• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Loperamide

Thomas29

Bluelighter
Joined
Oct 25, 2010
Messages
1,505
I read Online somewhere that 2mg Loperamide is equal to 5MG of Oxycodone can anyone here confirm if that is correct or not? I really really need to do a Taper OFF OF 12MG SNORTED HYDROMORPHONE A DAY FOR 1 YEAR AND 7 MONTHS TO BE EXACT with these but do not want to risk making my addiction worse than it already is and or prolong it.
 
Last edited:
that equivalency is not correct. loperamide is a lot less potent than oxycodone.

some people do fine tapering with loperamide, but doses are generally high. if you can stick to a regimen then it will make the withdrawal less painful (if longer-lasting).

what kind of habit are you coming off of?

if its a big habit have you thought about opiate replacement therapy?
 
Well, to be fair Loperamide has about the potency of fentanyl in the brain. The problem is getting it to pass the BBB.
 
Right, as Ketobemidone mentioned, loperamide, if able to cross the BBB would be used in dosages comparable to fentanyl. Unfortunately, it cannot. There is promise using polysorbate 80 nano capsulation that delivers loperamide to the brain
 
It is impossible for the lay-man to get loperamide into your brain. Sorry, it doesn't happen.

For opioid withdrawal, you'll probably need 20-80mg loperamide to start with depending on the size of your habit (work up, not down).
 
I read that and needless to say I am pissed. I am also going through Valerian Root Withdrawal and can not find shit all Info about it. ANYONE WHO SAYS IT IS NOT addictive ALL I gotta say to you is "FUCK YOU!!!" been on it for 4 years now and for that long it is physically addictive.
 
How much valerian are you *taking*? And can you not just titrate off (slowly decrease your dose every week/month until you're not taking it at all)?
 
I read that and needless to say I am pissed. I am also going through Valerian Root Withdrawal and can not find shit all Info about it. ANYONE WHO SAYS IT IS NOT addictive ALL I gotta say to you is "FUCK YOU!!!" been on it for 4 years now and for that long it is physically addictive.


Fuck you too. and you don't have to quote your self silly.
 
pgp cant export it all, it enters (BBB), then pgp exports it out... (loperamide)

it's ok for wd i guess... i recommend staying far away from it. if it's valerian root wd, use fresh ground kava root emulsified in milk (fucking horrible), gabapentin, or mayb
e a little hard cider... there are others...

i wouldnt use opiates for valerian wd, sorry bro. it might help but id rather take an antihistamine or some local cider... likely the latter...
 
pgp cant export it all, it enters (BBB), then pgp exports it out... (loperamide)

it's ok for wd i guess... i recommend staying far away from it. if it's valerian root wd, use fresh ground kava root emulsified in milk (fucking horrible), gabapentin, or mayb
e a little hard cider... there are others...

i wouldnt use opiates for valerian wd, sorry bro. it might help but id rather take an antihistamine or some local cider... likely the latter...

Wtf? I just said I am withdrawing from Valerian at the same time 200-400mg a day for 4 years. I tried tapering off it by using 50mg less a day over a week not sure how much slower taper I should do?
 
What I really need to know is how much Immodium is equal to snorted Hydro like should I just keep popping pills till I feeel fine and than wean from there?
 
Yupppp, that seems safe and pretty much the HR message of this forum.

P.S.
Opiates for val root - killing fly with a tank.
 
Imo, if you're not aleady addicted to opiates, I'd stay the fuck away from them for something comparatively mild as Valerian WD should be. What are you using the Valerian for, and have you tried any other herbal or supplemental remedies, like chamomile or melatonin?

Regarding your loperamide dosage question the previos BLers nailed it, start low, maybe 20mg, but remember that depending on circumstances the full effect may only set in after three or four hours, but will also last a whole.day, so redose slowly until you feel comfortable, then reduce your daily dose from there. I find tapering like this excellent for opiate WDs, but do yourself a favour and Don't trade a Valerian habit for junk addiction, that would be a very bad choice indeed.

On a side note, I reckon a minute amount of lope does cross the BBB if large doses are taken, otherwise it wouldn't eliminate WDs as completely, opiate naive people wouldn't catch a dirty high at 100mg and cause addiction and withdrawals just like any other opiate, if taken in high doses for a long time.

But of course, we'd need to know the reason(s) for taking the Valerian to give better advice. There really may be herbs you've probably never even heard of before which work very well for different conditions.
 
Okay I edited the OP sooo it should not be as confusing sorry everyone. ** facepalms** I am very very Addicted to Opioids/Opiates and I just posted that I am ALSO Addicted to Valerian but I guess that just fucked up my OP lol.
 
2 mg loperamide is definitely NOT equal to 5mg oxycodone. You can't even compare them because they work so differently.

Loperamide DOES cross the blood brain barrier - it is certainly not "impossible for the layman to get loperamide into your brain". The problem is, MOST of the loperamide is rapidly REMOVED from your brain, giving it very little CNS effect unless taken in huge doses or with a p-glycoprotein inhibitor (p-glycoprotein is what removes loperamide from the brain). This also varies from person to person though. Lope primarily affects the opioid receptors in the peripheral nervous system, which is why it is good for things like diarrhea. It can help with the symptoms of opioid withdrawal, especially PNS/body related symptoms.

Stop snorting the hydromorphone, taper your hydromorphone as low as you can, then start with a low dose of loperamide and gradually increase it, then stabilize, then gradually decrease it. There are probably a bunch of other threads on using loperamide for opioid withdrawal if you use the search function.

As for the valerian:
How much valerian do you currently take? Did you think the taper wasn't working and so went back up to 400mg? You could try getting off the hydromorphone first and then try to taper off the valerian after that. That might be easier to do them one at a time, and that is what I would personally do. Not a lot is known about valerian dependence because it is so rare. There is a theory that valerian might possibly be a weak GABA-ergic, (and some well-known dependence-causing drugs are GABA-ergic, like benzos). What withdrawal symptoms do you get from it? And how do you know which ones are caused by the valerian and which are caused by the hydromorphone?
 
I have had to Withdraw from Lorazepam and Clonazepam before and upon quitting Valerian I get very similar symptoms although not nearly as strong obviously and I know it is not Hydromorphone withdrawal because I was high as fuck on it trying to quit. I think I will try quitting the Hydromorphone without the help of Immodium and if shit gets too intense (No pun intended lol) I will take some Immodium 4mg at a time until I feel normal I think that is a good dose to increase by I got no idea it is the Maximum dose at a time on the Package than I will try to Taper.
 
Last edited:
I thought loperamide passed in small amounts when taken after a PGP inhibitor? H2 antagonists such as cimetidine and proton pump inhibitors like omeprazole were mentioned. Quinine, also. From my experience and that of my boyfriend, the cimetidine and large doses of lope were effective. He enjoyed it somewhat, while I was relieved from withdraws but felt very uneasy and suffered faintness. The faintness may have been unrelated, as my BP runs low, but it's only been that bad while taking lope.

I, personally, recommend gabapentin, pregabalin, or baclofen for withdraws if you can't taper. You'll suffer, yes, but it won't be as bad.

Will post more if I've been helpful later, using onscreen keyboard right now.
 
Top