Loperamide

So, I decided to try it. Mind over matter (placebo) or unique body chemistry that defies numerous medical journals? I'll let the reader decide.

I dosed approximately 150mg of Loperamide (Imodium in capsule form -- generic).

In a nutshell, you feel nothing for 5-6 hours. Then you notice a slow comeup over 3 hours. Parts of your face, starting with your neck get numb. Then your pupils start to slowly react to dim light, then they go full blown constricted.

At T+10:00 it is unmistakable that there is mu-opioid agonization occuring. It continues for about 24 hours. There are negatives over "normal" opioids: severe grogginess while waking, and of course increased constipation.

One hell of a placebo effect if you ask me. Half of me is glad I got access to a cheap nod, the other half is terrified I got access to a cheap nod -- if you catch my drift. ;)

Naltrexone 50mg tablets kill it (and put you into precipitated withdrawal) in case you experiment a little "too far." I cannot speak as to Naloxone.

IF you choose to use Naltrexone to kill the constipation be warned, it will be 12 hours of absolute hell. Keep suboxone handy -- the bupe will override the Naltrexone as I understand it.
 
The only way in which to gain Agonism from Loperamide is to have the substance directly injected into your brain.It lacks lipid solubility,ergo it cannot defeat the BBB (Blood to the Brain Barrier).It isn't debatable,unless you lack a BBB hahaha.

Don't under estimate the Placebo Effect. If you want some interesting factoids on it there is currently a thread on it in the Australian/Asian Drug Discussion Forum.
 
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