SaciPerere
Bluelighter
- Joined
- Oct 24, 2013
- Messages
- 39
EDIT: I meant BLOCKING on title
Hello ladies and gents, even though this is SWIM's 1st post, SWIM has been a lurker here for many years. SWIM can usually find the answers for all his questions here, but there is a particular one I can't, and therefore created this account.
Anyway, SWIM is a hardcore veteran of most drugs: weed, cocaine, LSD, MDMA etc... but has never tried opioids before. Swim managed to get his hands on a box of pills of 50mg of codeine(pure, no Acetaminophen etc...) and, after reading the forums, decided to go for a 150 mg dose. After about 2 hours, SWIM didn't feel ANYTHING , so SWIM dropped another 150 mg, totalling 300 mg, which, from most accounts SWIM read, should be more than enough for a decent buzz, especially for someone who is opiate naive. But again, nothing happened. SWIM didnt even feel relaxed, sleepy, or other effects that are associated with opioids at low doses.
After doing some research, SWIM found out that LEXAPRO has the potential to completely block CODEINE, and SWIM has been on LEXAPRO for a good 2 years now (10mgs). SWIM would like to know if there are any ways to bypass this metabolic restriction, don't know, maybe chewing the pills, railing them, mixing with alcohol etc... or alternatively, for how long SWIM would have to quit Lexapro to get some nice opioid effects.. LEXAPRO has a half life of 32 hours, so SWIM assumes that going cold turkey on Lexapro for 3 days would be enough to drop some opioids and get a nice buzz? Tips are welcome!!
According to Wikipedia, this is the process through which SSRIs can block codeine conversion to morphine:
The conversion of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine and UGT2B7 conjugates codeine, norcodeine, and morphine to the corresponding 3- and 6- glucuronides. Srinivasan, Wielbo and Tebbett speculate that codeine-6-glucuronide is responsible for a large percentage of the analgesia of codeine, and, thus, these patients should experience some analgesia.[16] Many of the adverse effects will still be experienced in poor metabolizers. Conversely, 0.5-2% of the population are "extensive metabolizers"; multiple copies of the gene for 2D6 produce high levels of CYP2D6 and will metabolize drugs through that pathway more quickly than others.
Some medications are CYP2D6 inhibitors and reduce or even completely block the conversion of codeine to morphine. The most well-known of these are two of the selective serotonin reuptake inhibitors, paroxetine (Paxil) and fluoxetine (Prozac) as well as the antihistamine diphenhydramine and the antidepressant, bupropion (Wellbutrin, also known as Zyban). Other drugs, such as rifampicin and dexamethasone, induce CYP450 isozymes and thus increase the conversion rate.
Hello ladies and gents, even though this is SWIM's 1st post, SWIM has been a lurker here for many years. SWIM can usually find the answers for all his questions here, but there is a particular one I can't, and therefore created this account.
Anyway, SWIM is a hardcore veteran of most drugs: weed, cocaine, LSD, MDMA etc... but has never tried opioids before. Swim managed to get his hands on a box of pills of 50mg of codeine(pure, no Acetaminophen etc...) and, after reading the forums, decided to go for a 150 mg dose. After about 2 hours, SWIM didn't feel ANYTHING , so SWIM dropped another 150 mg, totalling 300 mg, which, from most accounts SWIM read, should be more than enough for a decent buzz, especially for someone who is opiate naive. But again, nothing happened. SWIM didnt even feel relaxed, sleepy, or other effects that are associated with opioids at low doses.
After doing some research, SWIM found out that LEXAPRO has the potential to completely block CODEINE, and SWIM has been on LEXAPRO for a good 2 years now (10mgs). SWIM would like to know if there are any ways to bypass this metabolic restriction, don't know, maybe chewing the pills, railing them, mixing with alcohol etc... or alternatively, for how long SWIM would have to quit Lexapro to get some nice opioid effects.. LEXAPRO has a half life of 32 hours, so SWIM assumes that going cold turkey on Lexapro for 3 days would be enough to drop some opioids and get a nice buzz? Tips are welcome!!
According to Wikipedia, this is the process through which SSRIs can block codeine conversion to morphine:
The conversion of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine and UGT2B7 conjugates codeine, norcodeine, and morphine to the corresponding 3- and 6- glucuronides. Srinivasan, Wielbo and Tebbett speculate that codeine-6-glucuronide is responsible for a large percentage of the analgesia of codeine, and, thus, these patients should experience some analgesia.[16] Many of the adverse effects will still be experienced in poor metabolizers. Conversely, 0.5-2% of the population are "extensive metabolizers"; multiple copies of the gene for 2D6 produce high levels of CYP2D6 and will metabolize drugs through that pathway more quickly than others.
Some medications are CYP2D6 inhibitors and reduce or even completely block the conversion of codeine to morphine. The most well-known of these are two of the selective serotonin reuptake inhibitors, paroxetine (Paxil) and fluoxetine (Prozac) as well as the antihistamine diphenhydramine and the antidepressant, bupropion (Wellbutrin, also known as Zyban). Other drugs, such as rifampicin and dexamethasone, induce CYP450 isozymes and thus increase the conversion rate.
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