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  • BDD Moderators: Keif’ Richards

Loperamide as an opiate potentiator

KS78

KS78

Bluelighter
Joined
Apr 9, 2008
Messages
945
I searched the forums but couldn't really get a good answer. Does Loperamide potentiate opiates? I also read that Loperamide decreases the metabolization of some opiates, does this mean that the opiate stays in the system longer? If I wanted to decrease the amount of opiates I consume by half, around what dose do you think that it could be effective?
Thanks.
 
Loperamide is a peripheral opioid agonist and hence doesn't produce much "central" opioid effects - it mostly acts on the gut to slow its activity, rather than a painkiller or euphoriant.

I don't think it is a very strong enzyme inhibitor so it wouldn't produce major changes in how long existing drugs take to be metabolized. I'd say you would be lucky to get a 5-10% potentiation, if that. I very much doubt it would reduce your opioid use by 50%.
 
@sekio is bang on here, I would however add, that it was initially synthesised to be a painkiller, and peripherally is the same potency as Hydromorphone. I have had mood enhancement above 25-30mg but it’s not advised. Essentially, take away any opioids ability to cross the BBB, and it could be marketed as an anti-diarrheal!!
 
When you took that amount, did you combine it with any potentiators like Omeprazole?
 
No @KS78, just the lope on an empty stomach. Please note however, I only do this very occasionally to minimise withdrawal, it’s not really sustainable as a potentiatior.

In a simple sense, it should fill up your peripheral Mu receptors (mainly gut) leaving your DOC free to saturate more brain receptors. Doubt it works that way though!!
 
I want to use it for withdrawal as well; this thread was more curiously related. I have been reading about it for many years but never but this time I probably will.
Before, for many years, intravenous heroin and cocaine was my addiction which I both used in quite high doses. I usually went cold turkey and I stopped with Methadone as well Buprenorphine a few times. My last time was cold turkey which was about 10 years ago.
After about 10 years off heroin, being a cocky junky, I got dependent on opium and dried poppies.
I have to taper down as much as I can then I'm thinking of using Loperamide. I use about 500-600 mg of opium a day so about 60 mg of morphine + many other Alkoloids.
How much and what were you using that 30mg of Loperamide gave you relief? Do you think that 30mg Loperamide is a good dose for me to start with in orderto get through the acute withdrawal? It makes me nervous because of the effects on the heart but I don't have another option.
 
KS78 said:
When you took that amount, did you combine it with any potentiators like Omeprazole?
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Omeprazole potentiates opioids?! GODAMN IT I have a script for that and have been not taking it because I thought it would have the opposite effect. Someone on here told me that the less acidic your stomach was, the less opioid was absorbed (or something like that).
 
KS78 said:
As far as I know, it's just the opposite; a basic environment helps them to be absorbed better.

"It's not an opioid potentiator, it IS an opioid."
I know that.
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That's what I'd thought too. The guy who misinformed me is gonna get slit from sack to throat, hunty! (JK btw, honest mistake and I have no recollection of who it was). Thanks for clarifying.
 
It is an opioid yes, but because of it’s peripheral nature, we can bypass the semantics, for purposes of our discussion lol.

I never used alone really, usually with a gabapentoid for WD. However an Oxy habit of about 150mg a day, was significantly helped by 30mg Lope. Not just liquibowel, but yawning, temp changes, shivers, all but gone.
 
Hey KS78! I understand your question and I've actually come to the same conclusion as some of the other people before me have. I think that Loperamide (Immodium) is just another Opioid and doesn't exert any major effects in the body outside of its role as a peripheral Opioid agonist. Correct me if I'm wrong science guys, but I think this explains things.

Morphine (Full Agonist) + Loperamide (Peripheral Agonist) = Morphine and Loperamide

Cocaine + Alcohol = Cocaine and Alcohol and benzoylecgonine, a third and distinct product

not all drug reactions produce synergistic effects like the ones in the latter reaction. I am typing this from a tablet and I know this is probably very rudimentary, but I thought it was worth a shot
 
Spot on really @Keif' Richards 👍. One day I am sure a lab somewhere, will definitively prove the amount of BBB crossing of lope, and/or if occupying peripheral receptors, boosts a typical agonist in its brain agonism!!
 
ChemicallyEnhanced said:
Omeprazole potentiates opioids?! GODAMN IT I have a script for that and have been not taking it because I thought it would have the opposite effect. Someone on here told me that the less acidic your stomach was, the less opioid was absorbed (or something like that).
Click to expand...
Nothing will truly potentiate things like yall want but certainly not omeprazole. The only real benefit cimetidine or omep or any other enzyme inhibitor would be more of the drug stays in your system SLIGHTLY longer. You will most certainly not get a true boost in rush or magic returning if you're an actual addict, maybe if you're a total noob
 
Kurt Cobain said:
Nothing will truly potentiate things like yall want but certainly not omeprazole. The only real benefit cimetidine or omep or any other enzyme inhibitor would be more of the drug stays in your system SLIGHTLY longer. You will most certainly not get a true boost in rush or magic returning if you're an actual addict, maybe if you're a total noob
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Ahh, that sucks. Definitely not a n00b. Been on perpetually on opioids since 2011
 
ChemicallyEnhanced said:
Ahh, that sucks. Definitely not a n00b. Been on perpetually on opioids since 2011
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Your best bet is to wait as long as you can before doses and even then man the magic won't be like it was, it never will be for us again. You could take things like benzos or stimulants to try and add to the euphoria but they'd have to be low doses of all compounds and IF YOU'RE NOT EXPERIENCED AND I MEAN SUCKING DICK SO YOU AIN'T SICK EXPERIENCED 😭😂 DO NOT MIX OPIATES WITH ANYTHING ESPECIALLY BENZOS AND STIMULANTS
 
ChemicallyEnhanced said:
Ahh, that sucks. Definitely not a n00b. Been on perpetually on opioids since 2011
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You could try switching to this shit called SR something it's just a bunch of numbers type in opioid withdrawal substance SR and something should pop up on duck duck go. It's typically used to come off of stronger opiates. It's an opioid itself but nothing good lol it should just keep u out of wd or in minor wds. You could do that for a week say and then go back to ur DOC but be careful until you understand how far that would actually drop your tolerance.
 
Well the general risk is going from high to low very quickly confusing your body, stressing it out and potentially causing misfires to vital functions resulting in death, seizures, strokes, heart attack ect ect. If you're healthy rn with no issues, you're not an idiot or a young kid and you're fairly experienced with both substances on their own you will more than likely be fine at such low doses.
 
ageingpartyfiend said:
What's the problem mixing say 10mg oxycodone with 10mg Dexamphetamine or 15/20mg Methylphendiate?
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Be even more careful with stimulant based drugs like coke and Ritalin, they fuck your body up way more than an amphetamine based compound at least ime which I have a lot of but I also have very bad ADD so it effects me different. I don't like Ritalin or any drug like it really it makes me calm mentally but my body restless and jittery but still incredibly lethargic. Amphetamines suit me much better
 
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