Loperamide - Mildly Experienced - It works, but who wants it?!

[The Monkey Mantra]

I ate 128 mg (64 pills) of Loperamide on Friday following the viewing of Malfunkshun's thread. My friend Rayce ate 50. It kicked in after about an hour and a half, and consisted of a tummy ache, lots of peripheral opioid symptoms (most notably the frog-in-the-throat thing) and moderate sedation. It progressed into feeling very opiate-like but with only mild analgesia and almost no euphoria. I was *very* calm and relaxed, but I was not feeling "good". In fact, I wanted the stuff to go away! Yeah, it's opiate like. But not in any of the good ways, y'dig? It's like all the side effects with none of the clean, pure pleasure. I woke up in the middle of the night, puked, and went back to sleep. Spent the next day half-alive but in good spirits.

I believe in loperamide's psychoactivity. I also, from personal experience, have found it to be an excellent aid in opiate withdrawal. I used it for that purpose after leaving the hospital after two weeks of heavy dilaudid use following surgery. A lot of that withdrawal was avoided by place conditioning, but the lingering annoyances of it were VERY effectively dispatched by loperamide.

I also believe, from this experience and the couple times before I ate 40 or so pills for shits and giggles, that this stuff totally sucks and is a major waste of time for ANYONE, given the nasty side-effects like not shitting for four days and puking and having a horrible dry throat and looking and sounding like a junkie. *clears throat*

So, y'know, Malfunkshun, I believe you're right. It's no placebo. But I question whether this stuff has any sort of reasonable euphoric potential. I feel better from a cup of maté than I ever would off this noise.

 

[Jamshyd]

See, I honestly don't know why people are still "debating" this. It has been posted a long time ago in more than one, more... advanced, forums (other than BL, as well as in BL's OD and ADD forums) that Loperamide does have activity (esp. when taken with PGP inhibitors) but that this activity is undesirable at best, possibly toxic at worst.

I mean, to put things in perspective, you've just ODed on an anti-diarrhoeal .

You know how much I love you TMM, but had you asked me about this before you went on and did it, I would have smacked you on the head .

 

[stirfry]

sounds kinda like propoxyphene.

 

[malfunkshun]

I mean, to put things in perspective, you've just ODed on an anti-diarrhoeal .

all opiates/opioids are anti-diarheal.

anyway, to the OP:

do you have any kind of opiate tolerance at all? I've gotten the same kinds of feelings from loperamide when I just take too much. a yucky feeling like you described. was it hard for you to focus your vision? also, it took several tries before it really worked for me... kind of like morphine, i didn't get high on that until after a week or two of constant use. i just got that wobbly leg weird stomach unpleasant feeling with zero euphoria.

I'm not encouraging you to try it again, but maybe you took too much or just aren't used it.