dopamimetic
Bluelighter
- Joined
- Mar 21, 2013
- Messages
- 2,072
The only paper I know of about this topic is now around 7 years old and while they https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713393/
Shouldn't the lowered shizo like NMDA density many are raving about induce a negative tolerance to dissos while we see a positive one, and one which reaches stratospheric dimensions?
From my own not-so-scientifical experiences, both is true. This makes the 'loss of magic' phenomenon many experience at some point when over doing dissociatives.
Yet, I found alcohol to be more euphoric than it was for a long time, and less sedative than ever - together with feeling not unlike early lower 2nd plateau DXM trips.. Which I do blame more the opioids for than dissos but this might be a bias.
Do either dissos and/or opioids (the latter might explain why so many people in metha maintenance begin to abuse benzos at some point) lower the production of GABA or mess with it in another way??
I know that ketamine is associated with loss of 'rapamycin' which apparently means GABAergic interneurons but never read anything about opioids when they are known to increase nmda density.
Shouldn't the lowered shizo like NMDA density many are raving about induce a negative tolerance to dissos while we see a positive one, and one which reaches stratospheric dimensions?
From my own not-so-scientifical experiences, both is true. This makes the 'loss of magic' phenomenon many experience at some point when over doing dissociatives.
Yet, I found alcohol to be more euphoric than it was for a long time, and less sedative than ever - together with feeling not unlike early lower 2nd plateau DXM trips.. Which I do blame more the opioids for than dissos but this might be a bias.
Do either dissos and/or opioids (the latter might explain why so many people in metha maintenance begin to abuse benzos at some point) lower the production of GABA or mess with it in another way??
I know that ketamine is associated with loss of 'rapamycin' which apparently means GABAergic interneurons but never read anything about opioids when they are known to increase nmda density.