Loperamide peripheral action.

[StueySmit]

Having seen lots of conflicting information regarding Loperamide use, be it as a withdrawal tool for opiate/oid addiction among others, or as a potentiator, I deemed I would make a short post about it.

In layman's terms it is simply this, no need for constant BBB (blood brain barrier) confusion. Does it pass in small quantities does it not.

As a peripheral opiate agonist this means when you feel the effects of course your brain not your body is telling you how you feel. All receptors outside the CNS still have to send messages to the brain. As an example I use Tramadol (almost no body high at all) but plenty CNS action, combined with loperamide makes an actual opiate full on feeling.

Amen.

 

[Kilfer]

In layman's terms it is simply this, no need for constant BBB (blood brain barrier) confusion. Does it pass in small quantities does it not.

It does not. Which is dang frustrating for a chemical that is so closely related to meperidine aka Demerol.

As a peripheral opiate agonist this means when you feel the effects of course your brain not your body is telling you how you feel. All receptors outside the CNS still have to send messages to the brain. As an example I use Tramadol (almost no body high at all) but plenty CNS action, combined with loperamide makes an actual opiate full on feeling.

Would be nice if it were that simple but peripheral action does not contribute to opiate high so any "combo" with Tramadol will likely result in same ol' Tramadol high only with more constipation. Also remember that Tramadol is an atypical opioid while loperamide in spite of its lack of CNS activity, is a typical opioid otherwise.

 

[neurotic]

definitely no CNS activity from loperamide. i take this stuff since forever for diarhea (in fact just took 6mgs like 10mins ago) and never got high on it.

also peripheral opioid action isn't whats responsible for 'body high' - i believe -. it's only responsible for constipation