NatalieC1993
Greenlighter
- Joined
- Aug 5, 2018
- Messages
- 7
Hey Guys,
I am currently prescribed Low Dose Buprenorphine (0.5-3mg per day), Low Dose Gabapentin (800mg per day), specially compounded Ketamine nasal spray (5mg per spray), and Medical Marijuana for my treatment resistant depression. It is working astoundingly well so far. The only thing is--I would like to achieve opioid euphoria some days and the buprenorphine at any dose won't cut it. I have some tapentadols I ordered coming in, and I was wondering if I could counteract the NRI effects? I have taken tapentadol in the past before, and at dosages above around ~175mg, dysphoric, deliriant-like effects started popping up. I have been reducing my opioid tolerance through the usage of proglumide, ultra low dose naltrexone, and dissociatives, but, like I said, the buprenorphine just isn't euphoric enough. Back to the tapentadol--I have always loved its little sister tramadol quite a lot. For some reason, at any dose (even dangerous 1500mg dosages), I never became delirious on tramadol. I hypothesize that, although tapentadol has less serotonin releasing activity, it actually has more nor epinephrine effects than tramadol. I have a prescription that I never use for metoprolol (beta blocker). From my research, it has the ability to block nor epinephrine. What I am wondering is: if I take a normal dosage of metoprolol (12.5mg-25mg) with my tapentadol, do you guys believe that it will have enough anti-adrenergic activity to counteract the excessive re-uptake of nor epinephrine from the tapentadol thus reducing the dysphoric deliriant side effects and allowing the opioid effects to dominate? When my tapentadol gets in next week, I am planning on not taking any buprenorphine that day or the day before, as well as taking 300mg proglumide, 1mcg naltrexone, and 12.5mg metoprolol 30 minutes before the tapentadol to both potentiate its opioid effects and (hopefully) eliminate the horrible NRI effects.
What are your thoughts on this idea?
Sincerely,
Nat
I am currently prescribed Low Dose Buprenorphine (0.5-3mg per day), Low Dose Gabapentin (800mg per day), specially compounded Ketamine nasal spray (5mg per spray), and Medical Marijuana for my treatment resistant depression. It is working astoundingly well so far. The only thing is--I would like to achieve opioid euphoria some days and the buprenorphine at any dose won't cut it. I have some tapentadols I ordered coming in, and I was wondering if I could counteract the NRI effects? I have taken tapentadol in the past before, and at dosages above around ~175mg, dysphoric, deliriant-like effects started popping up. I have been reducing my opioid tolerance through the usage of proglumide, ultra low dose naltrexone, and dissociatives, but, like I said, the buprenorphine just isn't euphoric enough. Back to the tapentadol--I have always loved its little sister tramadol quite a lot. For some reason, at any dose (even dangerous 1500mg dosages), I never became delirious on tramadol. I hypothesize that, although tapentadol has less serotonin releasing activity, it actually has more nor epinephrine effects than tramadol. I have a prescription that I never use for metoprolol (beta blocker). From my research, it has the ability to block nor epinephrine. What I am wondering is: if I take a normal dosage of metoprolol (12.5mg-25mg) with my tapentadol, do you guys believe that it will have enough anti-adrenergic activity to counteract the excessive re-uptake of nor epinephrine from the tapentadol thus reducing the dysphoric deliriant side effects and allowing the opioid effects to dominate? When my tapentadol gets in next week, I am planning on not taking any buprenorphine that day or the day before, as well as taking 300mg proglumide, 1mcg naltrexone, and 12.5mg metoprolol 30 minutes before the tapentadol to both potentiate its opioid effects and (hopefully) eliminate the horrible NRI effects.
What are your thoughts on this idea?
Sincerely,
Nat