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  • N&PD Moderators: Skorpio | someguyontheinternet

Low-Dose LSD as a Dopamine Agonist for Parkinson's?

i guess im asking: does 5-ht2a get downregulated faster than other types of receptors? if you did take a small dose of lsd on a daily basis, could you eventually knock the 2a receptors down enough to start noticing effects at other receptors? im guessing that they aren't all downregulated at the same rates.

for example, it seems to take for ever to get tolerance at cannabinoid receptors, but mu go down fast.
 
the 5-hT2a is the receptors that is simulted the most, there fore unless ou want a 5-TH2a downeagulatio and desinsetisation...avoid using it the day after cuz your playing with fire.
And what about the Mu thing u mentined above?

Anyway daily LSD use sound fun but i'd be worried about side effects it coud produce.

I suggest you read LSD on wikipedia extensively,
 
/navarone/ said:
the 5-hT2a is the receptors that is simulted the most, there fore unless ou want a 5-TH2a downeagulatio and desinsetisation...avoid using it the day after cuz your playing with fire.
And what about the Mu thing u mentined above?

Anyway daily LSD use sound fun but i'd be worried about side effects it coud produce.

I suggest you read LSD on wikipedia extensively,
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i have read that article.

i didn't mean to imply that i would take it every day. i was just trying to make a point. it seems like after a while the 5ht2a effects would diminish, and if the dopaminergic action of lsd is *less prone to tolerance* then lsd might have useful effects as a dopamine agonist.

i do agree that l-dopa is better though, because i think precursors tend to be "softer" since they are more regulated by biochemical pathways. the body is able to use it where there is a deficiency.
 
L-Dopa (the prodrugs of dopamine) is a parkinson medication, unlike 5HTP (which is used when its needed by the body and therefore safe) it will raise the dopaine level throght your body rapidly. L-DOPA comes witha cathecol inihibitor like Carbidopa to a sure tht the substane isnt browkn wn before it reaches the brain.
I would be carefull using L-DOPA for reacreational purpouses.
My go woud be on Tyrosine/phenylalanine (that needs many more enzymathic pathwaysbefore becoming dopamine and its a good substance if you dont want 'drop offs' of dopamine during and after the trip.

Trukey, chicken and good cheese are a source of tyrosine,pehenylalanine and 5-HTP!
 
for example, it seems to take for ever to get tolerance at cannabinoid receptors, but mu go down fast.
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Weirdest one is )probably) the tolerance ketamine (& probably other dissociatives) produce - either phenominally long lasting or perminant (although I belive tolerance to the psychological aspect of ketamine intoxication is prob responsible for anything seemingly perm)


Yeah, it seems that LSD can be pretty dangerous in overdose
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Yeah but that's apparently 3200x the usual effective dose (& IV at that)
 
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alexson said:
I guess what I meant to say was I don't prefer dopamine agonist's because they are more potent, but because the effects are nicer. That is if I had to take them, but I don't.
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Except that what you're saying is completely wrong. L-dopa is better tolerated by patients and is more effective. You're either illiterate or purposely dense. Read the studies comparing the two. There's a really good reason that L-dopa is more widely used.

L-dopa sometimes actually causes euphoria and a nice stimulation. Not often, and it can easily turn to hyperkinesia, but dopamine agonists generally cause horrible nausea, aren't as effective and patients don't like them.
 
I have a question. I am 38 years old and have been living with Parkinson's Disease for 8 years. I took LSD in my early twentys but stopped becasue it did not give me the effects that my friends where getting. Could this have something to do with the PD. I have taken up to 5 widow panes at once and never hallucinated. Could this be due to the PD?
 
LSD is not researched to any great extent due to laws... it was a hot subject up until the 70s but as you can probably imagine research with the substance ceased following its regulation as Schedule I. In recent years, some research has been conducted in Switzerland although I believe that is more towards psychotherapy (which I believe is an extremely relevant field of interest for the drug).

I am under the impression there has been little interest in terms of research on Parkinson's sufferers with LSD. However, there is always potential.
 
There is currently LSD studies with PTSD and Anxiety due to terminal illness.

As souls said these are psychotherapy treatments which are already controversial enough with out the addition of LSD!

However any research in the field is good at opening the doors to more studies! I am very happy that the 30ish year lack of studies on LSD has been broken! We are in a new era for psychedelic research!
 
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