safe?
no. sounds like youre just trying to get "fucked up." thats not what psychedelics are for. stick to beer and coke and cheap shit like that, if all youre trying to do is be not-sober.
dramamine is highly toxic on its own. i cant imagine mixing it with DXM, let alone throwing LSA on top of that. may as well just pop a few xanax and call it a night (that was sarcasm).
take the LSA alone. Maaaaaybe take a tiny bit of DXM, but i wouldnt reccomend it. just sit in a quiet room, with some smooth, bassy music, and breathe slowly and deep. your breath will take you deeper into the experience than a combination of other random OTC drugs will.