Lets talk about GABA (as a supplement) again

[Ham-milton]

it's not. It can be enjoyable for some people. You either love it or you hate it.

 

[BrokenPages]

Consumed 900 mg...this sucks...I guess I need to either up it but this is my frist time taking it and this makes me not want to even try it again. Its making me tired, there is no uplift in anyway shape or form, yah there is a not caring feeling but big deal....just confused, though it would be different. I don't see how you can enjoy this, other then what it says. But again... everyone is different

 

[Jamshyd]

Don't try to get high on Gabapentin. It might give you a buzz the fist few times if you take huge doses, but then that goes away. Its not worth wasting your tolerance with chasing a buzz. Gabapentin is great medicine, just not a recreational drug.

 

[Yopreacher]

How about intranasal GABA? There is at least one study on mice were intranasally administred GABA seemed to enter CNS without crossing the BBB.

 

[pofacedhoe]

Ok, I was scanning the forums for opinions and studies, and this seems to be about as inconclusive as the Loperamide question.

So lets open this can of worms again. What say ye, o wise ones?

I never tried this due to the prominent idea that GABA is innefective due to not crossing the BBB. Then I find people claiming that it can do that via active transport. In any case, I'll probably pick a bottle of this (since its cheap) tomorrow and give my input. Till then, let me know what you think.

it is well buff but after about half an hour the body puts a limit on things and it doesn't get stronger. i thought at first it was like xanax but no it gets to the ten mintue point were normally the xanax destroys you, but this stuff you can stay awake or sleep. if you mix it with even one drink of alcohol though prepare for about 14 hours of sleep.

also if you do bezo's it enhances the effects

it is a usefull tool for controlling manic rage at work and for getting some sleep-it is Not a benzo so dont expect fireworks

i love the way that people on this site (not the person i quoted here) often theorise and get adament about the effects of things they have never even tried. i tried it and yes it has AN effect. an example of pretending to know without experience is the mephedrone fiasco. when you try a drug you can compare it to other known drugs you have experienced which is as good an indicator as a SAR guess.

love to all

 

[Hammilton]

i love the way that people on this site often theorise and get adament about the effects of things they have never even tried. i tried it and yes it has AN effect.

That's because we're smart enough to look at the studies that show it has no effect. If you knew anything at all about research methodology, you'd know exactly why saying that it has an effect is meaningless. I tend to believe it when people take something and describe rather strong effects, but even then, it doesn't really mean anything. When people take something and mix it with other drugs, I find it especially dubious. Everyone should know by know the huge variability subjective effects both between and even, within individuals. Drugs are hugely affected by expectation.

an example of pretending to know without experience is the mephedrone fiasco. when you try a drug you can compare it to other known drugs you have experienced which is as good an indicator as a SAR guess.

The mephedrone fiasco? There's nothing like pointlessly exagerating.

Sorry, but that's much less useful than a "SAR guess." A SAR study looks at a wide range of compounds binding to the same receptor(s) objectively and produces generalizable results.

It's nowhere near perfect, but this is much more effective than taking the drug and guessing what receptors it's binding to, what it's doing.

Wow... comments especially hilarious in this light:

it can fuck with your heart like all stimulants and although unproven its highly likely that is causes 5ht2b stimulation and the problems associated with that (wiki). using it rarely, solves this danger as mdma also has affinity for that receptor (people just dont use mdma that often (if they have a brain)) and we havent seen a huge amount of pulmonary blah from all those ravers years ago.

 

[ebola?]

[QUOTE='shyd]So taking gaba, like taking Serotonin WILL have an effect on those (with the latter, vascular issues, I believe).[/QUOTE]

IIRC, the vast majority of 5ht receptors are in the GI tract.

It can be enjoyable for some people. You either love it or you hate it.

And some consider it "okay".

 

[pofacedhoe]

That's because we're smart enough to look at the studies that show it has no effect. If you knew anything at all about research methodology, you'd know exactly why saying that it has an effect is meaningless. I tend to believe it when people take something and describe rather strong effects, but even then, it doesn't really mean anything. When people take something and mix it with other drugs, I find it especially dubious. Everyone should know by know the huge variability subjective effects both between and even, within individuals. Drugs are hugely affected by expectation.



The mephedrone fiasco? There's nothing like pointlessly exagerating.

Sorry, but that's much less useful than a "SAR guess." A SAR study looks at a wide range of compounds binding to the same receptor(s) objectively and produces generalizable results.

It's nowhere near perfect, but this is much more effective than taking the drug and guessing what receptors it's binding to, what it's doing.

Wow... comments especially hilarious in this light:

you cannot guess which receptors a drug binds to (although you have) but you can tell if a neurotransmitter is being affected if you have been on a drug specifically affecting that neurotransmitter (citalopram anyone-proven highly selective for serotonin by pure blessed science), so although SAR guessing (which is what it is- an educated guess, like the expectations of atoms behaviour in the periodic table, due to patterns seen, that have yet to be produced for real) in a lab is a nice and often accurate tool, placing all your faith in it shows a lack of appreciation for experience and the chance you could be wrong (or mildly to the left of the centre of correction), and surely experience is a case study which you have correctly arrgued before is of validity. One important thing to remember is the idiosyncratic nature of humans and physical reactions which have shown time and again that peoples bodies react differently for a huge variety of reasons...

what is hilarious is your constant ass-umption that you are correct

also i just had a coffee but as i expected it to improve my mood and waken me up i'm sure it was all placebo. now to smoke some crack in my garrage-lets see if expectation alone can produce a bellringer (ironic as this is almost true and proven-sensitisation, addiction and triggers- even though with this analogy and sarcasm it would seem i am suggesting other wise).

oh and dont forget to take my complete explanation apart into individual sentences so that it can be seen out of context, distorted and misinterpreted so you can feel a small sense of win a couple of times. enjoy.

also i dont think its that ridiculous to suggest that occasional 5ht2b stimulation-lsd, mdma, blah blah- will cause a problem. the main issue with this recepetor is cronic stimulation of 5ht2b leading to uncontrolled cell division, not occasional use causeing sixties highpies to drop like flies swatted by the tale of a mad invisble fool

ding ding i'm free

 

[LabRatNW]

1/4 kilo rectally?

This made me laugh.

 

[pofacedhoe]

This made me laugh.

i'm sure i've done turds that size. have you seen the south park were turds are measured in kourics? bono turns out to be a really old poo

 

[Doctor War]

^GABA receptors are very abundnt, I believe they are the most abundant mamallian receptors throughout the body (of mammals hehehehehehe). I think it only has peripheral effect; at least of a noticeable sort. I no longer take it, i ffeel like the breathing issue reminds me slightly of opiate intoxication without any of the good side....It also makes me feel physically 'panicky'.

Now if I could turn it into GHB I would be happy.

Without getting into synthesis discussion; let me just say that it's very doable, and a simple reaction requiring only basic lab competence on the order of a high-school chem graduate or a first year uni student.

 

[wreckhead]

In conclusion, taking GABA as a supplement is almost entirely pointless and possibly dangerous. GABA analogues and related GABAergics are much more interesting.

Without getting into synthesis discussion; let me just say that it's very doable, and a simple reaction requiring only basic lab competence on the order of a high-school chem graduate or a first year uni student.

I've been wondering about that, considering how similar the molecules are. Just need to lose the amine and gain alcohol...

 

[pofacedhoe]

In conclusion, taking GABA as a supplement is almost entirely pointless and possibly dangerous. GABA analogues and related GABAergics are much more interesting.



I've been wondering about that, considering how similar the molecules are. Just need to lose the amine and gain alcohol...

maybe so but it has really good effect for taking the tension out of your muscles
without making them so slack that breakfast falls out your ass in time for brunch and you end up dining out on the same meal more than once

a possible valium con sequence

 

[Alchemist²³]

There are some interesting studys which indicate that GABA definitely has effects at low doses:

Psychological stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA) in humans: assessment of stress using heart rate variability and salivary chromogranin A.

We studied the psychological stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA), on stress induced by an arithmetic task using changes of heart rate variability (HRV) and salivary chromogranin A (CgA). Subjects ingested 10 g chocolate enriched with 28 mg GABA (GABA chocolate); 15 min after the ingestion, subjects were assigned an arithmetic task for 15 min. After the task, an electrocardiogram was recorded and saliva samples were collected. HRV was determined from the electrocardiogram, and the activity of the autonomic nervous system was estimated through HRV. The CgA concentration of all saliva samples, an index for acute psychological stress, was measured. From HRV, those taking GABA chocolate made a quick recovery to the normal state from the stressful state. The CgA value after the task in those taking GABA chocolate did not increased in comparison with that before ingestion. From these results, GABA chocolate was considered to have a psychological stress-reducing effect.

http://www.ncbi.nlm.nih.gov/pubmed/19462324

Could the chocolate somehow help with with absorption becouse of the fat and lecithin?

Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.

γ-Aminobutyric acid (GABA) is a kind of amino acid contained in green tea leaves and other foods. Several reports have shown that GABA might affect brain protein synthesis, improve many brain functions such as memory and study capability, lower the blood pressure of spontaneously hypertensive rats, and may also have a relaxation effect in humans. However, the evidence for its mood-improving function is still not sufficient. In this study, we investigated how the oral intake of GABA influences human adults psychologically and physiologically under a condition of mental stress. Sixty-three adults (28 males, 35 females) participated in a randomized, single blind, placebo-controlled, crossover-designed study over two experiment days. Capsules containing 100 mg of GABA or dextrin as a placebo were used as test samples. The results showed that EEG activities including alpha band and beta band brain waves decreased depending on the mental stress task loads, and the condition of 30 min after GABA intake diminished this decrease compared with the placebo condition. That is to say, GABA might have alleviated the stress induced by the mental tasks. This effect also corresponded with the results of the POMS scores.

http://www.ncbi.nlm.nih.gov/pubmed/22203366

[h=1]Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.[/h] The effect of orally administrated gamma-aminobutyric acid (GABA) on relaxation and immunity during stress has been investigated in humans. Two studies were conducted. The first evaluated the effect of GABA intake by 13 subjects on their brain waves. Electroencephalograms (EEG) were obtained after 3 tests on each volunteer as follows: intake only water, GABA, or L-theanine. After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to see the role of relaxant and anxiolytic effects of GABA intake on immunity in stressed volunteers. Eight acrophobic subjects were divided into 2 groups (placebo and GABA). All subjects were crossing a suspended bridge as a stressful stimulus. Immunoglobulin A (IgA) levels in their saliva were monitored during bridge crossing. Placebo group showed marked decrease of their IgA levels, while GABA group showed significantly higher levels. In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.
http://www.ncbi.nlm.nih.gov/pubmed/16971751

 

[Jesusgreen]

Interesting studies, since this was bumped I'll post my own point. I can't really speak of the science but I can give my own experiences with GABA. I've found at 1.5-2g oral doses I experience some tingling sensations and sleep seems easier, but these effects are so mild it could be placebo. However what really did interest me is 0.5g and smaller doses were enough to nearly double the efficacy of alcohol and benzodiazepines for me. 0.5g GABA and 1.5 beers was enough to get me drunk with an average tolerance to alcohol (in fact by the time I was only half way through my first beer I was asked how much I'd already been drinking as people thought I was drunk), and 0.5mg Etizolam + 0.5g GABA felt stronger than 1.5mg Etizolam.

I never got any effects other than the tingling/it possibly being a bit easier to get to sleep from it on its own though, only in such combinations.

 

[Solipsis]

Yeah I've had those effect JG, flushing and an effect on my breathing reminding me of what a full dose of GHB can do... only all noticeable effects are brief and transient. Interesting but it weirds me out.
I don't recommend it, though it couldn't hurt to try it especially at typically low pricing.
But I doubt I would add GABA in the mix with GABAergics just like I wouldn't add beta-PEA in the mix with stimulants, empathogens or psychedelic PEAs.

Picamilon is so much better though, the next best thing theoretically since it is also GABA but linked to niacin (vit B3) which allows it to pass the BBB. And indeed it is also nice in practice, dose-dependent it can also be stimulating in that mild nootropic way. For me it's effective somewhat like phenibut is.

 

[Alchemist²³]

If you don´t like the cold-warm flushing effect the best way is to take GABA with food, if I take it with or after a medium to big meal it feels much better! I get the best effects at 100-500mg. I tried mixing it with Lecithin to enhance absorption (I read somewhere about liposome-encapsulated gaba which crosses bbb and hoped that just mixing it with lecithin could offer similar effects), I´m not sure if it had different effects than usual as I took phenibut, tramadol and synth. cannabinoids along with it, but I think I was much more tired the times I took the lecithin-mix.

I had a protein-oat-shake with about 300mg Gaba an hour ago and it gave me a really nice warm feeling an no cold flushes. Another positive thing I noticed is that I can get some of the opioid-tingling back if I take it after a good dose of Tramadol, if I get the right dose and no flush)