i want to start lamotrigine against depression but i am worried about something i read in a psychopharmacology advisory. the author writes that sertraline must not be combined with lamotrigine because this will raise the risk of steve johnson's syndrome. his explanation is that sertraline somehow interferes with lamotrigine being metabolized by glucuronic acid conjugation. When both drugs are mixed lamotrigine uses other metabolic pathways and this creates toxic byproducts.
What worries me about this is that many people I know are on this very combination of drugs (sertraline + lamotrigine).
Either their doctors do not know about this interaction or they think it's not important. But it also talks about this at drugs.com
http://www.drugs.com/ppa/lamotrigine.html
What worries me especially is how shall I know if any other prescription drug might not have the same effects as sertraline when taken together with lamotrigine?
Is there any way to tell if an antidepressant or a drug in general will interfere with the glucuronic acid conjugation of lamotrigine? I mean if sertraline interferes with it
then who knows how many other drugs do the same then this basically means whenever you have to take another prescription drug you have to worry that it could do the
same as sertraline. 8(
I am currently taking a new antidepressant (vortioxetine) and from all SSRI I have taken so far it's the best but my pdoc told me that since vortioxetine is so new and we don't know that much about it I should get off it before going on lamotrigine which is really stupid cause vortioxetine wasn't that bad.
What worries me about this is that many people I know are on this very combination of drugs (sertraline + lamotrigine).
Either their doctors do not know about this interaction or they think it's not important. But it also talks about this at drugs.com
http://www.drugs.com/ppa/lamotrigine.html
What worries me especially is how shall I know if any other prescription drug might not have the same effects as sertraline when taken together with lamotrigine?
Is there any way to tell if an antidepressant or a drug in general will interfere with the glucuronic acid conjugation of lamotrigine? I mean if sertraline interferes with it
then who knows how many other drugs do the same then this basically means whenever you have to take another prescription drug you have to worry that it could do the
same as sertraline. 8(
I am currently taking a new antidepressant (vortioxetine) and from all SSRI I have taken so far it's the best but my pdoc told me that since vortioxetine is so new and we don't know that much about it I should get off it before going on lamotrigine which is really stupid cause vortioxetine wasn't that bad.
