Loperamide Insufflation

[Arzi]

Damn man, I was just curious.

Christ, forgive me for wondering man, not like I'm trying to ruin your day.

It was one of those "Wikipedia said it so it must be true" moments.

Don't worry. You justifying yourself is just as uncalled for as the rampant "chip on the shoulder" attitude which pervades this forum.

 

[malfunkshun]

Don't worry. You justifying yourself is just as uncalled for as the rampant "chip on the shoulder" attitude which pervades this forum.

and you're just adding to it. if his drawing attention to it is uncalled for, so is your itty bitty comment. hypocrite.

yeah i'm contributing also, so what.

 

[Druggist]

otc codeine. yeah fuckin right. not here in the U.S. hell i'd never even fuck with loperamide if codeine was otc.

i'm working in alaska right now, maybe i'll make a trip over to canada and try out this miraculous nurofen

I know... universal health care and OTC codeine, sounds like paradise.

 

[pibil]

2. associating with a p-gp inhibitor (there's a report of the use of Quinine for this purpose, another one with Quercetin, and a few other ones)

I can't help but wonder if the quinine/quercetin is largely misinformation and confusion.

Quinine and quercetin are worthless for this. Quinidine, a strong Rx-only P-gp inhibitor, might have some value. I think people mispell quinidine once, and from then on people get stuck with one of the typo->pattern matches. Both seem to have some action with P-gp, but with the quinine it seems to be weak and the quercetin quite possibly limited to the intestines. I've not gotten any additional BBB crossing taking massive doses of either or both of these available substances with loepramide. I do not have access to quinidine, though.

One other potential option is bergamot oil. Which is probably a bad idea, because it might be toxic in some other ways. But, it is suppoed to contain the same P-gp inhibitor as GF juice, bergamottin. Grapefruit oil contains it as well. The reason I mention them is that in reasonable doses (juice of two fresh squeezed grapefruits, liter of non-concentrate organic store-bought GF juice) I've never had any effect.

Though, it could just be that taking P-gp inhibitors just don't do anything, or at least not in non-insane doses.

pibil

 

[pibil]

Just to let you guys know: it's been another 3 weeks, with no opiate but loperamide and I'm still clean, still WD-free, and still tapering down. I couldn't agree more that for opiate naive people loperamide is pretty much worthless, but for folks with opiate addictions, even large, long term additions, it is heaven.

Codeine would be nice to have available, yeah, but unlike some of the folks here I'm done with getting high. Opiates don't do shit for me anymore except make me sedated, lethargic and to some extent dysphoric. I no longer have the euphoria, energy or socialability, and I haven't for a few years. Maybe quitting for 6 months will bring that back, I don't know. I'm glad to have loperamide, because for maintenence/tapering, it is better than codeine and methadone in many ways. The codeine would be a huge pain in the ass; with my tolerance, even as much as 100mg of hydrocodone did a little bit to relieve WD symptoms, but it wasn't enough to get my high. I can't imagine the immense cost and time it would take to do CWE on bucket fulls of OTC codine/APAP even if it were available were I am. I once had access to some codeine cough syrup, drank the entire bottle (90mg), got NO relief and a few hours later started puking up lots of nasty red. Loperamide is cheaper than codeine and methadone, it's available OTS, on my time, no waiting at a 'done clinic, no worrying about the amount of codeine tablets I'm buying being tracked, etc. While 100mg of hydrocodone might do little more than relieve some WD symptoms for a few hours, 48-96 mg of lopramide has me feeling *normal* for 24 hours. No WDs, bumping into stuff doesn't hurt, I have energy (unlike on other opiates)... In short, it's living life without being permastoned.

Like I said, if you're looking for a new opiate to waste a lot of time and money on getting high off of, loperamide isn't it. Not saying it can't be done, but for fuck's sake: why not get some kratom or codeine? or PT if you're interested in courting a habit? For those of us ready to move on, who have already "been there, done that" it can be a godsend that folks still fucking around won't understand until they are at that point themselves.

 

[pibil]

Even IF loperamide gets through the BBB, it won't get you high. I've read the papers and the SARs show that it's just Sooooo weak. Try lopping of that chlorine with NaBH4 then esterifying the bare -OH group. Good, now you have something about 1/5 the potency of codeine.

Folks, this stuff is OTC for a reason. A LOT of time was spent ensuring that it was NOT abusable.

Where did you get that information? First, let's do a thought experiment. I assume that, from your statements, you're claiming that loperamide is less than 1/5th the potency of codeine, as is, correct? The specific doesn't matter, but if "lopping of that chlorine with NaBH4 then esterifying the bare -OH group" yields something 1/5th the potency of codeine, I assume that you believe loperamide is less than that, - I don't know why you'd talk about modifying loperamide to make it weaker, but just stating my assumptions.

Loperamide easily constipates non-tolerant folks at 2-4mg. I can't imagine getting that kind of enteric opiate receptor agonism at 2-4mg with a substance that is less than 1/5th of the potency as codeine. Do you know anyone who gets constipated from 0.4-0.8mg or less of codeine? Do you know any adults who could detect the 1 mg of codeine doing anything, at all?

The papers you read must be different ones from the ones I have. In studies where loperamide was delivered into the spinal fluid loperamide was more effective than morphine on a mg per mg basis. In studies where they injected loperamide straight into the brain, loperamide was shown to be 50 times as potent as morphine, or about half as potent as fentanyl. Mind you, loperamide has a much longer duration of effect than fentanyl. This is if loperamide goes across the BBB.

If your going to go to all that trouble, you would be much better to spend your time and effort looking at other OTC stuff because there IS stuff out there that can be made fairly good...

...like what? For the many of us who don't have codeine OTC, please do enlighten us as to the OTC stuff out there that can be made fairly good. Inquiring minds want to know!

pibil

 

[ombladon]

WHERE AND IS IT EASY TO GET polysorbate 80 ?

 

['medicine cabinet']

i can only imagine what would happen if the mass medai knew about this thread..

headlines would read: Addicts now turing to anti diaarehal medince to get high

its not something i would be interested in trying. i have taken it before during WD kicks to calm my guts from rumbling. as for recreational value, if it doesn something for some people, thats great. it just doesnt seem worth the constipation and knowing that you are taking pills so you dont shit your pants.

if you want to get high on opiates, get some heroin.

 

[Netyaroze]

In Germany there was a hype about Loperamid. A lot of kids tried it and some of them had a pretty amazing experience. Even in the media they reported about the "new" Heroin substitute from the Pharmacy.

If Loperamid could pass the blood brain barrier it would have a big potency. About twice as high as Fentanyl (about 200). And its related to Piritramide.

They did some research about Loperamid. Maybe something is true about this ? One made a trip report about his Loperamid turn. Only a little percentage of people have recognized a turn one of them almost die.

The theory was that with Chinidin the Enzym (?) for the retransport of Loperamid would be de activated. You have to take 2 days before Chinidine and then a small amount of Loperamid (4mg). They say that it will work with Doxepine and Chinin to. chinin is contained in some sorts of bitter lemon i guess.

Some Kind of dogs dont have the enzym (is that the right word ?) for the retransport of Loperamid and they will die because they arent able to deactivate the Loperamid.

The people say that its a incredible strong euphoria. And nothing is comparable to this. They werent even able to find the right words to discribe this. Some of them even injekted the stuff in combination with Chinidin or something like that. One of them gets Hydromorphone and Oxy cause of pain and he said that he was impressed by the strong Analgetic effect of Loperamide

dont now whether they are lying or not. But i cant imagine that so many people tells that much shit maybe some sort of mass psychosis ?

from the theorie it could work with a booster substance. But no one can predict the effects and its very very dangerous.
I wouldn try it. Its interesting to see someone who would kill themself only to test a new way to get the ultimate high but its nothing for me. If there were some more and exact experiences with Loperamide i would give it a try but noone knows something precise.

 

[pibil]

For those who are curious- chinidin is what the Deutschlanders call quinine. Can't say it's ever worked for me, but it would probably be more practical to try taking quinine pills (anti-malarial) for a few days rather than drinking a few liters of tonic water each day for a few days. As an aside, the loperamide hasn't made me high in ages though my WD symptoms are still well under control, which is fine by me. I took 1.2g of DLPA a bit after my loperamide dose and had a noticable opiate buzz going. DLPA has been proven to potentiate opiod analgesia, and with non-opiate toleranced folks seem to give a bit of a high on its own. I was taking it more so as a dopamine precursor, but was pleasantly surprised to have a 6 hour buzz. Nothing strong, like 10mg hydrocodone was for me when I was opiate naive, though without the itchiness and coldness of nose. Just FYI...

 

[rave23]

yadayadayada

good, long post about how to take lope

yadayadayada

okay, here my first hand experience...
I am off any opiates now for about 3 weeks and my tollerance is low i believe.
After getting headaches about all the discusions here about weather it works or not i walked up to the next pharmacy and got a few things!
2 Days before i switched to orange juice in the morning and grapefruit in the evening completley as a drink. I stopped coffee and soda, just juice (i love orange juice, so i don't care ! ). I used 100% pure orange juice with pulp from minute maid and pressed my own grapefruit juice, since that is - believe it or not - cheaper. I started taking therapeutic doses of Magnesium as directed. Since i am not a girl i don't had problems with Progesterone either 8).
I switched my nutrition to a plan that avoided suggar and caffeine as good as somehow possible.
Now i have to admit that after day 2 i experienced some bad ass diarreha and passing gas, so i kinda looked forward to throw some lope lol.

Okay, at the end of day 2 i took 30 mg lope on an empty stomach (well, it was full of orange juice and grapefruit), and snorted about 10 mg lope. The reason why i say "about" is because i actually don't know. Since 5 tabblets are way to much to snort i extracted them with a CWE. I crushed them up, put them in warm water, shaked the hell out of it, colled it down to 4°C, let it sit at 8 hours at that temperature, filtered it with some lab filter paper and evaporated the water away while not exceeding 45 °C to avoid damaging the lope. I am not sure if that actually worked or not, but i was left with some tiny ammount of white-ish powder that had kind of a green tan to it (coating of the pill was green). It tasted really bitter, and it reminded me about the bitter taste that a cwe with codeine has.
Okay, so i threw the lope, waited 10 minutes and railed the powder. It kind of stung a little, the drip was horribly bitter and made me nauseous,

I felt nothing for the first 30 minutes after railing, and i was kinda dissapointed (well, i expected nothing in the first place lol). However, my diareha was gone! Then really something happened. NOTE: All of the effects may have been a placebo effect. I felt a slight allertness in my chest, and then a real noticeable feeling of heaviness could be noticed in my arms. Somewhat similar to a codeine high. Then i felt "something" rushing to my head. Nothing like euphoria or the feeling that Heroin IV gives you though. I absolutely felt something spreading in my head, i could best describe it like it was numbing my thoughts. I got up to check my pupils, and i noticed i was kinda dizzy and lacking response. My pupils however looked normal. I went back to the couch because i felt kinda heavy and not moving felt really good at this moment. I had a deck of cards and was just playing with that, shuffeling it, looking at cards, trying to guess the next card and all that sort of shit. Suprisingly that was so entertaining in a weird way that i didn't even noticed that 3 hours went by just with lying on the couch playing with a deck of cards. I wasn't even paying attention to them, it was like my thoughts kinda wandered around, feeling all numb, free from any concern. T +5:00 and i certainly felt like i was on opioids! I was feeling warm and numb and comfy. Not a strong feeling, rather subtle, but highly enjoyable. I watched some TV and at T +7:00 i drifted off into sleep feeling all cozy and good.
I woke up 9 hours later feeling normal. Despite some people saying that you "won't shit for a week" i took my next crap 36 hours after ingestion of the lope. It certainly was hard and kinda difficult to pass, but it was possible. I wasn't constipated as badly as i thought i would be.

My result: Not worth the troubble at a dose as low as i used it. It was certainly enjoyable, but 300mgs of codeine with 3 benadryl and a Norflex would just be as good imho (Note i have zero to low tollerance atm). But i certainly felt something (note again: this may be entirely a placebo effect). I may try it again in a bit but take like 2 or 3 times more. i also want to get my hands on some Amitriptyline...

I hope i contributed a bit to this topic wiht sharing my experience. Whoever might be calling "Bullshit" - You can't deny the experinece of other people. I also said it might be entirely placebo.

If you have any questions feel free to ask me and i do my best to answer them as accurate as possible.

cheers,
Rave

 

[pibil]

I will repeat this tommorow, but the loperamide has long ago no longer made me highish. I'm tapering off opiates using it, and have been on it for a couple months and I've not had any other opiates in that time. I've always been very disdainful of claims of grapefruit juice or quinine helping loperamide cross the BBB, but now I'm not so sure. I drank a cup of a brand of organic non-ruby red GF juice before my loperamide dose, and another cup in the 30 minutes after taking it. I am definately high, not recreationally so, but more than I've been on loperamide, ever, even though my dose is tapered down from what I started on for maintenence. I do have some other drugs in my system, but I've never seen this reaction before, and they're in the same doses I take every day and have done so for over a year- 2400mg piracetam and 10mg dextroamphetamine (Rx). Interesting. I'll try this again tommorow and share the info, though I sitll don't think this is recreational in the least bit, but it does make being off the opiates a little easier.

 

[fuzzywuzzy123]

ha I find it funny how a lot of people say you wont shit for a week, first off its out of your system in 24 hours, ive been using loperamide every day for a month in high doses and have never had a problem going to the bathroom, sure your prob not gonna shit with it when its in your system, so just delay the next dose by a few hours and you will be fine.

 

[fuzzywuzzy123]

well for me its day 32 on Lope maintenance, came off cold turkey from a very large and long opiate addiction, this past week has been good, first my emotions started to come back which was very nice because for the last 5 years i havent really had any, instead of crying or losing sleep of something I would just snort an OC and that would be my emotional escape. Also this week my appetite started coming back which is much needed, I lost about 15 pounds this past month and am starting to look sickly.

I started with 100mgs of loperamide the first few days and ive been tapering ever since, im down to 20mgs a day now, taken Orally with 800mgs of tagamet 1 hour before dose of lope which makes it last a full 24 hours, ive stopped at this dose for a little over a week.

2 days ago i skipped a dose to see what would happen and within about 4 hours I could feel the withdrawals coming on (hot cold flashes, sweats, anxiety, restlessness) so I waited another 18 hours to see how bad they would get, they werent bad at all compared to a large OC habit but they were enough to make me very uncomfortable. Tomorrow I will be starting to taper down again, and in a month I should be off, Im curious to see if I will get any W/D symptoms from stopping at 2,4 or 6mgs.

I dont know what experiments with lope havent already been done and reported on BL, Ive tried just about everyone one (except the ones involving hard to get chems and equipment like polysorbate 80 etc.) to try and get it to cross the BBB, and like many others all I could achieve was a little body high, which is pleasant especially when kicking the habit, the effects on the body are to be expected I would guess since there are opiate receptors in a few different places throughout ones body.

 

[ChemicalSmiles]

100 loperamide pills? You must not have shit for a week!

 

[fuzzywuzzy123]

100 loperamide pills? You must not have shit for a week!

100mgs not pills, but that doesnt matter, even if it was 200mgs it wouldnt not back me up for a week, just becuz its marketed as an anti-diarrhea pill people always asume that it would, its half life is 12 hours so it cant back you up for a week. its an opiate that doesnt cross the BBB and since opiates stop you up thats why loperamide is meant to be used in this fashion, once the loperamide is out of your system in about 24 hours you will be able to shit again.

 

[enoughorangejuice?]

^ at that dose does it hurt your tummy?

 

[malfunkshun]

Hey, malfunksun, drop in and update us with the lope maintenance. Hows it going, how much, how often, MOA, enquiring minds want to know since you seem to be the test subject willing to experiment with our theories and ideas of loperamide on yourself. Are you still taking it daily? What's the deal man?

since you asked, ok. here's whats been happening.

when i posted that last little update i think it was about mid june... and yeah, i've been taking loperamide a lot between then and now. my highest dose has still been about 200 mg. at that dose i find it extremely hard to focus, my eyes tend to cross involuntarily, and my head feels foggy... not entirely pleasant. right now i am trying to taper off of it because i am in a zero money situation, i can't even afford any loperamide anymore, and i don't want to withdraw from it. i have been tapering down 10 mg a day for a week or two. i'm down to 25 pills now (50 mg). i took 30 pills yesterday. 35 the day before that. 40 the day before that. and so on... tapering from about 80 pills a day. i haven't had to withdraw yet, except for one day when i was flat broke and just had no choice (i sold a few books so i could get some loperamide and kill the wd's) and i think going through those wd's actually helped the tapering process when i started it again. so, by tapering down 10 mg a day, i've been able to pretty much keep the wd's under control. we'll see what happens when i actually get down to that 10 mg day (about 4 days from now... yikes).

anyway, i have found that sometimes, not always, but mainly when i've been off of it for a few weeks (maintaining on other stuff) that when i take about 100 mg with no tolerance, i get a really good high. still not as good as say... poppy pods or whatnot, but I definitely get a really great mood and i'd swear that i am experiencing euphoria. not the same as regular opiates mind you, but still there. i would say that loperamide, with a junkie like me, when i am switching from some other opiate directly to it, is DEFINITELY has recreational value.

one more thing. loperamide has never upset my stomach... UNLESS i take the coated pills, the shiny green round ones. the easy to swallow ones. those will cramp you up like a mother. NEVER take those for loperamide maintenance or to get high or anything... take them ONLY legitimately at the recommended dose.

 

[melange]

lmao


withdrawing from loperamide


that is the most ludicrous thing i have ever heard

 

[malfunkshun]

lmao


withdrawing from loperamide


that is the most ludicrous thing i have ever heard

well, ludicrous or not, loperamide is an opioid and you can withdraw if you take a lot for extended periods and quit cold turkey. you don't have to worry about though, just stick to light beers and no-doz and you'll be fine.