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long term effects of Ketamine & simular chemicals

farmaz

farmaz

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I have been looking on the net for long term medical reoprts on the use of Ketamine, MXE & 4MeO PCP

I cant seem to find any real reports that have medical notes or such like on the effects on the brain. I have seen plenty of stuff that gives a small outline of what to expect but nothing thats really in depth with case studys etc.

"Cognitive impairments and memory problems are the most common neurological long-term effects of Ketamine and its chronic abuse. Long-term users tend to develop verbal short-term and visual memory impairment. However, the occasional use of the drug appears to be less harmful and the damage that may result appears to be reversible. However, there is still the possibility that the user will suffer with depression even though they have abstained from Ketamine use"

Also I have been using WAY too much 4Meo pcp & when mxe was still legal I must have used several oz (I lost count at 56 grams) as mxe & pcp are different in their chemical build will they still effect the brain in the same way?

Sorry I am not a doctor or medically wise on these things btw
 
That's a massive amount of MXE to go through. It takes me 5-6 days to go through 1g and thats near constant use. Anyways I think the biggest risk is to have a psychotic break, not necessarily get brain damage or anything. If you are concerrned about brain damage or any type of negative effects, I'd cessate use of the 4-MEO-PCP. PCP has been shown to be neurotoxic, in contrast to ketamine. The neurotoxicity may arise from the piperidine functional group (one can predict that this greatly hinders metabolization/excretion).
 
g0to said:
That's a massive amount of MXE to go through. It takes me 5-6 days to go through 1g and thats near constant use. Anyways I think the biggest risk is to have a psychotic break, not necessarily get brain damage or anything. If you are concerrned about brain damage or any type of negative effects, I'd cessate use of the 4-MEO-PCP. PCP has been shown to be neurotoxic, in contrast to ketamine. The neurotoxicity may arise from the piperidine functional group (one can predict that this greatly hinders metabolization/excretion).
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I know it is alot, I feel bad to be honest with the levels with which I hit it. The 1st time I ever did any I did 1 gram to myself & Iadmit mylife kind of went out of control & I did have a kind of breakdown mentally after a few sessions.

I find with those type of chemicals I feel "free" in my soul, in everyday life I dont feel like I can function & when I take these typesof chemicals it is like a huge weight has been lifted off my soul & I can be myself while under their effect. I have dealt with all types of issues in my life from things from my childhood such as abuse & also certian aspects of my sexuality which have caused me many years of pain.

I used to eat LSD in such huge doses but when I found Ketamine I truly felt like I was "free" in my mind, but looking back I think I may have done a bit too much.

At my "worst" points to do 1 gram of MXE in a day was nothing, the 1st time I did 4 meo pcp I got through 500mg in 2 days as I was not 100% sure of the substance but now I am getting the same with it.

Maybe now people can see why I was asking about long terms mental effects as I have done way too much.

I must add I have done dxm 3 times but HATED it, that substance is foul, burning skin & a itch that is worse than good heroin IMO
 
ketamine is known to cause severe bladder damage. even though mxe has been marketed as "bladder-friendly", large amounts may cause the same problems as ketamine
 
- Ketamine has the bladder / urine tract damage, the dissociative effects can have a major impact on memory, language and other cognition related faculties if that is chronically "scrambled" but I would not call that true damage, but rather persistence of fading effects and atrophy of unused or dysfunctional mental faculties.
- Something like 4-MeO-PCP may contain harmful impurities which is not really an issue with K as long as the product is not cut and/or misrepresented
DXM is a hard one, it really feels to me like long-term use would cause some damage or instability perhaps from the serotonergic action... but what evidence do I have? Nothing on hand, that's for sure.
- Stuff like 3-MeO-PCP or 3-MeO-PCE that is more dopaminergic - same goes for MXE - is perhaps risks of tendencies towards the manic, then also the opposite, so imbalance in mood or motivation... again all of which is conjecture and not proven.
 
ParappaTheRapper said:
^yea. I've never done ketamine, but according to this documentary http://www.youtube.com/watch?v=6QGl9Pwl2RI, it eventually makes you piss blood and lose hair.
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Forget the televised bullshit. The toxicological data on ketamine can be found on the internet with enough searching. It doesn't make you piss blood, but it will damage your bladder and/or gall-bladder if used at high enough doses for a long enough time.

Making your hair fall out? It sounds like they just pulled that right out of their asses.
 
Solipsis said:
...the dissociative effects can have a major impact on memory, language and other cognition related faculties if that is chronically "scrambled" but I would not call that true damage, but rather persistence of fading effects and atrophy of unused or dysfunctional mental faculties...
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That makes sense to me. The evidence that NMDA antagonists result in direct neuronal damage is pretty weak. IMO, it's more likely that the observed "neuropsychological toxicity" is not due to neuronal damage per se, but rather reflects the atrophy incurred through chronic inebriation. The brain is like a muscle, in that if it is not "exercised" by participating in life in a functional way, it will lose its edge...sometimes to such an extent that there is obvious cognitive impairment, in which case, the process is likely difficult to reverse.
 
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