAO, so inhibiting MAO shouldn't have any effect.
HOWEVER
IF high levels of 5-HT are in themselves (even mildly) psychedelic then we could expect to see a synergy between this and LSD's action.
 
MAOIs as such aren't psychedelic, it's just that some drugs with heavy MAOI properties (such as harmine and harmaline) are psychedelic.

Ok obviously "potentiate" isn't the word for this kind of interaction, but there seems to be some sort of synergy (perhaps a secondary cascade effect, or how exactly would one call it?) between LSD and MAOIs.

Personally, I don't see much advantage in combining LSD with MAOIs either, but different strokes for different folks I suppose.

And I wouldn't say LSD is overrated, just a little too hyped up I guess. It really is a wonderful substance, it's not really capable of anything some other substances couldn't do, but at the same time it can offer a wide range of various effects. It is a wonderful tool for exploring the mind and the subconscious, but it's not superior to all other psychedelics, contrary to the popular belief.
 
Are you sure? I seem to remember that people report sparkling of the vision and minor geometric patterns and the like with selective MAOIs.
Actually, now that I think of it, i'm pretty sure the same effects are noted in heavy Serotonin Syndrome too! Perhaps 5-HT IS psychedelic in it's own right, but only noticeably so at such concentrations that it is dangerous- BUT enough to give a synergy when you've taken another psychedelic.
(Above is unsubstantiated ramblings, my 0.02 thrown in from the top of a ferris wheel)
 
Well, any kind of inbalance in brain chemistry may cause distortions in how we perceive reality, the most obvious example that comes to mind being DA psychosis. It is definately possible that inproper levels of 5-HT may cause similar symptoms as well.
 
Have many other people tried this combo?
I just recently found some L and have some Syrian Rue that I'm thinking of combining with it
oh and also smoked DMT

Just wondering if anyone has something to add about the combo?

edit:: ohh, Might have been better resurrecting the thread on this in psych discussion
 
Ness said:
I would also like to know how much it changes the character of the trip. I know that's subjective, but even generalizations would be nice.
Click to expand...

are you talking about the psychedelic MAOIs like harmaline, or less interesting things like selegililine?
 
Good question,
personally I've tried mushrooms and harmala, which was deep and interesting but not something I wish to repeat. Acid and heavy MAOIs seems like a pretty bad idea, and I'm not interested in ideas like combining LSD with like harmaline.
But what about mild ones that are suspected to have MAOI properties like passion flower? Seems to me that when you could use a boost during acid but for whatever reason don't want to smoke dope these kinds of herbs that normally produce a little too weak effects to really notice could be effective?
 
Yea I've done Mushies and Harmala many times and it has become by far one of my favorite combinations
I was thinking I'll just start with a very small dose of the Syrian Rue and see where that brings me before bringing in the DMT
 
Solipsys said:
Good question,
personally I've tried mushrooms and harmala, which was deep and interesting but not something I wish to repeat. Acid and heavy MAOIs seems like a pretty bad idea, and I'm not interested in ideas like combining LSD with like harmaline.
But what about mild ones that are suspected to have MAOI properties like passion flower? Seems to me that when you could use a boost during acid but for whatever reason don't want to smoke dope these kinds of herbs that normally produce a little too weak effects to really notice could be effective?
Click to expand...


Passionflower contains harmaline
 
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