• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Lacosamide: Abuse Potential

flacky said:
Mods: Can you post libbyave's IP info? I bet a lookup will go back to some interesting results.
Click to expand...

no

IP's are private.
who cares if drug company stooges write stuff here,

or epileptics/ epileptologists (sic!!)

RC stooges post thinly veiled stuff here and in trip reports.

I don't really see why the scheduling was worth challenging? hamm do you know something that we don't?
 
flacky said:
Libbyave, just because you have a problem, that doesn't mean that everyone else should suffer in the long-term for your short-term relief. Seriously, what kind of sadist are you?
Click to expand...

Erm, I think you're starting to get a bit carried away here. :\


To be fair, both Libbyave and Hamilton have a point, who is correct is mearly a matter of opinion and situation.
 
I don't really see why the scheduling was worth challenging? hamm do you know something that we don't?
Click to expand...

Yeah, though I don't want to go into it here. I can elsewhere, though.
 
Ok against my better judgement im replying.

First off - im a person with epilepsy - epileptic went the way of spastic and retarded and is generlaly considered to be offensive.

Second i know lacosamide is not a panacea - ive been through many drugs, the ones that worked best for me worked on the sodium channels but had unacceptabel side effects - i have very high hopes for lacosamide because of its method of action - which may well be dashed but there you go.

Yes I did come across this forum while browsing on progress of the drug (which i do every day)- its not hard - i followed the dea public comments posted on line - i noted the wikipedia alteration under lacosamide and hey presto a few more searches and im here - i guess that makes me a reasonably intelligent "epileptic". I think my google search was "Lacosamide public hearing". However as you say cant prove either way

Finally epileptologists doesnt require "(sic!!)" its an accepted term for an epilepsy specialist and is spelt correctly
 
First off - im a person with epilepsy - epileptic went the way of spastic and retarded and is generlaly considered to be offensive.
Click to expand...

I can't possibly abide by that. PC has already gone too far, this is just insane. So, people who have diabetes can't be called diabetics, people with schizophrenia can't be called schizophrenics, people who have problems with addictions are no longer addicts, those who drink uncontrollably are no longer alcoholics.

I'm sure I could extend the "people with blank" to blank-ics pattern much longer, but I'm getting bored.

Depakote is nearly free of side effects, works on sodium channels. Even a 2500mg dose doesn't produce noticable effects in me, and even months at a time at 1500 I still don't notice anything.

The biggest problem is that it's been around seemingly forever and there's no generic.

I think it goes generic this fall, actually.
 
Sadly epilepsy carries enormous stigma in a way that diabetes does not. On the PC front - infact i dont care.

Hammilton - Dapakote - your very lucky and relatively unusual - its generally considered to be an instant old age drug - significant weight gain, hand tremors, big cognitive hit - been there done that - but if you do well on it then thats good - This is the fundamental issue with aeds theres no way of knowing how individuals will react - I took carbamazepine for 20 years with no side effects then i couldnt tolerate it in even tiny doses - since then its been the medigo-round looking for a good fit (no pun intended)
 
Sadly epilepsy carries enormous stigma in a way that diabetes does not. On the PC front - infact i dont care.
Click to expand...

What? I don't know where you're from, but I've never seen any sort of stigma relating to epilepsy.

Diabetics are fat slobs
Schizophrenics are dangerous lunatics
alcoholics wife-beating bums
addicts child-corrupting thieves

Epileptics know how to get down.

I should put that on a T-Shirt.
 
^ let people speak.

I have learnt something today, epileptology really exists, and there are epileptologists, rather than being called neurologists.

perhaps there is also overnarrowspecialism and overnarrowspecialists.

I don't think epilepsy is particularly stigmatised, and a person with epilepsy is an epileptic.

call fig a fig and a spade a spade
 
perhaps there is also overnarrowspecialism and overnarrowspecialists.
Click to expand...

They're held in the highest esteem.

Frankly, to have a career based on treating one illness must be especially dull, but to have enough patients to do so, you must be pretty good or at least known.

Epilepsy is interesting, fine, but the treatment isn't especially interesting.
 
perhaps there is also overnarrowspecialism and overnarrowspecialists.
Click to expand...

They're held in the highest esteem.

Frankly, to have a career based on treating one illness must be especially dull, but to have enough patients to do so, you must be pretty good or at least known.

Epilepsy is interesting, fine, but the treatment isn't especially interesting.
 
"Lacosamide" reminds me of the type of drug that would be useful in the treatment of Alzheimers disease (AD).

Maybe I dont know what im talking about, but if it turned out to be useful for treating AD then it wouldnt surprise me.
 
why aren't dangerous, non-abusable drugs considered for scheduling? is the real motive behind scheduling effectively a control of pleasure potential, and not really a safety issue? i mean, why is not Revlamid scheduled?
 
Because the idea is to protect people from dangerous substances which they are LIKELY to abuse and go overboard with. Chemotherapy treatments arent going to be scheduled because there aint much danger in a someone abusing it...
 
Revlamid has little recreational potential, unlike thalidomide, which has the obvious issues.
 
I just wanted to note that in the year and a half since my last post (almost to the day, even), there does not seem to have been a single post about the recreational effects of lacosamide (Vimpat).

I don't think it has any, and the sole person I've talked to who is prescribed it confirms this, but that's hardly statistically meaningful. Perhaps it's no better than gabapentin- some people will like it but others report nothing. I doubt it's even as recreational as that, though.
 
Sounds to me about as recreational as lamotrigine, for instance, I.E bugger all.

I don't think sodium channel anything is going to be any fun, direct agonists, openers, blockers, nothing like that is anything but either a vicious poison, or in the case of some voltage-gated Na channel blockers, they are utterly without euphoric potential.

I take (unprescribed) lamotrigine, as my housemate has bipolar, and has a vast excess over and above what is needed both for use and as a backup, to deal with some myoclonus/akathisia unpleasantness, as well as to help me negate the presence of emotion.

Absolutely bugger all recreational potential in the stuff, never actually TRIED lacosamide, but if I had the chance, I would be curious enough to bioassay it, single-blind trial, and I bet I wouldn't be able to distinguish it from either lamotrigine or an inert control.

As for all the PC bollocks, 'person with...' as opposed to 'standard adjective', thats just fucking rediculous if you ask me, I was born with autism, so I am qualified in that sense to speak of that particular issue.

Regardless of the fact that I am very, very grateful I am autistic, that is what I am, and from observing those who are not, I would hate to be one of them. No offense intended to those not lucky enough to be aspie/autie.

I am a person, I have autism, I am a person WITH autism, but to me, that makes it sound like there is a person, and then there is autism, dissociated from the person, like something masking the real person inside of poor, ikkle autistic me, just begging to be cured and let out.

Know what, thats bollocks, political correct arse-leavings, sure I might have autism, but I just wish people who sit on boards, and make pronouncements of who may call whom what, and what words will or will not offend those who's particular political hot potato is the flavour of the day, and who choose to slobber political slogans as a profession, who are NT, or healthy, or are not epileptic, have down's syndrome etc, those who feel they have the right to, or that THEY need to on OUR behalf, to take one of their little books of mandates and slogans, bend right over, and shove it up their anus sideways edge on.

Doesn't matter who it is, or what it is.

A person who has epilepsy, is epileptic, one with diabetes, diabetic, me, 'having' autism, I am autistic.

It isn't usually the demographic groupings either which come up with the PC terms either, its the bastard penpushers who worm it into the way things are commonly spoken, by pressure first in official senses, between groups of officials, then it filters down like a virus and infects the general prevailing mindset.

Even autistic groups here and there, are taking on the 'person with autism' thing, although pretty rarely, and its usually not the groups run by us, for us, but those run with the intent of providing for us somehow, it filters down to the users, and the meme spreads.

Person with autism? (read 'person with epilepsy') yeech, no, fuckers, I am autie, or autistic if for formal interaction, an official formal term is the only one that can be accepted by another, I can accomodate that much, but all the pious fume-belching about making sure nobody offends us poor, ikkle defenseless people.......hows about if somebody offends me, I put my foot up their arse, if that is going to happen, it will be MY foot, not somebody else's foot on my behalf.

</soapbox>

Sorry, but I have a real problem with PC dipshits like that (using my own kind as the example, for reason of my being most familiar with that one, and that one involving me personally), creating issues, that create friction within communities, that otherwise could happily get on lining things up in rows, flapping, producing reclusive geniuses, aloof, remote, icy cold and oh so tasty females, or just straight up going out for drinks at the bar, sitting together, and not talking.

And hey, I didn't just post to tear the PC brigade a brand new septic wound in their anal sphincters, I did have my point about Na channel blockers, but then I just had to go back and read the PC comments didn't I....my mistake, shouldn't have looked at those should I now, if I knew, i wouldn't have, as it brings out the bastard in me=D
 
Last edited:
Hammilton said:
I can't possibly abide by that. PC has already gone too far, this is just insane. So, people who have diabetes can't be called diabetics, people with schizophrenia can't be called schizophrenics, people who have problems with addictions are no longer addicts, those who drink uncontrollably are no longer alcoholics.

I'm sure I could extend the "people with blank" to blank-ics pattern much longer, but I'm getting bored.

Depakote is nearly free of side effects, works on sodium channels. Even a 2500mg dose doesn't produce noticable effects in me, and even months at a time at 1500 I still don't notice anything.

The biggest problem is that it's been around seemingly forever and there's no generic.

I think it goes generic this fall, actually.
Click to expand...

^Yeah, there is a generic (at least in America, therefore probably everywhere). I can't possibly see any logic in having this drug further delayed for any reasons other than safety concerns, especially for something as trivial as a C-V restriction. As has been mentioned earlier, I really don't think many doctors are holding off writing for Lyrica based on its status.

Also, as mentioned earlier, not necessarily the best tolerated drug on earth, though decent for epilepsy. You must be pretty fortunate.
 
You must log in or register to reply here.
Top