l-amphetamine affects on PNS (Journal references)

[antec6]

l-amphetamine affects on SNS (Journal references)

I looked through extensive journal databases in hopes to find much on the affects of l-amphetamine on the SNS. I found one article.

Both d- and l-amphetamine were also compared for their pressor and tachycardic activity in pithed rats. The doses of amphetamine tested (0.1-10.0 mg/kg) were identical to those which produced changes in behavior. d-Amphetamine was approximately 5-fold more potent than l-amphetamine in evoking pressor responses and approximately 3-fold more potent in evoking tachycardic responses.

http://jpet.aspetjournals.org/cgi/content/abstract/193/1/149

I also found this.

In vitro inhibition of monoamine oxidase types A and B by d- and l-amphetamine

Miller, H.H., Clarke, D.E., (1978) Communications in Psychopharmacology 2 (4), pp. 319-326

Dept. Pharmacol., Coll. Pharm., Univ. Houston, Tex. 77004, United States


Abstract:

Experiments were made in vitro to investigate the monoamine oxidase (MAO) inhibitory properties of d- and l-amphetamine. The MAO inhibitory potency of d-amphetamine was found to be greatest in tissues showing high type A activity (heart > striatum = vas deferens > liver). Comparisons of d- and l-amphetamine on only the type B activity revealed that the enantiomers were essentially equipotent, yielding an IC50 of approximately 1.1 x 10-3 M. Both enantiomers were more potent at inhibiting type A MAO, with an approximate IC50 of 1.2 x 10-4 M for l-amphetamine and 2.8 x 10-5 M for the d-form. Thus, on type A MAO, d-amphetamine is over four fold more potent than l-amphetamine. These potency ratios remained closely similar regardless of the tissue studied. The data suggest that inhibition of type A MAO by d-amphetamine may be an important pharmacologic property of the drug in vivo. Furthermore, the individual characteristics of the A and B activities do not appear to differ radically across the various tissues studied.

I understand that rats/dogs and humans are different indeed but this is stating that the l-isomer is 4x less potent than the d-isomer in inhibiting MAO-A and 5x less potent in increasing blood pressure? l-isomer also appears to be 3x less potent in producing tachycardia.

Does anyone have any other document links that show evidence for pressor or cardiac responces due to the alpha-methyl PEA isomers. To me the above articles state the opposite of what is thrown around about the isomers.

Maybe l-meth is different than l-amph?

MAO-A inhibition is generally known to increase blood pressure and heart rate in the presence of stimulants which some may know by experience.

 

[Ham-milton]

ah... what's the "SNS"??

wasn't that an old console game system?

Edit- and yeah, you can't compare the l-isomer's of the two different compounds. L-ampehtamine is still a relatively powerful stimulant, whereas l-methamphetamine has almost no CNS activity, differs little from pseudophedrine in effect.

 

[indelibleface]

^^Sympathetic nervous system.

 

[antec6]

ah... what's the "SNS"??

wasn't that an old console game system?

Sorry I meant NNS, "Nintendo Nervous System."



SNS stimulation = heart, BP, pupil, etc... increases.

Do you have references to the potency of l-amph and l-meth on the DA, NA, and 5HT systems? Maybe compared to the D-isomers? I have some for amph isomers but not the n-methyl.

D and L were just as potent on the NA system. The D was more potent on the DA system than the L. No references for the 5HT was given. D-meth has more affect on the 5HT system than D-amph. D-Phenmetrazine has pretty much null affects on the 5HT system and low affects on the NA system but high affect on the DA system. Very similar to d-amph. I am surprised this has not been tested for narcolepsy and related sleep issues.

 

[Riemann Zeta]

Mmm, phenmetrazine. I think it would be a great ADD drug, perhaps with fewer side effects than even pure (d)-amphetamine. I don't really have any sides from dexamphetamine, but phenmetrazine has always appealed to me, as phendimetrazine is quite effective and enjoyable with little peripheral effects (since phendimetrazine is a completely inactive prodrug, I attribute its effects to the 30% of the dose metabolized to phenmetrazine).

 

[antec6]

Mmm, phenmetrazine. I think it would be a great ADD drug, perhaps with fewer side effects than even pure (d)-amphetamine. I don't really have any sides from dexamphetamine, but phenmetrazine has always appealed to me, as phendimetrazine is quite effective and enjoyable with little peripheral effects (since phendimetrazine is a completely inactive prodrug, I attribute its effects to the 30% of the dose metabolized to phenmetrazine).

I agree!