• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Lit request: The Netherlands XTC Toxicity (NeXT) study

The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy.
Click to expand...

Yeah, maybe they'll come up with a flashy postcard like NIDA did showing a brain damaged by ecstacy. Sounds fab!
 
Can't be very good, seeing as it got published in a journal that isn't even rated on any citation report site.

Oh I see, it's just a report on what they're GOING to do, study completion date, mid 2006, so we wont see this published until the end of this year at the earliest.

http://www.clinicaltrials.gov/ct/sh...onid=79841B84A5947BAA320D34BF4C8D0482?order=4

Anyway, I "have" access to that journal online, however it keeps saying that the most recent issue that is published is 14(3) Sept. I'll check back in a couple of weeks, and see whatsup.

If you want I can also order a paper version and send it to you.
 
It's not a big deal, I suppose, since it's not even actual results yet. I'll have access to it myself in a couple months (our digital subscription has a three-month embargo), just hoping somebody had immediate access for the sake of immediate gratification. :-)

I'm optimistic that this study will yield very significant data. Repeated scans of 'in the wild' ecstasy user's brains before and after use could shed a great deal of light on the question of neurotoxicity. The tracking of cognitive function and emotional health should also be very interesting, particularly as usage patterns correlate to psychopathology.
 
Anyone know what kind of MDMA dosage they are using for the standard? The results wouldn't be all that reliable without a standard formula, but then again they wouldn't necessarily be all that valid to real life if they didn't factor into it the shit that goes into some of those pills. A bit of a catch-22 that you get from prohibition...I'll get off my soap box now...
 
This study implies that even one time of MDMA can cause lasting memory deficits.
http://archpsyc.ama-assn.org/cgi/reprint/64/6/728.pdf
Results: At the initial examination, there were no statistically significant differences in any of the neuropsychological test scores between persistent Ecstasy-naive subjects and future Ecstasy users. However, at followup, change scores on immediate and delayed verbal recall and verbal recognition were significantly lower in the group of incident Ecstasy users compared with persistent Ecstasy-naive subjects. There were no significant differences on other test scores.

Conclusions: Our findings suggest that even a first low cumulative dose of Ecstasy is associated with decline in verbal memory. Although the performance of the group of incident Ecstasy users is still within the normal range and the immediate clinical relevance of the observed deficits
is limited, long-term negative consequences cannot be excluded.
Click to expand...

The study has been criticized here, also including the response by study authors here.

Any more comments, criticisms, insights?
 
You must log in or register to reply here.
Top