High Dose Loperamide & Organ Damage
Fellow members who take Loperamide for recreational effects, what is most concerning to me is not that you can get high from Immodium if you take a high enough dose.
Rather what is *extremely* worrying is people taking INSANELY HUGE doses of loperamide exceeding 60mg-80mg+ which may cause the opioid effect resulting in analgesia, so if you damage your organs and I am absolutely sure that such high doses cannot possibly be devoid of potentially devastating/irreversible damage to kidneys or liver or heart or bowels or stomach or all of the above! I am willing to bet that loperamide has enough side effects when taken at then prescribed dosage! Can you even imagine what it does in doses 100x that? Remember, just because you cannot feel pain it doesn't mean your body isn't in pain!
To answer the original question, yes it would be sufficient!
A 2-4 day break between opioid use will pretty much guarantee any increase in tolerance, as well as minimalize if not completely eliminate the risk of physical addiction.
Regarding physical addiction the first symptoms to appear are constipation or diarrhea! You will also notice a lack of motivation - feelings of being tired/drained of energy as well as what I can describe best as a loss of interest in normal daily activities. For example music won't be as enjoyable, or if you play an instrument you might feel like you don't play as well or you may not even want to play at all. In short what I am saying is you hobbies will loose their magic and you wont be playing video games or whatever unless you are high. However all this starts with what is a lack of motivation, on the days that you don't have it. You may find yourself counting down the days/hours/minutes until your next dose, or you may dream about using it....if it consumes your mind as such then no matter how many days you took between doses, you should even more days apart!
If it still persists, this psychological torture/cravings, then you have become psychologically addicted (if you aren't already, most opioid users fall in love the 1st time they use, psychologically speaking). Plan and simple! There is nothing you can do unfortunately, as humans we are programmed to like it! The trick is to control these cravings but they are very strong, *almost* uncontrollable especially in times of stress, depending how you handle stress.