List on all the supplements that you found blocking the effect of drugs

[Lordallmighty]

A big issue ive been having is having to stop supplementation x days pre roll/shrooms to avoid it blocking the effect

This have happends so many times now that it drives me almost insaine.

The nr.1 supp that most people know of that blunt the effect is NAC. It seems like supplements that work on normalizing glutamate is whats making the drugs not work (and MAO A). It even blunts the dopamine from caffeine

As someone with joint pain, i really wanna use MSM/DMSO but the half life is so long that i will need to stop 2-3 weeks before. MSM creates cysteine (NAC) so it would make sense that msm block the effect as well then. Anyone else uses msm/DMSO for joint health?

For most its enought to stop NAC 2-3 days before roll (like you see on reddit) but for others they need to wait min a week. Yet the half life is short, vs msm

Acetyl carnitine and vitamin C the same day as roll ive seen people say reduce the effect/high as well

How do you guys feel about this and what have you found to reduce/block the effect and what supplements do you need to stop X days pre roll ?

Regards

 

[SuperPsych]

NAC blocked the effects of dissociatives (MXPR to be exact) for a week off of a single dose. If I was using NAC regularly I'd have to stop for a couple of weeks to REALLY feel the dissociative. I haven't tried it with other substances that I can remember

 

[Lordallmighty]

NAC blocked the effects of dissociatives (MXPR to be exact) for a week off of a single dose. If I was using NAC regularly I'd have to stop for a couple of weeks to REALLY feel the dissociative. I haven't tried it with other substances that I can remember

Wow... even worse then i tought. thanks for input

Have you noticed minerals reduce effect? mag works on NMDA/glutamate similuar as NAC. Gonna dose shooms tomorrow cant fail 5th time in a row this this time again. Did a microdose shrooms yesterday and it seems to work, been 3 weeks since MSM. Got bad joint pain from 0.6g mushrooms and mag totaly took it away. but dosed post "high" so dont know if the effect was reduced

 

[SuperPsych]

I haven't heard or experienced minerals altering the experience of any psychoactive. Magnesium does work on the NMDA receptor but not powerfully enough to alter the experience. I've used magnesium glycinate to try and fall asleep after a dissociative experience and it didn't alter the experience, but it did help me get to sleep quicker (mixed with a ton of other supplements). Agmatine can alter the effect of kratom. I notice basically zero effect from kratom while using agmatine. I assume that it blocks the effects of other substances. Racetams block the effects of NMDA antagonists and can actually be used to abort a dissociative trip. I've also used to use noopept years ago when using amphetaminnes. When I'd start seeing shadows move and would get tracers from being awake too long I'd take noopept and the delirium would seem to go away.

 

[Allylbenzene]

Agmatine can alter the effect of kratom. I notice basically zero effect from kratom while using agmatine.

Were you using agmatine with kratom or seperately?
Agmatine works as an alpha-2 adrenergic agonist, NMDA antagonist, sigma + Imidazoline agonist and via AMPA/mTOR (like ketamine). It also interacts with 5-HT2A.

 

[SuperPsych]

Were you using agmatine with kratom or seperately?
Agmatine works as an alpha-2 adrenergic agonist, NMDA antagonist, sigma + Imidazoline agonist and via AMPA/mTOR (like ketamine). IT also interacts with 5-HT2A.

I've done both with and without kratom

 

[Allylbenzene]

I've done both with and without kratom

Agmatine is probably best used seperate from kratom. It has potential to improve general health and reduce accumulated tolerances (partly via NMDA antagonism, AMPA and mTOR like ketamine).

 

[Mycophile]

I've done both with and without kratom

So if you are using Agmatine to reduce tolerance, can you take it at night after your Kratom has worn off without it blunting your effects to Kratom the next day, or will it still kill all the euphoria?

And if you are taking Agmatine regularly, how long would you have to go without it for Kratom to start working again?

My Kratom tolerance is just too high and I'd like to lower it so that it will work better and/or find a potentiator that works well, but none of them really seem to do the trick. IF I could take Agmatine at night for a week or two to lower my tolerance and still get Kratom effects the next day that would be ideal, but I'm not sure that's possible.

Also, what dosage of Agmatine do you take?

 

[SuperPsych]

So if you are using Agmatine to reduce tolerance, can you take it at night after your Kratom has worn off without it blunting your effects to Kratom the next day, or will it still kill all the euphoria?

And if you are taking Agmatine regularly, how long would you have to go without it for Kratom to start working again?

My Kratom tolerance is just too high and I'd like to lower it so that it will work better and/or find a potentiator that works well, but none of them really seem to do the trick. IF I could take Agmatine at night for a week or two to lower my tolerance and still get Kratom effects the next day that would be ideal, but I'm not sure that's possible.

Also, what dosage of Agmatine do you take?

I wish that I could answer that. I never took agmatine to reduce tolerance, I was taking it for depression while I happened to be addicted to kratom. I imagine if you took agmatine at night, then I dont think that it'd still block the kratom the next day but I'm not sure. If you take agmatine regularly I imagine you wouldn't have to wait too long before kratom became effective again. Maybe a couple of days? When I took it for depression, I'm pretty sure that I felt the kratom the day after I ceased the agmatine. I can't say for certain because that time period is kinda foggy. I was in a deep depression and depression really affects my memory.

I usually take between 1-2g of Agmatine for depression. For tolerance reduction, I am not sure the proper dose.

Have you looked into Ultra Low Dose Naltrexone (ULDN) ? It's probably the better option. Much more effective at reducing tolerance and doesn't block the effects if done right

 

[Mycophile]

I wish that I could answer that. I never took agmatine to reduce tolerance, I was taking it for depression while I happened to be addicted to kratom. I imagine if you took agmatine at night, then I dont think that it'd still block the kratom the next day but I'm not sure. If you take agmatine regularly I imagine you wouldn't have to wait too long before kratom became effective again. Maybe a couple of days? When I took it for depression, I'm pretty sure that I felt the kratom the day after I ceased the agmatine. I can't say for certain because that time period is kinda foggy. I was in a deep depression and depression really affects my memory.

I usually take between 1-2g of Agmatine for depression. For tolerance reduction, I am not sure the proper dose.

Have you looked into Ultra Low Dose Naltrexone (ULDN) ? It's probably the better option. Much more effective at reducing tolerance and doesn't block the effects if done right

I had a poster who was on here who I'd talk to but he unfortunately passed...He made me ULDN but I don't have much left. He explained how to make it, and I have full dose Naltrexone pills, but I just don't feel confident because even LDN will cause precipitated WD.

I also do have depression. Did you find that Agmatine helped? Cause Kratom helps when I'm not in WD, but I find it's not manageable to take in the long term for that purpose. It'll always stop working at some point and you have to stop to get tolerance back.

So you take 1-2 grams? I'm trying to figure out how much I'd purchase/take on a daily basis.

Well, if anyone else knows the answers to these questions, please chime in.

 

[SuperPsych]

I had a poster who was on here who I'd talk to but he unfortunately passed...He made me ULDN but I don't have much left. He explained how to make it, and I have full dose Naltrexone pills, but I just don't feel confident because even LDN will cause precipitated WD.

I also do have depression. Did you find that Agmatine helped? Cause Kratom helps when I'm not in WD, but I find it's not manageable to take in the long term for that purpose. It'll always stop working at some point and you have to stop to get tolerance back.

So you take 1-2 grams? I'm trying to figure out how much I'd purchase/take on a daily basis.

Well, if anyone else knows the answers to these questions, please chime in.

Volumetric Dosing is pretty easy. It just requires simple math. If you have 50mg Naltrexone pills, you can take half and dissolve it in 25mL of alcohol or something. You'll need some 1mL oral syringes. If you dissolve 25mg in 25mL then one full 1mL syringe is 1mg of Naltrexone. The oral syringes are marked so you'd be able to dose in microgram amounts pretty easily.

I actually do find that Agmatine helps. Kratom does help depression but only for a couple of days. That's how my kratom addictions always get started. I'll become depressed then start using kratom and before long the kratom is making my depression worse.
Out of all of the supplements tand nootropics that I've tried, Agmatine has had the most tangible effect on my mood. It's not a silver bullet but it does make me feel a bit better after taking it. You can get agmatine very cheap. I ordered 100g for less than $20. If you have a scale you can weigh it out or you can just fill gel capsules. A gel capsule will be roughly 500mg. I'd recommend maybe 500mg 3-4 times a day or 1000mg twice a day

 

[Mycophile]

Volumetric Dosing is pretty easy. It just requires simple math. If you have 50mg Naltrexone pills, you can take half and dissolve it in 25mL of alcohol or something. You'll need some 1mL oral syringes. If you dissolve 25mg in 25mL then one full 1mL syringe is 1mg of Naltrexone. The oral syringes are marked so you'd be able to dose in microgram amounts pretty easily.

I actually do find that Agmatine helps. Kratom does help depression but only for a couple of days. That's how my kratom addictions always get started. I'll become depressed then start using kratom and before long the kratom is making my depression worse.
Out of all of the supplements tand nootropics that I've tried, Agmatine has had the most tangible effect on my mood. It's not a silver bullet but it does make me feel a bit better after taking it. You can get agmatine very cheap. I ordered 100g for less than $20. If you have a scale you can weigh it out or you can just fill gel capsules. A gel capsule will be roughly 500mg. I'd recommend maybe 500mg 3-4 times a day or 1000mg twice a day

Ok, but if you take Agmatine at night after your last dose of Kratom wears off, do you find that Kratom will work for you the following day? Cause that's the biggest question I have.

And if not, how long do you need to stop taking Agmatine for the Kratom to work again?

Also, how many days do you think you need to take Agmatine in order for your Kratom tolerance to really go down?

Also, I take a few meds like Klonopin, prozac, Rosuvastatin and Solifenacin. Do you think that amount of Agmatine could be hard on my liver with all that stuff.

And do you need an oral syringe for ULDN or could you just use a typical dropper from like a liquid melatonin bottle or something? I'm also going to send you a PM...

 

[SuperPsych]

Ok, but if you take Agmatine at night after your last dose of Kratom wears off, do you find that Kratom will work for you the following day? Cause that's the biggest question I have.

I can't really give you a proper answer to that. Every day was a haze when I was attempting to treat my depression while also being addicted to kratom. My depression at that point was very severe and it affected my memory. I think that kratom worked the following day but I can't say with certainty. If I took agamatine along with kratom, the kratom would still work to keep my withdrawal at bay but it would provide no sort of high.

And if not, how long do you need to stop taking Agmatine for the Kratom to work again?

Not really sure. I imagine that 12-24 hours would be enough to start getting some effect back from kratom, unless maybe you were taking large amounts of agmatine for a long period of time.

Also, how many days do you think you need to take Agmatine in order for your Kratom tolerance to really go down?

I am unsure about that. It definitely wouldn't reduce your tolerance over night. You'd have to be taking it for a while but how long that would be, I dont know

Also, I take a few meds like Klonopin, prozac, Rosuvastatin and Solifenacin. Do you think that amount of Agmatine could be hard on my liver with all that stuff.

I don't know enough about Rosucastatin and Solifenacin to say for certain. Agmatine is something that your body has naturally so I don't think it would be too hard to process. 500mg-1000mg really isn't a large amount of something in the grand scheme of things. I think it'd be safe unless you have issues with your liver. The kratom you're taking is likely more hard on your liver than the agmatine would be.

And do you need an oral syringe for ULDN or could you just use a typical dropper from like a liquid melatonin bottle or something? I'm also going to send you a PM...

Absolutely do NOT use a dropper. You need very precise dosing with ULDN and the risk of getting too many drops with a dropper is too great. You can get oral syringes from Amazon. I got a box of 100 for less than $10 on there. It's well worth the investment

 

[Mycophile]

I can't really give you a proper answer to that. Every day was a haze when I was attempting to treat my depression while also being addicted to kratom. My depression at that point was very severe and it affected my memory. I think that kratom worked the following day but I can't say with certainty. If I took agamatine along with kratom, the kratom would still work to keep my withdrawal at bay but it would provide no sort of high.


Not really sure. I imagine that 12-24 hours would be enough to start getting some effect back from kratom, unless maybe you were taking large amounts of agmatine for a long period of time.


I am unsure about that. It definitely wouldn't reduce your tolerance over night. You'd have to be taking it for a while but how long that would be, I dont know


I don't know enough about Rosucastatin and Solifenacin to say for certain. Agmatine is something that your body has naturally so I don't think it would be too hard to process. 500mg-1000mg really isn't a large amount of something in the grand scheme of things. I think it'd be safe unless you have issues with your liver. The kratom you're taking is likely more hard on your liver than the agmatine would be.


Absolutely do NOT use a dropper. You need very precise dosing with ULDN and the risk of getting too many drops with a dropper is too great. You can get oral syringes from Amazon. I got a box of 100 for less than $10 on there. It's well worth the investment

Thanks. I appreciate your attempt at answering. I guess you just don't know about how it affects a Kratom high which is my biggest concern.

It actually is possible to use a dropper for ULDN, but it's just that I personally don't feel comfortable making it and I don't think I could get it that precise. This one poster on here who made me a solution before he passed gave it to me in a small dropper bottle, and I used it that way till it ran out. I mean I'm about 95% done with it and I used half a dropper today. But it's the actual making of the preparation I don't feel comfortable with. Maybe if I made it using the syringe you're talking about I could, but I'm not comfortable. Also, I didn't really even feel it was as remarkable for removing tolerance as everyone else said it was.

If anyone else sees this and does know whether or not they can take Agmatine and then feel Kratom the next day, please let me know.