Opioids Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope

[strigoi]

It's be almost 48 hours since ingestion. I still felt strange yesterday and today I am bloated, no sign of a BM in sight, however I am a daily opiate user so I am not concerned yet.

I feel I should reiterate what others have said , loperamide does work, but should only be used to help WD's. I can't recommend going more than 48mg's either, it seems that past that point the only thing that gains in strength is the side effects.

The recreational benefit for me was null, taken the side effects into consideration as well and the experience wasn't worth it.

 

[Jabberwocky]

May I suggest fiber? I would expect that my fiber rich (lots of leafy green veggies; psyllium/Metamucil in a stretch) diet had a lot to do in terms of not suffering any extraordinary bowls issues. Then again, back in the day when I started (ab)using opioids I certainly had been known to go two+ days without a shit. Certainly can be frustrating, nonetheless.

Yea, if one doesn't really like tramadol's effect, especially a long lingering slightly less intense tramadol effect (again that linger and linger), and hasn't been using a lot of opioids regularly atm, extraordinarily high doses of lope are probably not the best idea.

 

[Treefa]

one time i took like 28 2mg pills...
i felt it, like some VERY weak Darvocet haaha..wouldnt even say weak tramadol maybe some tramadol that someone left sitting out in the sun for a few years or some shit

But it made my muscles feel wierd, like i had been lifting weights or something, and i didnt have any weed to take away that odd sensation....

Personally, i think it's just a waste of time and an unnescearry health risk unless you are actually in withdrawl

I did'nt shit for 3 days, and when i did it was rock hard..well rocks if you will, more constipating than any other opi's

 

[Jabberwocky]

As one of my earlier posts on lope states, the potential benefits of using extremely high doses (which is what you need to do to get a legit high from it) do not outweigh the potential harms of said dose for the vast majority of people.

However, there are those few moments, for a few people such as myself, when it has been overly beneficial to take a shit load of the drug, and consequently feel its true potential (in the high department at least).

Using the drug recreationally vs using it to combat w/d are two completely different things. And most would be strongly advised to stick to using it for only the latter reason... That is, assuming the potential harm out weigh the potential benefit...

 

[stbizzle]

wow this thread is still around..
the molecule weight is 500+ to big to cross BBB
someone has to have a simple way to remove the HCL salt
hell someone try this, add lope, h2o, and 91%iso to solution
we know lope is like 90% soluble in alcohol,

either a the lope will come out with the alcohol vapor providing you keep it under waters boiling point
and the salt stays in the water, if i'm not mistaken HCL is polar?

then if not your gonna have to rig up a still like the cook moonshine so HOPEFULLY the hcl escapes with the h2o vapor
and you lope vapor once collected could be evaporated into something useful?

has this been tried yet? 8)8?

 

[tricomb]

I haven't heard of anyone doing it. 91% iso is 9% water, so factor that in to how much water you add, and if you try this please post the results.

You'd need the right labware though, true pyrex. Also, factor in the temperature at which loperamide degrades.

 

[stbizzle]

I've been thinking about this for 3days now, fuck trying to change it's structure perhaps we just need another way to carry it across the BBB
Has anyone done something simple like get the gels and add it to Polyethylene glycol say peg300 as a carrier, unless you want to do the whole crush the tabs with alcohol extraction the get make a polyethylene solution, unless we know if it works or not I would say it wouldn't be worth the extra time.
Only problem is with it so closely related to fent if this is a simple way to get it to cross what would be a starting dose that would not be fatal...

also i've seen people chugging gallons of tonic water. I've tasted that shit and it's terrible, hell eating gaba supps and glucose tabs from store sounds like a better idea to me and taste better but for real.

anyone that has knowledge think we could use peg as a carrier?

 

[stbizzle]

I haven't heard of anyone doing it. 91% iso is 9% water, so factor that in to how much water you add, and if you try this please post the results.

You'd need the right labware though, true pyrex. Also, factor in the temperature at which loperamide degrades.

iso evps much quicker than water it's just whats the point is your pretty much doing an iso extraction with heat

 

[stbizzle]

Going to attempt to make 10mg lope with zinc oxide using polyethylene glycol as the carrier if I can get it to hold in solution. If this does not work I may try another 10mg zinc oxide solution via a transdermal delivery system. There has to be loop here the Japanese company that developed lope was seeking a powerful pain agent just never could delivery. Just have to be carefully change the structure cause you could create something that could cause life long problems even death. Though if reports are true and cats were consuming 96mg at a time fear not i guess?

It's just the molecular weight is so high that's the main problem, maybe someone could just not eat any carbs at all for a day until they were about hypo. Eat about 20mg lops and chew up several glucose tab. Your body would want to the carbs so bad it just lets it all though?

I'm a college drop out don't have a real deep back ground in chemistry

 

[tramerall]

Greetings Everyone. I have been a lurker here for a while and thought this would be a good time to chime in on the subject of loperamide. A little info about me, in 1994 I was diagnosed with acute Crohns Disease, which some of you might know is a disease that attacks the gastro system. For me particularly the large bowel. I have roughly 1 foot of my large bowel left, so as you can imagine, I am prescribed generic loperamide. Now, I never knew it was an opiate till I discovered this site, and various other sites. I am also prescribed tramadol, which is my drug of choice. I eat tramadol like it was candy cause I have been prescribed it since 1994 for restless leg syndrome. I have such a high tolerance to it anymore, I can take an entire bottle of 90 in less than a week. I've never had a seizure (knocks on wood).

I would go through some serious withdrawl from the trams, and as some might know, the wd's from trams sucks. Then recently, I was reading on how loperamide can help with the wd's from trams and other opiates like vicodin. So I experimented, and I can honesly say, it works. What I do is about an hour before taking loperamide, I take 3 or 4 Tagamet and if I have them, 1 or 2 Omeprazole. Now the past couple of days I have been experimenting. For example, tonight, i took my usual tagamets and 1 om's, and an hour later took 140mg's of loperamide. I am prescribed 360 2mg loperamide pills a month to take as needed.

See, most Crohns patients have constant diahrrea, I never have normal stools, normal stools for me is the runs. So taking that much lope will not stuff me up. Before I took the lope, I looked in the mirror to see how big my pupils are, and noted how I feel. I was tired, and my pupils were normal size. About 2 hours after taking the 140mg's of lope, I felt like I had taken my tramadol, had that slight speedy feeling, felt as if I was in a better mood. I looked in the mirror, and my pupils were tiny. As if I took a ton of percocets. I don't know if I would say I was "high", I just felt better, somewhat energized.
So I would have to agree with the others who feel as if loperamide can save your ass if you run out of your d.o.c.'s. Oh, I also seem to think the loperamide I get from wally world seem to have a better effect on me than my prescribed ones. My prescribed ones are brown capsules with loperamide powder inside. *shrugs*

 

[Wolfmans_BrothEr]

has anyone successfully quit opiates using loperamide? i mean not maintaining on lope but using it to soften the blow of wd. ive done alot of searching and i cant seem to find consistent or reliable answers

i have a moderate opiate habit, 30-90mg oxy/day or 4-6 bags of #4 diesel/day

i was clean all summer and relapsed the first week of sept. mainly ive been taking kratom 3x/day every day but ill take oxy or h once a week, sometimes ill dose 2 or 3 days in a row

it doesnt sound like that bad a habit but i used to be a much heavier opiate user and my brain has been trained to get addicted quickly and thrown into wd much faster and more severe, or so thats what ive been told. im not doubting it since thats def how it feels

i need to get through this wd fast, like within the next 11 days. how possible is it to use lope to aid in wd without prolonging it? ive been considering taking 10-12mg/day for the next few days (no more than 3) starting tonight. considering my history what can i expect once i stop the lope?

 

[SaosinEngaged]

^^^ Yes, people do it all the time.

I have to say, if anyone actually gets dangerously close to making Lope cross the BBB in higher quantities, BE FUCKING CAREFUL. Miniscule amounts of it cross the BBB, so when taken in higher doses, you do get some effects. But we're talking miniscule, almost insignificant amounts. If you do something to chemically alter the Lope to cross the BBB, you may end up with a substance that, if by only ingesting one 2mg pill, you're taking something on the order of Fentanyl's strength and almost guaranteeing putting yourself in a body bag.

IMO, tread carefully. It would be great if someone could find a way to extract more recreational potential out of Lope, but it would be terrible if someone died in the process.

This reminds me of the topic of trying to somehow extract or create more norbuprenorphine from bupe. It sounds awesome in theory, but would likely be fatal if someone were to succeed and weren't exceedingly cautious.

 

[Wolfmans_BrothEr]

ok so i dosed 12mg 16 hours ago and i woke up feeling fine. slept decent, not sweating my ass off, somewhat hungry, increased mood, no rls but ill get chills occasionally. basically i feel content.

could this be my wd subsiding or would u guys think the lope is still affecting me? half life is 9-14hrs but ive heard people say take it no more than every 3 days which makes me think the lope could still be working

keep in mind this is coming off a moderate opiate habit, nothing too severe

 

[SaosinEngaged]

I've felt the WD reducing effects of Lope for a solid 24 hrs in the past. It's definitely very long acting. Keep in mind, the lower your tolerance, the better it works. If you have a monster habit, it can only do so much. But I've read accounts of people with mild to moderate habits that felt almost normal after doses that aren't even ridiculously high. Lope is an underused but somewhat miraculous (given its OTC status and price) WD aid that, I think, people still don't utilize it to its full potential (away from BL) because, I mean, it's "diarrhea medicine." When you tell these people it's an opiate, they usually go .

Now, if you combine Kratom and Loperamide, get ready to have a "too good to be true" time WDing from a (relatively) moderate to small habit. Kratom will definitely fill in the blanks left by Lope alone.

 

[tentram]

i've a reasonably extensive habit (nothing too huge, just many years using and abusing) and i'd agree around 8-10mg lope holds me for 24 hours or so. that's a habit where i'm IVing a few hundred mg morphine per day with high dose codeine as well.

you only want to use it temporarily for the shits otherwise you can build dependency to the lope itself.

 

[Cane2theLeft]

ok so i dosed 12mg 16 hours ago and i woke up feeling fine. slept decent, not sweating my ass off, somewhat hungry, increased mood, no rls but ill get chills occasionally. basically i feel content.

could this be my wd subsiding or would u guys think the lope is still affecting me? half life is 9-14hrs but ive heard people say take it no more than every 3 days which makes me think the lope could still be working

keep in mind this is coming off a moderate opiate habit, nothing too severe

The therapeutic effects of loperamide will last around 24 hours. When I was using it for withdrawal, I found that I could dose it every 24 hours and shortly before the next dose took effect, was able to have a normal bowel movement but it would stop most of the withdrawal symptoms.

It's all about finding the right dose and striking the right balance with how frequently you are taking it. You don't want to take so much that it blocks you up for several days but enough that you are not feeling terribly sick. At this point, the loperamide is probably still holding you. You're best bet is to keep taking it every 24-30 hours (or longer if you can) and reduce the dose by 1-2mg each time until you are done. Tapering gradually like that will reduce the largest amount of the withdrawal.

If you use the same dose of loperamide for a few days then just stop, you'll probably still have a lot of withdrawal and it would have been largely just prolonging the inevitable. You want to gradually taper off of it to get yourself off the opioids as gradually as you can.

The MOST IMPORTANT aspect is having a plan to deal with things once you are opioid-free or you will be craving them very soon and likely relapse in no time. You need to have a way to deal with stress and cope with cravings and so forth if you want to stay off them for good.

 

[Kratom bomb]

I am sick of people bashing this. The first time I did it, it was so powerful it made me scared for a little while. It works. I have a feeling that most of the people who bash this have only read the forums and not tried it. I am on 72 mg= 36 pills right now + cimetidine + quinine. The BBB issue is easy to bypass, it works without the inhibitors too. It has never been a placebo effect. The feeling is not identical to a regular opiate and has elements of it's own, but it is a genuine, long-lasting high. I love it. It makes me slightly itchy, incredibly drowsy, slightly euphoric, causes pin-point pupils, reddened eyes, and a tingling sensation. It works every single time, it is very repeatable. The only bad side effects I get are some constipation = to other opiates + plus distinctly swollen shut nostrils(note:I do not snort it)not accompanied by mucus. The plugged nose happens every time without failure, does anyone know why this happens? I have extensive drug experience and I know when shit does not work. This DOES WORK.

 

[Wolfmans_BrothEr]

The therapeutic effects of loperamide will last around 24 hours. When I was using it for withdrawal, I found that I could dose it every 24 hours and shortly before the next dose took effect, was able to have a normal bowel movement but it would stop most of the withdrawal symptoms.

It's all about finding the right dose and striking the right balance with how frequently you are taking it. You don't want to take so much that it blocks you up for several days but enough that you are not feeling terribly sick. At this point, the loperamide is probably still holding you. You're best bet is to keep taking it every 24-30 hours (or longer if you can) and reduce the dose by 1-2mg each time until you are done. Tapering gradually like that will reduce the largest amount of the withdrawal.

If you use the same dose of loperamide for a few days then just stop, you'll probably still have a lot of withdrawal and it would have been largely just prolonging the inevitable. You want to gradually taper off of it to get yourself off the opioids as gradually as you can.

The MOST IMPORTANT aspect is having a plan to deal with things once you are opioid-free or you will be craving them very soon and likely relapse in no time. You need to have a way to deal with stress and cope with cravings and so forth if you want to stay off them for good.

cane thanks for the response. i took 12mg 28hrs ago and im still feeling ok. i took some kava an hr or 2 ago and i feel like that mightve helped. but i slept better last night than i have all the other days taking lope leading up to this one. so im taking that as a good sign

occasionally ill feel like im starting to wd but i feel like its mainly mental since im just sitting here bored as fuck. if anything ill take 6mg but im trying to hold off as long as possible

ill add that when i first started this detox and when ive withdrawn in the past from much heavier use, id have to take 10-12mg every few hrs to get some relief, and even then i didnt feel as good as i do now. so i feel like it may be working? i dont wanna throw myself into a false sense of security tho...

id like others opinions on my progress tho. am i basically in the clear or is the lope making me think i am? would taking 6mg 30hrs after my last dose do anything to seriously delay my detox? also ive never been an alcoholic but the past few nights ive been having the desire to drink if that means anything...

 

[i are spectre]

im trying to reduce to. i took 20mg instead of 24mg. im sweating but not so bad. headache but its from all the other OTC meds.

 

[pasha]

After discovering that loperimide can rid you of withdrawal and get you high I decided to try it. I read some claims in this thread and others that loperimide doesn't constipate you more than other opioids. WRONG. Here is a study claiming otherwise:

http://www.ncbi.nlm.nih.gov/pubmed/6502516

After getting on loperimide at doses of 100 milligrams a day for several months I woke one night vomitting acid and blood feeling like I had a puncture in my stomach as a tire was punctured. Intense hiccups, bloating and stomach pain. I picked my ass up and rushed the emergency room. I told them I had taken loperimide and they were not convinced, in fact humoured. All it took was one projectile for them to take it seriously. They drew blood, gave me and abdominal/spinal x-ray, and an ultrasound. They found intestinal blockage, megacolon, initial signs of kidney failure, and sepsis. They surgically removed the fecal matter in my intestines, evacuated my colon, gave me lactulose to sooth my intestines and help relieve constipation, put me on two anti-biotics, and a PPI. They kept me for 2 days and released me. I left with a great feeling of happiness thinking "oh well at least I escaped withdrawal." WRONG. The next day it started kicking in, shitting, pissing, and puking at the same time. So I fixed up and squirted up my arm. Nothing. Not a single bit of relief. In the end, all I was left with was a huge tolerance to heroin which I don't know when it will reverse, constipation, diarrhea, vomiting, a fucked up digestive system, and disgusting withdrawal symptoms. It's been two weeks now and I'm still feeling them hard on. Only one drug made me suffer worst withdrawal and that's pregabalin, that's for another time though, for now: Word to the wise, use as intended and don't believe all the bullshit people are willing to convince themselves to justify a dirty, dirty, habit. There's no easy escape. I'm just so disappointed I was fooled yet again.