LSD and Grapefruit Juice

[Zalo]

Hey BlueLight,

I'm wondering if LSD gets metabolized by the enzyme CYP3A4 so I figured asking if LSD gets potentiated by grapefruit juice is an easier way to get the question answered.

I gave this question a search on google and couldn't find anything recent, or anything without mixed answers. I'm hoping there's more information on this now.

Thank you.

 

[sekio]

LSD is probably metabolised by some combination of CYP enzymes, but we don't know for sure.

 

[Brendles]

What's a CYP enzyme?

 

[sekio]

They are common metabolic enzymes in the liver, the CYtochrome P450.

The cytochrome P450 superfamily of monooxygenases (officially abbreviated as CYP) is a large and diverse group of enzymes that catalyze the oxidation of organic substances. The substrates of CYP enzymes include metabolic intermediates such as lipids and steroidal hormones, as well as xenobiotic substances such as drugs and other toxic chemicals. CYPs are the major enzymes involved in drug metabolism and bioactivation, accounting for about 75% of the total number of different metabolic reactions