Benzos Lorazepam

[Quickfixgrrl]

Super naive question, but I'm new to Ativan so.....
Can you snort Lorazepam?
Are the effects different?

 

[Michael_25]

I've heard anecdotal evidence of people snorting Xanax and Ativan, saying it comes on quicker and stronger ... but I suggest just popping the pills. Lorazepam does come on quite quickly via traditional administration.

 

[starshopping_59]

Don't snort

 

[Jekyl Anhydride]

Lorazepam, among most all other benzodiazepines, has a high Bioavailability by consuming orally.

To snort it is a waste and an inconvenience. The massive amount of binders & excipients, easily topping 99.xx% will allow nearly none of it to come into contact with nasal mucosa.

The amount lost from crushing, trying to snort, binding with snot, is all lost, The only thing that would absorb is any that made it to the drip stage.

 

[Quickfixgrrl]

Okie dokie ? No snorting.
Thanks all!

 

[mal3volent]

Put them under your tongue or just swallow

 

[andyturbo]

Exactly as Jekyl said! Its a huge waste not to mention like 90% of the pill will be binder. Really not good for your nose!

 

[Quickfixgrrl]

Put them under your tongue or just swallow

This is exactly how I've been taking them.. either under my tongue or just chewing them up.. there's something about the crunch I just love!

 

[Jekyl Anhydride]

Klonopin has a naturally minty taste too. ?

Def no harm in sub lingual-SL. If it doesn't work out it's not like you're going to spit it out.

And this:

Alprazolam kinetics following sublingual and oral administration - PubMed

Thirteen healthy volunteers received 1 mg of alprazolam, as the commercially available oral tablet, by sublingual and oral routes on two occasions in random sequence. Plasma alprazolam concentrations during 48 hours after each dose were measured by electron-capture gas-liquid chromatography. The...

www.ncbi.nlm.nih.gov

Thirteen healthy volunteers received 1 mg of alprazolam, as the commercially available oral tablet, by sublingual and oral routes on two occasions in random sequence. Plasma alprazolam concentrations during 48 hours after each dose were measured by electron-capture gas-liquid chromatography.

The peak plasma concentration after sublingual dosage was higher than after oral administration (17.3 vs. 14.9 ng/ml), and the time of peak concentration following sublingual administration was reached (1.17 vs. 1.73 hours after dose).

However, these differences did not reach statistical significance. The mean total area under the plasma concentration curve for sublingual administration was slightly but not significantly larger than that following oral dosage (203.7 vs. 194.4 hr.ng/ml) and no significant differences between sublingual and oral dosage were found for elimination half-life (11.7 vs. 11.8 hours) or for clearance (86.4 vs. 92.4 ml/min).

Thus, alprazolam absorption following sublingual administration is as rapid as after oral dosage on an empty stomach, and completeness of absorption is comparable. In clinical terms, sublingual and oral dosages of alprazolam are likely to be therapeutically equivalent