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long term side effects: low dose, high frequency vs high dose, low frequency

brainsN'thumbs

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Oct 29, 2009
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after years of lurking, finally, MY FIRST POST!!!

so here's the question folks...
I'm sure you're all aware of the subtle (mostly positive :)) changes in the psyche that result from moderate psychedelic experimentation. I was just wondering whether more, lower-dose trips or fewer, higher-dose trips are more likely to permanently affect the user. I know that there is no "exact answer" to this question but any observations and/or speculation are welcome!
 
1 trip can change your life in a very powerful way.....

Probably depends more on the person, and how much you decide to take from the experiences and how you go about them....

Not all changes are subtle, i went from being a pretty depressed individual who saw nothing but the bullshit in life to someone who is in love with life. That depression probably would have driven me to suicide if something did not change.

LSD was the catalyst to that change.
 
i would say definitely the high dose low frequency would have more impacts on ones life

strong trips are usually the ones which illicit the most obvious changes, usually for the better sometimes for the worse

as an example... say you had a gram of 2c-t-7... and you've decided you're going to eventually consume all of it yourself

to extrapolate to the two extremes... you could do 1mg a day for 1000 days and never experience any effects whatsoever... and therefore no changes

or you could take the entire gram at once and likely die.... that's a huge (negative) life-altering change :D
 
well, you guys are kind of talking about 'main effects'

the title of this thread is 'side effects'

which i would guess are more noticeable after high frequency low dose use (tolerance, depression, depersonalization)
 
Def the low-but-frequent one. After a couple of months of tripping pretty much every weekend, I noticed myself gradually becoming ever more distant. A single high-dose trip, while potentially shattering, at least notifies you that things are changing - the gradual changes with long-term, sustained use are more subtle and very difficult to detect.
 
My two cents.

Repeated low dosages seems to create a lot more physical side effects in terms of hallucinations while not on psychs and generally fits within a slow transformation model, whereby to some extent you are tripping slightly all the time. There was a time period of nearly two years where I would never even see blackness while shutting my eyes - but rather an explosion of colors, faces, forms, essentially instant dreaming with just the lack of direct visual stimulus.

High but infrequent dosages, meanwhile, never seemed to have the longterm aspect associated with them UNLESS there was some vastly significant mental breakthrough (whether for good or ill). This is more mentally based, however.

That explanation sucked. Maybe I can explain this better more technically.

So for example, large infrequent doses are less likely to create the "permatrip" - defined by the brain learning to frequently use certain mental pathways associated with the trip experience. The constant use of these pathways even at small doses becomes a neural habit, and therefore you are more "permatripped" as a result. However, large doses will create imprint vulnerability. This means, if I imprint "smoking is bad" "I should be a more caring person" or "demons live in the alley outside my house" that imprint is more likely to stick - just because that's how our memory defines itself in such a vulnerable moment. Even though it might not stick in terms of a psychosis or compulsion, I might suddenly not crazy cigarettes as much, or I might find myself unduly nervous every time I walk by that alley. The repeated low doses can potentially cause your brain to be conditioned to certain ways of thinking (including hallucinating). The high doses, if infrequent, are not going to cause this learned behavior, but could potentially trigger an imprinted mental phenomena.

My experiences.
 
I was just wondering whether more, lower-dose trips or fewer, higher-dose trips are more likely to permanently affect the user.
\

I think 1 high dose mind blowing experience is more likely to catalyze positive change than frequent loe dose trips. (only if yo arent predisposed to mental illness)

Frequent low dose trips are more likely to cause negative change like HPPD or just being slightly delusional from spending too much time in psychedeoic space.

that has been my experience. each indivsual may have different opinions on this.
 
Im a fan of frequent low dosing over infrequent high doses. I find that using psyche's reguarily (ie. ounce a week, alternating between a range of differant chems) allows you to assess what happened during a trip and how that impacts you. Make subtle changes to yourself as a result and trip again a week later for a re-assesment, and the cycle continues.

Then again, I dont use psychedelics just for pleasure, they're highly thereputic to me as well and I more often than not trip to better myself.

This allows me to make positive changes to myself over a period of time, instead of simply being overwhelmed by a substance and forced into facing issues there and then, which would undoubtedly cause rather drastic changes over a very short period of time which some people might view as a bad thing.

My opinion.
 
Everyone is different mentally and chemically.

MDMA was a catalyst for HPPD for me, and HPPD is not a fun side effect. My suggestion is to keep doses AND frequencies as low as possible. Theres not really any warning signs for if psyches are going to effect you in a negative way, and for a very long time.
 
a bad trip can change your life forever. normal trips ive noticed have just changed my perspective on life. it has made me more happy nd willing to live and enjoy life. ive also noticed after eating quite a lot of psychedelics, namely acid, that i'll get hallucinations when im completely sober. like almost everyday ill wake up with chipmunked pupils and lighttrails. when its dark or when i stare at something, it slowly starts moving. i feel like after eating a lot of psychedelics, you aren't in reality anymore. youre living in the psychedelic realm. that's why ive cut down a bit on these drugs.
 
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