Evisceration
Greenlighter
- Joined
- Nov 12, 2013
- Messages
- 5
So basically, to make a long story short, my appetite has been extremely poor my entire life. Whenever I push myself with eating, I get nauseous. This has been evident since birth. All of my lab tests including blood work and thyroid are normal, I have no vitamin deficiencies and according to my physician, I'm extremely healthy. What is definitely apparent is that my appetite and anxiety are closely linked. Whenever any life stressor hits me, my appetite disappears. I'm also extremely irritable, prone to anger, obsessions, and I have been diagnosed with ADHD and Obsessive Compulsive Disorder. So obviously, something in my brain chemistry is a little off.
I have tried every natural solution possible. Megadosing all water soluble vitamins, various amino acids, probiotics, betaine HCL, 5HTP, Inositol, eating gluten/dairy-free and more. I will say that the vitamins and probiotics, along with living a stress-free life, do help slightly. I was in Greece for a summer with no stress, and just with vitamins and going gluten-free I was able to eat fairly normally. Not a lot compared to the average person, but more than I usually can. But maybe it was just placebo effect? Not sure.
I have been diagnosed with gastroparesis before (slow emptying of stomach), but was tested a second time and it came back negative. Perhaps I get gastroparesis like symptoms when anxiety kicks in, which would explain why I was negative at a later date?
The first time I was prescribed Zoloft, just 50 mg, my entire world changed. Bam, like that, after being on it for about 4 weeks, I was able to eat normally! Eventually I had to increase the dose to 100 mg, and then 150 mg, but after a couple of years on that, I experienced the "lack of motivation" of SSRIs. Later, in 2011, I tried mirtzapine for the first time, 15 mg. Wow, what a miracle drug this was. I was able to eat close to 5,000+ calories a day, which for someone like me, was absolutely insane.
The problem was, the mirtzapine stopped working after about 3 months. The appetite-increasing effects died down. Later on, I was able to get my appetite back while being on 100 mg zoloft, and 2 mg of abilify. The abilify caused that lack of motivation again, and exaggerated my ADHD symptoms. So I decided to get off all of that, and I restarted mirtzapine, about a year after I had last tried it. Bam, the mirtzapine worked again! For about 3 months, then again, the appetite increasing effects died off. So it seems like, I need to give mirtzapine like an entire year break before it works again, or maybe the abilify resensitized my 5-HT2 receptors? I'm not sure. The mirtzapine seems to downregulate the H1 receptors hardcore, it's a very powerful anti-histamine.
I would really like to get mirtzapine working again. I am currently on 60 mg of Cymbalta, which isn't increasing my appetite that much. It's causing tons of sexual side effects, along with lack of motivation. Mirtzapine worked really well for me and didn't cause any side-effects besides the morning hangover, it might have even increased my motivation a little bit. 75 mg of Seroquel does still knock me out, and provide a temporary appetite boost, but I don't want to rely on an anti-psychotic, for fear of side-effects, and also that the effects will go away.
Anyone have any ideas on how to resensitize the receptors so the mirtzapine will work again? I have only tried up to 30 mg before, but 15 seems to work the best for the appetite-inducing effects. Would 45+ mg doses work better? At this point, I feel like my only option is to wait another year, then cycle mirtzapine on one week, and off one week to keep the effects going, maybe while alternating with something else. If anyone has any other solutions, like a low-dose SSRI to combine with mirtzapine, let me know. Cymbalta doesn't seem to be working that well for me. But really, I would rather not be on something that I have to take all the time, if possible.
I have tried every natural solution possible. Megadosing all water soluble vitamins, various amino acids, probiotics, betaine HCL, 5HTP, Inositol, eating gluten/dairy-free and more. I will say that the vitamins and probiotics, along with living a stress-free life, do help slightly. I was in Greece for a summer with no stress, and just with vitamins and going gluten-free I was able to eat fairly normally. Not a lot compared to the average person, but more than I usually can. But maybe it was just placebo effect? Not sure.
I have been diagnosed with gastroparesis before (slow emptying of stomach), but was tested a second time and it came back negative. Perhaps I get gastroparesis like symptoms when anxiety kicks in, which would explain why I was negative at a later date?
The first time I was prescribed Zoloft, just 50 mg, my entire world changed. Bam, like that, after being on it for about 4 weeks, I was able to eat normally! Eventually I had to increase the dose to 100 mg, and then 150 mg, but after a couple of years on that, I experienced the "lack of motivation" of SSRIs. Later, in 2011, I tried mirtzapine for the first time, 15 mg. Wow, what a miracle drug this was. I was able to eat close to 5,000+ calories a day, which for someone like me, was absolutely insane.
The problem was, the mirtzapine stopped working after about 3 months. The appetite-increasing effects died down. Later on, I was able to get my appetite back while being on 100 mg zoloft, and 2 mg of abilify. The abilify caused that lack of motivation again, and exaggerated my ADHD symptoms. So I decided to get off all of that, and I restarted mirtzapine, about a year after I had last tried it. Bam, the mirtzapine worked again! For about 3 months, then again, the appetite increasing effects died off. So it seems like, I need to give mirtzapine like an entire year break before it works again, or maybe the abilify resensitized my 5-HT2 receptors? I'm not sure. The mirtzapine seems to downregulate the H1 receptors hardcore, it's a very powerful anti-histamine.
I would really like to get mirtzapine working again. I am currently on 60 mg of Cymbalta, which isn't increasing my appetite that much. It's causing tons of sexual side effects, along with lack of motivation. Mirtzapine worked really well for me and didn't cause any side-effects besides the morning hangover, it might have even increased my motivation a little bit. 75 mg of Seroquel does still knock me out, and provide a temporary appetite boost, but I don't want to rely on an anti-psychotic, for fear of side-effects, and also that the effects will go away.
Anyone have any ideas on how to resensitize the receptors so the mirtzapine will work again? I have only tried up to 30 mg before, but 15 seems to work the best for the appetite-inducing effects. Would 45+ mg doses work better? At this point, I feel like my only option is to wait another year, then cycle mirtzapine on one week, and off one week to keep the effects going, maybe while alternating with something else. If anyone has any other solutions, like a low-dose SSRI to combine with mirtzapine, let me know. Cymbalta doesn't seem to be working that well for me. But really, I would rather not be on something that I have to take all the time, if possible.
