What would be the possible long term health effects of regular 2c-t-7 use, and how would this differ if combined with other drugs? I have heard 2c-t-7 causes some serotonin release, is this true and if how regular would use have to be for this to be problematic?
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Long term effects of 2c-t-7
- Thread starter joe456
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sekio
Bluelight Crew
How regular? What other drugs?
The mode of action of 2c-t-7 is pretty poorly characterised, but it is likely to act mainly as a serotonin receptor agonist.
Receptor affinities for 2c-t-2, a related drug -
So 2c-t-2 doesn't interact with SERT (serotonin transporter). It does interact with a variety of serotonin receptors.
One worrying datapoint is the high affinity for 5HT2B - stimulation of this receptor is known to cause heart valve hypertrophy with daily, continuous, high-dose use.
Don't get into the habit of tripping daily. If used in moderation 2ct-7 should be very physically safe. If used daily it is probably considerably less safe and carries risks of heart damage.
The mode of action of 2c-t-7 is pretty poorly characterised, but it is likely to act mainly as a serotonin receptor agonist.
Receptor affinities for 2c-t-2, a related drug -
PLoS ONE Psychedelics and the human receptorome said:
So 2c-t-2 doesn't interact with SERT (serotonin transporter). It does interact with a variety of serotonin receptors.
One worrying datapoint is the high affinity for 5HT2B - stimulation of this receptor is known to cause heart valve hypertrophy with daily, continuous, high-dose use.
Don't get into the habit of tripping daily. If used in moderation 2ct-7 should be very physically safe. If used daily it is probably considerably less safe and carries risks of heart damage.
The 5HT2B concern goes for most psychedelic drugs - most of them act on both 5HT2A and 5HT2B, and so they present a cardiac hazard (al la phen-fen) with continuous heavy use.
The big question of course is how relevant that is - and that is hard to judge. The Phen-fen patients were taking fairly large doses of a prodrug of a very strong 5HT2B agonist, and they were taking it every day. Plus, they were people who were taking powerful prescription medication for obesity - which is a demographic not known for cardiac health; they were probably particularly vulnerable, and they were taking it with a mainly-peripheral stimulant. However, though this was a bit of a perfect-storm for heart valve damage, it caused detectable heart damage to double-digit percentages of patients within a few months (I don't have the paper handy, but it's out there) - this side-effect was not rare.
The big question of course is how relevant that is - and that is hard to judge. The Phen-fen patients were taking fairly large doses of a prodrug of a very strong 5HT2B agonist, and they were taking it every day. Plus, they were people who were taking powerful prescription medication for obesity - which is a demographic not known for cardiac health; they were probably particularly vulnerable, and they were taking it with a mainly-peripheral stimulant. However, though this was a bit of a perfect-storm for heart valve damage, it caused detectable heart damage to double-digit percentages of patients within a few months (I don't have the paper handy, but it's out there) - this side-effect was not rare.
Thanks, very interesting replies, and I currently take it once a week at raves, but will probably take an occasional smaller dose midweek. As for dosage sadly I can't give any meaningful dosage since it is very mixed down, at least its mixed down very evenly, when I first found out how weak it was compared to it pure I was worried there would be inconsistent strength within the same wrap which hasn't been a problem. I take enough to cause a lot of pupil dilation and jaw clenching (If its somewhat cold) and to see things glow brighter and get an MDMA like loved up feeling stronger than with MDMA, this description may be a bit misleading since I don't get any more visuals than this with high doses of MDMA combined with a lot of weed that give many of my friends visuals, even if they don't look as fucked as I do lol. As for what other drugs, I was thinking more generally since I've heard combinations that may not even sound like they have the potential to be more harmful, well at least not to me lol, like ketamine can make it significantly more harmful because 2c-t-7 is a MAOI. While it would be useful to know any drugs that would make it more harmful, I would be most likely to mix it with cannabis, tobacco, ketamine, NOS, caffeine, speed or alcohol, obviously being extremely careful with stimulants as I can get some jaw clenching anyway.
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lolusername
Bluelighter
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2c-t-7 combined with stimulants is a bad idea, its done people in before in the past. Honestly I'd just stick to smoking weed on it if you have to mix.
I would consider switching up which psychedelic I took week to week, if I was tripping every week. There is certainly going to be tolerance observed week to week (much more if you trip mid-week too), and the tolerance will be less pronounced if you switch off between different psychedelics. Tripping weekly will also likely result in persisting visual effects when sober after a month or two (regardless of what psychedelic you take), though this usually goes away if you stop tripping for a while. I would avoid the mid-week low dose.
Ketamine is not contraindicated in combination with weak MAOI's. I wouldn't be afraid of that combo.
MDMA and real stimulants are strongly contraindicated in combination with weak MAOI's - they should be carefully avoided.
Alcohol, cannabis and nitrous do not pose any particular concerns, nor does caffeine in reasonable doses.
I recommend you take care to use these drugs responsibly.