Opioids Light at the end of methadone tunnel

[ryanrhino]

After battle of going over from methadone to oxycotin I think I'm starting to get out of this funk. Long story short got down to 25mg methadone jumped to 30mg oxycotin much lower dose for me and hydromorphones for break through. I've jumped from 40mg and 4 8mg hydromorphones. What really screwed with me and I wonder how many others was that no matter how much hydromorphone I took this terrible feelings restless body runny nose ect would not stop. I found a nurse that was actually better then my "new" pain Dr. that explained that methadone to any pain killer is just plain different. That some people will withdraw no matter what and it takes around a month for some to equal out. I knew from reading methadone hits and binds more opiate reciptors aswell as NMDA affect causes restless leg/ restless body.
I just want to thank everyone for there support and compassion here. I know I'm not out of woods yet but today has been a better day the first in almost a month. I can't wait to sleep through a night again Once I get stable on this dose I'll start cutting my hydromorphone down but at least it seems attainable now.
Thanks everyone

 

[LeLouche]

I don't think that methadone is causing withdrawal symptoms that other opiods can't resolve.

Even though methadone is a synthetic opiod, it still works on the same receptors as all other opiods. A high enough dose of heroin/oxy/etc will take away any withdrawals you're having from methadone.

Also, the ndma receptors that activate actually help reduce building opiate tolerance. The effects l,d-methadone has on ndma is not causing you withdrawals.

 

[ryanrhino]

Methadone is different then other opiates and not just the long half life. Here are a few differences but at the same time some people may not be as sensitive to this differences. For one I'm the first patient of the pain clinic that had pitutary adrenal problems. A type of addisons caused by methadone. Brain receptors.. The majority of these receptors are classified at mu and delta receptors and a smaller percentage are NMDA. Nociceptive pain is primarily mediated by the mu receptors and neuropathic pain by delta and NMDA receptors; morphine binds to mu receptors only, while methadone binds to mu, delta and NMDA. Morphine does a good job of treating many types of pain, but because of methadones ability to bind to 100% of opiate receptors, methadone may do it even better. These differences due account in some people for withdrawl.

 

[BananasAndOranges]

I don't think that methadone is causing withdrawal symptoms that other opiods can't resolve.

Even though methadone is a synthetic opiod, it still works on the same receptors as all other opiods. A high enough dose of heroin/oxy/etc will take away any withdrawals you're having from methadone.

Also, the ndma receptors that activate actually help reduce building opiate tolerance. The effects l,d-methadone has on ndma is not causing you withdrawals.

Honestly Its really not that easy. Even when I was on 30mgs. Using Other opiates/oids never seemed to quite fill that ineasy void methadone gives you its almost paranoia and anger ...I just dont aggree

 

[ryanrhino]

BananasAndOranges thats how it has been for me, paranoia and anxiety/restlessness has been awful even running up hydromorphone and xanax does little. I'm very careful with the xanax the last thing I would want is to get off pain killers and then have a benzo problem. LOL