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LSD and MAOI's

I would also like to know how much it changes the character of the trip. I know that's subjective, but even generalizations would be nice.
 
willow11 said:
To what degree do MAOI's potentiate LSD? I have heard that it doesn't and that it does....
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By alot!

what are the effects of LSD? its ahrd to explain, just as teh effects of LSD and MAOis are hard to explain, its one of those things you got to do to understand!



Iv done it quite a few tiems, as well as combining them with other lysergic acids.


ALL have potentiation!
 
Oh, it chages it in head space (mroe spaced out and self analytical) and mroe geometric type visuals rather then acid washed type visuals. Also extends the durration.


as Is aid, if you feel rbave and know about maoi's then do it! thats teh only real way to understand!
 
Okay, so how can you say that you have potentiation, when you are dealing with 2 psychedelic drugs together. Youkai, I believe what you may be experiencing is synergy! I have a wonderful thread about this in TR, also a wonderful article that talks about it. I say that MAOis dont really potentiate psychedelics in the sense of the definintion of potentiate. Possibly to an extent non subsituted tryptamines, but not others, and defiantely not Lysergic Acid Compounds!
 
It potentiates things quite a bit-

I was just talking about this to a friend who has done quite a bit of LSD-

He said it made things much more 'animal-like'

He also strongly recommended LSD+DMT+MAOI to me as a peak experience
 
samadhi_smiles said:
It potentiates things quite a bit-

I was just talking about this to a friend who has done quite a bit of LSD-

He said it made things much more 'animal-like'

He also strongly recommended LSD+DMT+MAOI to me as a peak experience
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Been there. <3 ;)
 
Beenhead said:
http://www.maps.org/news-letters/v06n3/06332ott.html

Check that over

You cant just go off of experience reports with this, there is no way of knowing whether what you feel is actually potentiation, or synergy, or just expectations! We gotta have some science!
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well, teh synergy of it potentiates it. Requires less material for a higher "high".

but take the same amterial and HOLD ON!!!!



MAOIS DO make for a mroe intence trip then LSD gievs alone, and changes the nature in visuals and head space (also in body high).
 
Yes I am sure they do, but because you are combining psychedelics like Candyflipping. But it is not Potentitation: TO render one drug more potent. In other words To increase the Bio Availability of. MAOi s do not increase the BioAvailability of LSD. Read the study, it is much smarter than I am.

All im saying is we should make a clear and less misleading distinction betweens synergy of two substances and potetntiation.
 
Am I right in saying that LSD is not a monamine, and therefore should pass through the stomach unscathed?

Youkai, have you used MAOI's alone? If you subtracted those effects from typical LSD effects would you say your combo was because the LSD was MAO-inhibited, or because the two drugs were working their effects together (what beenhead said in other words). ?

I have read too many things saying that inhiniting MAO shouldn't increase LSD EFFECTS.
 
Im almost positive that monoamine just means a primary amine, in that case no LSD is not a Primaryamine, but DMT is not either DMT is a Tertiary Amine, Meaning the amine is connected to three carbons 2 Me's and a ethyl indole
 
willow11 said:
Am I right in saying that LSD is not a monamine, and therefore should pass through the stomach unscathed?

Youkai, have you used MAOI's alone? If you subtracted those effects from typical LSD effects would you say your combo was because the LSD was MAO-inhibited, or because the two drugs were working their effects together (what beenhead said in other words). ?

I have read too many things saying that inhiniting MAO shouldn't increase LSD EFFECTS.
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I get hardly any noticable effects from maoi's by them selves.
 
The point I was making in that other thread is that MAOIs might "potentiate" LSD in the sense that taking, say, 2C-D with LSD would "potentiate" LSD. The "potentiation" is not due to MAO inhibition because LSD is not subject to metabolism by MAO.

Besides that, the administration of a MAOI with LSD can probably trigger a massive release of placebo. After all, those who experienced the power of MAOIs in potentiating Psilocin or other tryptamines or phenethylamines would expect the same from MAOI + LSD.

I'm pretty sure that FnB can back me up here.
 
I would love to hear a mechanism for the break down of tertiary amines with MAO.

Your first sentence I completely agree with, its not potentiation inthe classic sense, rather an additive effect between two drugs.
 
because LSD is not subject to metabolism by MAO
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Thats exactly my point. So MAOI'S and LSD actually only serve to lower the risk threshold of these drugs, as your basically switching of an enzyme system that has nothing to do with LSD metabolism, but everything to do with keeping other things from your brain.... in effect, LSD and MAOI's is a greater danger then just either, and basically (except for the organic compounds it seems) and therefore there is no reason at all to use LSD in such a manner. Oops that was a questio.... ?
 
^ Exactly.

It just isn't woth the risks involved with taking MAOIs.

And whats wrong with good old LSD anyways? Suddenly its not good enough on its own? ;)
 
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