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Ethnobotanicals Kratom psychedelic properties?

I believe THH is very weak as a REMI. It has affinity for the serotonin transporter, which means it can technically compete with serotonin, but it's not otherwise clear what it does there or anywhere else for that matter. If it does inhibit serotonin transport appreciably, this could potentiate DMT to a degree by preventing the transporter from removing DMT from the synapse.

A more interesting effect of THH may be to induce long-term upregulation of the transporter, which may lead to a few days reduced serotonin transmission activity follows by an upregulation of other serotonin subtypes (as they compensate for the reduced serotonin in the synapse). Presumably it could be used periodically, like maybe once per week to maintain this effect. In the long-term, this may have effects which are in many ways opposite that of SSRI drugs. Hence, I'm inclined to call THH an "anti-SSRI", even if the acute effects may block some serotonin uptake.
 
iom said:
I believe THH is very weak as a REMI. It has affinity for the serotonin transporter, which means it can technically compete with serotonin, but it's not otherwise clear what it does there or anywhere else for that matter. If it does inhibit serotonin transport appreciably, this could potentiate DMT to a degree by preventing the transporter from removing DMT from the synapse.

A more interesting effect of THH may be to induce long-term upregulation of the transporter, which may lead to a few days reduced serotonin transmission activity follows by an upregulation of other serotonin subtypes (as they compensate for the reduced serotonin in the synapse). Presumably it could be used periodically, like maybe once per week to maintain this effect. In the long-term, this may have effects which are in many ways opposite that of SSRI drugs. Hence, I'm inclined to call THH an "anti-SSRI", even if the acute effects may block some serotonin uptake.
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That's a very interesting take on this, I wouldn't doubt it could occur. I only ever took it acutely, and my experiments that involved solely THH were pretty sparse compared to those where I was combining it with harmaline, typically in a 2:1 handline:THH mixture. I believe than when trying to use it to potentiate DMT I'd pushed it over 100mg but the physical discomfort from that dose alone was disincentivizing for me to push it further, given the abundance of harmaline I had on hand.

THH and mushrooms had much less effect than THH with LSD for some reason.
 
Did 10+ years of daily kratom: not a single moment of what I'd call hallucination or other psychoactive experience. Don't I wish.
 
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