Kratom with Ropinirole or Pramipexole?

[Hammilton]

This is unlikely to be a common concern, but I'm hoping someone with more experience of the lit or from experience could comment on whether or not there was likely to be an interaction between kratom and pramipexole or ropinirole. I have severe RLS, and when I'm not on an opioid it gets even worse. I've switched to maintain on kratom because it's cheaper than Subs, but if the legislature bans kratom, I may end up back on Subs, I'm afraid. Anyway, in the mean time, I've been taking 2 doses a day each around 1 or 2. Unfortunately my RLS comes back on pretty strong by morning, it's noticeable by 8am and unbearable by 10am when I'm forced to get up. I work a late 2nd shift, so 10am is usually 6 hours of sleep. Today I tried taking another dose of kratom, but I really don't want to do that. Twice a day is enough to prevent withdrawal, and that's all I'm after.

Ham

 

[sekio]

There shouldn't be too much interaction, kratom does not have much in the way of dopaminergic acitivity.

 

[Hammilton]

Yeah, but with the weird adrenergic effects and what not, I was a bit leery.

It's sad that I'm not taking the really important meds because I'm taking kratom. But it's just so much cheaper than Subs. I just wish it had a similar half life. I figure I can always take L-Dopa with anything, and I don't know of anything that Carbidopa interacts with. I'd like to go back on Selegiline just to extend the duration and limit the neurotoxicity of the dopa but I'm not willing to mix Kratom and Selegiline yet.

 

[Lightning-Nl]

Well... Kratom decreases NMDA-induced current (by calcium channel blockade?) and therefore, likely, upregulates the monoamines by downregulating Glutaminergic activity. Maybe Kratom acts as an antagonist at mGlu Receptors? (this would explain how it decreases NMDA firing without actually blocking the receptor itself).

Either way, Kratom has a documented history of causing psychotic symptoms. I really doubt that adding a dopamine agonist (or any other drug that causes psychotic symptoms) on top of that would be a good idea...

 

[sekio]

Either way, Kratom has a documented history of causing psychotic symptoms.

I've never heard of kratom psychosis... mostly just the standard opioid dependence fodder. And the occasional yohimbine-like vomiting/anxiety.

Also, some minor kratom alkaloids are NMDA channel blockers. No idea on their prevalence in kratom or the actual relevance to its effects in man. It seems most likely that kratom is pretty much relegated to adrenergic and opioid effects, although some studies have indeed shown that there is a non-opioid painkilling component. I think it may be varietally dependent what alkaloids are present/prevalent.

 

[ebola?]

Well... Kratom decreases NMDA-induced current (by calcium channel blockade?) and therefore, likely, upregulates the monoamines by downregulating Glutaminergic activity.

This is not a well-established downstream effect of NMDA antagonists.

although some studies have indeed shown that there is a non-opioid painkilling component.

Honestly, I would look to central adrenergic activity to explain this.

ebola