Legal Alternative to Replace Ecstasy

frizzantik - I would think/hope that members would get more info prior to consumption. It IS annoying and suspicious that they give no information about what the substance actually is publicly, though.

Thoughts - if it's an analogue, it will be illegal in the US and in many other countries, as we have laws automatically banning all new analogues of controlled substances. If it's a new chemical that's somewhat similar to MDMA, it would probably just get banned shortly after release / mainstream adoption (MDMA itself was legal for a little while; the concept of inventing new drugs is not new, but the gov't just bans the new ones too). The third possibility is that it's some new combination / alteration of the current crop of 'legal alternatives,' none of which, from what I've heard, come anywhere near true MDMA.
 
Since when does methylone cause serotonin release? I thought it was a mild serotonin reuptake inhibitor and mimicked MDMA in effect on dopamine and norepinephrine only?
 
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I got that information from here (scroll to near the end). If I'm wrong, I apologise :)

Solistus: did you read the whole thread? Your questions are answered about halfway down page 2 (look especially for Starboy's posts, and the links I posted, including the one in this post) :)
 
i'm with coolio. my impression from taking the stuff is that the effects on serotonin are limited.

from the wikipedia entry: In vitro, methylone is threefold less potent than MDMA at inhibiting platelet serotonin accumulation and as potent as MDMA in its inhibiting effects on the dopamine and noradrenaline transporter
 
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that he was committed to developing safer, legal alternatives to prevent further drug-related deaths.
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HOW ABOUT: LOBBYING FOR AND OTHERWISE SUPPORTING THOSE WHO FIGHT THE WAR ON IDIOCY, PROPAGHANDA, AND IRRATIONAL, CHILDLIKE FEAR??? That will do more to prevent drug-related deaths than anything you could possibly imagine.


THIS MESSAGE SPONSORED BY A PEOPLE FOR A COGNITION FREE AMERICA
 
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Bro, he's already been doing that sort of thing for many, many years :)

Tathra: interesting, thanks for the correction. Coolio, I apologise. I'm surprised that my source was wrong, he's usually pretty knowledgeable about this sort of thing.
 
I assure you, methylone is very nice. Have tried.
Was in a cap (pure), unsure of dosage, but would have definitely been in the higher ranges (given by friend).

MASSIVE, truly massive euphoria. Was my first MDxx experience. I didn't feel much of a stimulation effect. But, my god. The empathogenic effects... the sight of the trees, friends's smiling faces, the sky filled with twinkling stars.. filled my eyes with tears of happiness, hehe, so much love it was almost overwhelming. MDMA hasn't been able to match this yet (have tried 4 times total, over 6 months) - I prefer the feeling of methylone - it's just feels better.
Not much of a comedown.
 
Edit - no posting of sources, legal or not - Skyline
 
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rainz3d said:
Ease=Methylone
source:
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Is that an advertisement? How crappy! It's pretty well established thta EASEtm contained methylone, but we never sold any to that retail outlet, or is this a keyword marketing strategy to sell bzp?

Perhaps you should talk nicely to the good people at bluelight about rates for advertising or at least read the rules before spamming out crap like this.
 
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Possibly meant "source" as in "source of information" - taken from that site "We also provide safe legal alternatives to methamphetamine speed, LSD, XTC ecstasy MDMA, methylone (ease) and other harmful and addictive drugs. "

FWIW :)

I think that the name of the site is going to be edited out though, under the no sources rule.
 
Sim0n said:
Well, MDMA causes release of dopamine, serotonin, and noradrenaline, and that all of these, especially dopamine, are thought to be neurotoxic. Methylone causes release of serotonin alone. Not dopamine or noradrenaline.

So methylone is, at least on the face of it, safer.
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Wherever did you come up with that information? Shulgin and friends did a study about 8 years ago which shows the opposite. Methylone is about equally potent to MDMA at dopamine and norepinephren receptors, and 1/3 as potent at 5-HT receptors.

Methcathinone, the benzylic ketone analog of methamphetamine (MA), and methylone, the benzylic ketone analog of 3,4-methylenedioxymethamphetamine (MDMA), were synthesized and tested for their abilities to inhibit monoamine uptake in vitro. Methcathinone and methylone were threefold less potent than MA or MDMA at inhibiting [3H]5-HT uptake into human platelets, with IC50's of 31.4 ± 7.3 mM and 5.8 ± 0.7 mM, respectively. In C6 glial cells stably expressing the rat dopamine transporter, methcathinone and methylone were similar in potency to MA and MDMA, with IC50's for [3H]DA uptake of 0.36 ± 0.06 mM and 0.82 ± 0.17 mM, respectively. Methcathinone and methylone were also similar in potency to MA and MDMA in C6 cells expressing the human norepinephrine transporter, with IC50's for [3H]NE accumulation of 0.51 ± 0.10 mM and 1.2 ± 0.1 mM, respectively. The benzylic ketone moiety of methcathinone and methylone had a large (tenfold) negative impact on the abilities of these drugs to inhibit the vesicular monoamine transporter (VMAT2) compared to MA and MDMA. In VMAT2-containing bovine chromaffin granules, the IC50's for [3H]5-HT uptake were 103 ± 15 mM for methcathinone and 125 ± 16 mM for methylone. These results indicate that methcathinone and methylone are potent and selective inhibitors of plasma membrane catecholamine reuptake transporters, with more modest effects at the serotonin reuptake transporter. These drugs are essentially inactive at the vesicular monoamine transporter.
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http://www.mdma.net/methylone/catechol.html
 
Sorry, I missed that - I should have made certain to read the entire thread before responding.
 
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