PINKoPANaTHER and Pharmokinetictal,
I appreciate that but clonazepam is such a gruesome drug ... I'm fairly sure that my health is in play as well, although I'm not sure what exactly is going on. And the drug has a nasty effect/side effect profile, 'mixed' if not paradoxical effects. Pharmacokinetics/ probably plays a role as well.
The point is that clonazepam is my problem drug. It's not easy or neutral by any means.
Regarding subunits: I already have full tolerance/dependence to clonazepam. I have full tolerance to the hypnotic, amnestic and sedative effects of lorazepam. Diazepam still has some sedative properties, I have taken it for only a few days.
I'm very sensitive to when I take the clonazepam, I have to take it in the evening. It's a hardcore dependence ...
'I'm against Valium as a tapering agent because it IS 'dirty.' Diazepam alone does not have a particularly long half life. It's fast acting but is quickly oxidized and reduced to much less efficacious metabolites like oxazepam and nordiazepam and desmethyldiazepam. As a drug alone, diazepam is great...but it's lipophilicity makes it a terrible prodrug to metabolites that are even less effective and now exist mainly plasma protein and lipid bound at insignificant quantities.'
Diazepam's half life, at the top of my head, 1-2 days ? Long enough. 'duration of action' is a different matter. It seems to matter for some people, not for others.
It is dirty, though. It indeed accumulates up to 5-8 times the daily dose (I guess that makes for an 'effective' half life that is longer?), which makes it difficult to adjust the taper. The desmethyldiazepam also accumulates into fat, and indeed desmethyldiazepam/diazepam together tends to require very slow tapers, with difficulty in making adjustments. And what if you lose body fat ? ... Release of 'benzo' Btw, nordiazepam=desmethyldiazepam ...
Any opinions about Tranxene ?
I appreciate that but clonazepam is such a gruesome drug ... I'm fairly sure that my health is in play as well, although I'm not sure what exactly is going on. And the drug has a nasty effect/side effect profile, 'mixed' if not paradoxical effects. Pharmacokinetics/ probably plays a role as well.
The point is that clonazepam is my problem drug. It's not easy or neutral by any means.
Regarding subunits: I already have full tolerance/dependence to clonazepam. I have full tolerance to the hypnotic, amnestic and sedative effects of lorazepam. Diazepam still has some sedative properties, I have taken it for only a few days.
I'm very sensitive to when I take the clonazepam, I have to take it in the evening. It's a hardcore dependence ...
'I'm against Valium as a tapering agent because it IS 'dirty.' Diazepam alone does not have a particularly long half life. It's fast acting but is quickly oxidized and reduced to much less efficacious metabolites like oxazepam and nordiazepam and desmethyldiazepam. As a drug alone, diazepam is great...but it's lipophilicity makes it a terrible prodrug to metabolites that are even less effective and now exist mainly plasma protein and lipid bound at insignificant quantities.'
Diazepam's half life, at the top of my head, 1-2 days ? Long enough. 'duration of action' is a different matter. It seems to matter for some people, not for others.
It is dirty, though. It indeed accumulates up to 5-8 times the daily dose (I guess that makes for an 'effective' half life that is longer?), which makes it difficult to adjust the taper. The desmethyldiazepam also accumulates into fat, and indeed desmethyldiazepam/diazepam together tends to require very slow tapers, with difficulty in making adjustments. And what if you lose body fat ? ... Release of 'benzo' Btw, nordiazepam=desmethyldiazepam ...
Any opinions about Tranxene ?