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List of Long-Acting (Extended Release) Pain Medications...

d50416

Bluelighter
Joined
Apr 11, 2011
Messages
62
Location
(732) NJ
and some side-effects youve experienced with them.. im just curious to see whats out there and how people reaxt to it; describe the feeling you had when on them
 
Other than all the obvious ones, I consider Tramadol Instant Release to be an "extended release" medication, since the tramadol is slowly converted in to the powerful O-Desmethyltramadol over several hours. It gives me a solid 9-12 hours of analgesia once the O-Des starts kicking in at the 2 hour mark.

The only problem is that your unique level of CYP2D6 enzymes in your liver determines how much is converted. It works great for me, as I have multiple copies of that enzyme. People with regular amounts find tramadol a weak opioid, and ones with CYP2D6 deficiency find it useless.
 
Tramadol ER
Morphine ER
Oxycodone ER
Oxymorphone ER
If you count Fentanyl Transdermal systems as ER, which you certainly should.
Methadone acts like an ER but still requires chronic dosing (although so do some/most patients w/ ER meds)
Buprenorphine Transdermal systems

I dunno that's all I can think of right now.
 
Heroin was always my favorite (not recommended in spirit of harm reduction). Snort a good couple bags and I'd have 8-9 hours of no pain. Feeling relaxed and warm especially during the first 5 hours. Just floating along euphorically with the day. Like a bouy bouncing on the ocean not a care in the world. Only side effect is on your wallet which will lead to problems in other areas of your life. But if your a millionaire then heroin just might be for you!
 
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