Again, referring to receptors and inhibitors that are pertinent tolerance and effect based on substance is too technical for reality. Just because some are 5HT2 agonists doesn't mean a noticeable tolerance, in which a dosage increase is required, will be created. As I said, that would take habitual abuse of the same substance of substances in the same molecular classification over a period of time without breaks. Which is very possible, but it isn't going to happen when talking about cross tolerance from a natural tryptamine (LSD), to a non-cross tolerance phenethylamine (AMT), to a limited cross-tolerance phenethylamine (2C-I). This is also backed by the period of time he had between trips and the fact that he would have to have taken the listed three, everyday, for weeks before he would have to take an extra hit of LSD or increase his AMT or 2C-I dosage by 5mg.
Perhaps if he took 2C-E everyday for a week and then began to take 2C-I for a week, there would be a noticeable cross tolerance. And perhaps his first dose of 2C-I may be 5mg higher than what would have been needed if he hadn't taken 2C-E everyday for a week. Or perhaps, if his usual requirement for a decent trip on psilocybin is 3gs of mushrooms and he had been taking LSD everyday for a week before taking mushrooms again, then a noticeable difference will appear and an increase in the dosage of mushrooms will be required.
I also realize mescaline is a phenethylamine but it is a naturally occurring phenethylamine verses a chemically synthesized phenethylamine. The molecular compound is closer to being classified as a tryptamine as are it's effects.
I was simply breaking down that the technicality and mentioning of receptors and inhibitors is minute when considering the fact that not all of them cross with each other, and that it would take extremely dangerous measures of substance abuse, over a gaping period of time, in order to create the cross tolerance he speaks of. I have taken LSD repetitively for a week and a half and noticed extremely small tolerance increases. In fact, none appeared until after the first week. However, LSD is known to effect ones' tolerance more than most other tryptamines and phenethylamines. I've always felt this way and have never experienced any other substance that created a tolerance so quickly, of course a week and a half is still slow. And that includes binging on AMT, DMT, 2Cs, and DOCs for weeks at a time.
