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  • BDD Moderators: Keif’ Richards | negrogesic

List of GABA drugs in order of effect?

znb

Greenlighter
Joined
Jul 7, 2024
Messages
17
My GABA sensitivity is off the charts. My limit for pregabalin is 25 mg 2x a day. And even that I have to take a break from every 3-4 days because it builds in my system and causes severe ocular pain.

I tried smoke shop tianeptine and realized whatever it is in that stuff hits the GABA receptors in a similar fashion. Causes pain.

That being said I am fine with oxy which is prescribed for me. Kratom is ok. But what other pain reliving drugs effect GABA the least?

Can anyone list these drugs? Trial and error sucks.

Edit - for whatever reason Tramadol causes precipitated withdrawal. And fentanyl does nothing. Literally not a damn thing. Medical patches. It was scary.
 
I'm a little confused by this post. The opioids you mentioned don't really effect gaba primarily at all. And yeah pregabalin is a calcium channel inhibitor. Could you clarify?
 
I'm also confused. Does OP mean GABA or opioids?

Kratom also contains calcium channel inhibitors. So if you are sensative to lyrica, but not to kratom, it may be through some other mechanism.

Peronally, I never reacted well to tianeptine. But if you bought zaza, that often comes with other stuff in it as well such as phenibut.

Tramadol should not be causing precip withdrawal...

I think there may be something else going on.
 
opioids actually generally slightly decrease release of GABA and gabapentin/pregabalin only increase production of GABA by regulating enzymes but most effects are not mediated that way. Tianeptine is also SNRI in addition to being opioid and whatever I don't know too much about the stuff. And pregabalin/gabapentin do not act on opioid receptors, so whatever the culprit is, it probably is not about GABA activity or opioid receptor activity.

E: One thing I forgot; we can't be sure the smoke shop tianeptine did not contain anything other than tianeptine. I recall someone reporting in bluelight not too long time ago that they suspect some tianeptine they ordered somewhere containing some GABA agent. IDK. But I maintain my previous statement-tianeptine and pregabalin are drugs that have so much going on, we can not make hasty conclusions based on experiences with them.
 
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I was just laying out Rx pain relievers I have taken or have issue with.

Pregablin and gabapentin both cause the same issues. Ocular hypertension with pain eventually leading to hemorrhage. The first time it happened I thought I was having sinus issues. Until I was in so much pain I started crying and the tears were pink. My eyes almost didn't recover. They told me the side effect is "in the literature but no one on staff has ever seen it." I can only take small amounts (25mg x2 a day). If I go into withdrawal from an opioid I use no more than 75 for two to three days to bring me out of it.

When I tried that Zaza stuff I felt the same effect. And honestly, finding it in something from a smoke shop scared me.

I am in pain management for scar tissue binding and nerve damage. And I am naturally resistant to opioids, benzos, and whatever is in half the anesthesia out there. Never in my life have I ever stayed asleep through an entire surgery. Oral surgery, (not just for dental), gut surgery, spine and limb surgery. One time I woke up and asked for my purse. They refused to open me up again after that.

The tramadol was my idea, swapping down from morphine. (Yeah I know but I felt the change coming in pain management and I wanted to get ahead of it.) And an hour after I took my first dose, nose running, RLS, bowels turn to water, endless sneezing, and nothing, not morphine or oxy brought me out of it for hours. Didn't know what was wrong with me, I thought I had some sort of weird virus. My doc swapped me back to morphine immediately. He was so freaked out.

Just looking to manage pain in a world where suffering is considered noble or some shit. It isn't of course. I am a machine. You tell me something will help, I will do it. Physical therapy? Check. 3 times a week. Shrink for pain and trauma? Every week. I weighed 190 at 5'7 and I need to lose some to reduce pain? I weigh 130 now. (I did that in middle age btw). Kinda just getting desperate.
 
Tianeptine is also SNRI

Just as a point of clarity, tianeptine is definitely not an SNRI, having very low affinity for either the serotonin or norepinephrine transporter (thus, it's not an SNRI). Tianeptine has no direct serotonergic effects (as initially thought), and whatever weak serotonergic effects it might have occurs indirectly as downstream events.

Tianeptine most potent single action is on opioid receptors. It's antidepressant effects are contingent on mu opioid agonism.

But headshop tianeptine can have a variety of stuff in it. It's actually pretty shitty stuff. When I first found out that a headshop near me carried it, I thought, "oh shit, now in the back of my mind I'll know I can drive down the street and get tianeptine" -- which was a concern because I heavily abused tianeptine sodium in its pure form in the past and have been physically dependent on it before.

But I tried all the brands, even supposedly the "best" stuff, and the quality was so low, inconsistent (each bottle is different) and weakly dosed, that fortunately I don't hear it beckoning my name (in a manner that good, pure tianeptine powder would). I had to take a bottle and a half of what was the most expensive and "highest strength" stuff (based on reddit reviews) to get a decent, short lived high. I could have achieved the same effect with a few dollars of good pure powder. It's mind boggling hearing hillbilly stories of people resulting to robbery to pay for their outrageously expensive addiction to that underdosed junk.
 
Honestly, I'm not sure there's much that can be done when you have nerve damage. You could try looking into ketamine infusions (in a legit clinic, not with street ketamine). It's apparently effective for pain for a lot of people.
 
Hey @znb just wanted to say I meant no disrespect, when I posted my post I was barely able to type my hands were shaking so my response was short and when I looked at it again I thought it sounded disrespectful and your other post explained your issue more clearly.

Anyway I hope you find an answer and get some relief from your pain.
 
Hey @znb just wanted to say I meant no disrespect, when I posted my post I was barely able to type my hands were shaking so my response was short and when I looked at it again I thought it sounded disrespectful and your other post explained your issue more clearly.

Anyway I hope you find an answer and get some relief from your pain.
Actually, I could hug you. I knew that lyrica resembles GABA so in my head I thought it hit those receptors. It hits the alpha2-delta subunit of presynaptic voltage-gated calcium channels in the central nervous system.

Aka, my neurological genetic condition is causing the sensitivity! I have been trying to figure this out forever.

That's why I love this place. Knowledge. And kindness. Thank you again.
 
Tianeptine (I buy it online, not from head-shops, and it is the real deal), it FOR SURE has an effect on GABA in the way a Benzo does. I was on Clonezepam for over 10 years 2MG at 3 times per day, and when I failed a drug test (Oxy), they immediately took me off it at the doctor's shop saying I was going to die and they were going to get sued if they kept me on it. I went through the WORST Benzo WITHDRAWALS that not even Oxy could help. I ordered Tianeptine Sulfate in a large quantity, and 4 days later it arrived and saved my life. I had been having seizures and no matter what, they would not put me back on a Benzo medication. The Tianeptine Sulfate, I have been on 50MG at 3 times per day for 2 years now, and it feels like a LIGHT Clonezepam (maybe .5 at 50MG). So it is keeping me from the hell of Benzo withdrawal.
 
Tianeptine (I buy it online, not from head-shops, and it is the real deal), it FOR SURE has an effect on GABA in the way a Benzo does. I was on Clonezepam for over 10 years 2MG at 3 times per day, and when I failed a drug test (Oxy), they immediately took me off it at the doctor's shop saying I was going to die and they were going to get sued if they kept me on it. I went through the WORST Benzo WITHDRAWALS that not even Oxy could help. I ordered Tianeptine Sulfate in a large quantity, and 4 days later it arrived and saved my life. I had been having seizures and no matter what, they would not put me back on a Benzo medication. The Tianeptine Sulfate, I have been on 50MG at 3 times per day for 2 years now, and it feels like a LIGHT Clonezepam (maybe .5 at 50MG). So it is keeping me from the hell of Benzo withdrawal.
Freaking salt of the earth, some of these doctors. Any doctor that wilfully puts someone on SIX mg Clonazepam daily for a decade, and then abruptly takes them off like that, for failing one drug screen for oxy, should have their license removed, and have every red cent they've "earned" over the years taken from them and distributed directly to the thousands of people that have suffered from this negligence. I mean was this the exact same doctor putting you on and taking you off? Or just the same practice?

There is no circumstance that would ever warrant prescribing quite *that* much Clonazepam, anyway, tbh. Anyone that says differently has probably not seen exactly what that does to a person in the long haul, every single time. There is no gain that outweighs the negatives there, that's like a fundamental principle of treatment and prescribing. Really I could only see it ever happening in cases of severe epilepsy or a physical condition, even then I feel like it will cause severe problems at that massive dose, I've seen it and also lived it, it's not pretty. And yeah, oxycodone will likely never bring you much relief from severe benzo wd.

Some of the negligence I've seen displayed from the medical community tells me that a lot of people, parents, and taxpayers wasted a hell of a lot of money and time on schooling. Which is why I hate having to say "well I'm not a doctor😏"... Everyone knows that nurses are the pillars of the medical community.

But yeah sry on the rant, lol, regarding tianeptine it can be pretty good for anxiety I found too. For me though, i just found myself taking too much of it daily and not being consistent with it. So when you treat it like that, the diminishing returns are severe.

It sounds like you've worked out a pretty solid regimen, similar to how it would be prescribed anyway, so that's really good. Cause yeah full dependence on the opioid effects of it really sucks.

If you don't mind me asking, are you severely dependent on it? What happens if you skip a dose/day? Do you do tolerance breaks??
 
I came here because I wanted to help, then I got like three or four responses in and just gave up because I feel as though I would lose brain cells trying to help here. I'm sorry, but I just can't lol
 
I came here because I wanted to help, then I got like three or four responses in and just gave up because I feel as though I would lose brain cells trying to help here. I'm sorry, but I just can't lol
Helen Mirren Brain GIF
 
I can handle about 24 hours of "not being on Tia Sulfate." I think if it were the sodium, which is stronger, but has a shorter acting half life, it would be probably 8 hours or so. But I forgot it on a trip to my friends place 3 hours away over the weekend awhile back, and was really anxious. I was ok for the first 24 hours and then it slowly started to feel like a low grade flu with restless legs mixed in. I could not sleep. On day 2 I apologized to my friend, and they gave me a trip 3 hours back home (I didn't drive back). I got on the Tia Sulfate of 50MG, and pretty quickly the withdrawals went away. I ended up getting a ride from another friend go get my car back that next week. Lesson learned.

I have the stuff piled Tia in "Protein Powder" bottles in my car, in my house, at work, at my friends' places, etc. etc. I make sure I always have it around. I tried the withdrawal from the 6MG a day of Clonezepam after 10 years, and literally wanted to die until I got on Tianeptine and felt some sense of SELF and PEACE again.

I mean, some of this is my own fault for sure. I would not suggest anyone do what I did. I should have demanded a lower dose of Clonzepam or be asked to be taken off of it after a short time, but I was a dumb, young, combat veteran with PTSD, and this is what the US Army put me on, and the Veterans Affairs continued until my first failed drug test.

I was told by a doctor outside of the VA healthcare, that I should sue the VA for keeping me on that high of a dose for that long, but I just want to move on and not get caught up in the blame game. I am not not perfect. I think the doctor "meant well" for keeping me on it that long, and maybe after awhile, didn't want to go through the headache of having me come off of it the right way and have to totally jump off of it under their care. So, all of us in this took the path of least resistance, and even I do today with using Tianeptine to neutralize the withdrawals of Benzos.

Have you experienced long-term Benzo use yourself, and or have you heard of others who have been on too high of a dose and for too long being prescribed by doctors?

Thanks for the kind words!

Regards,
B

Note : I think Tia is a remarkable drug, but I would ONLY take the Sulfate kind and not go for the more hardcore sodium for long-term use.
 
I came here because I wanted to help, then I got like three or four responses in and just gave up because I feel as though I would lose brain cells trying to help here. I'm sorry, but I just can't lol
You are such a superstar! Just imagine being so arrogant to think you have all the answers for everyone else's life issues without really knowing the entire dynamic around why or how that person got to that point? I hope you have a good time staring in the mirror and jerking off in the morning to "what a brilliant human being you are!'
 
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