Kratom pharmacokinetics/pharmacodynamics

[Sertürner]

So the title is the question. Looking on information on how kratom works as a whole, not just mitragynine/7-hydroxymitraginine, although those are of course 2 main talking points; I'm trying to figure out how its other alkaloids affect kratoms effects, generally speaking. I would have brought this to OD but I really wanted some in depth info.

Many thanks,
Mr. Deeds

 

[Anonymous Dissident]

^^Seriously cool article, thanks for posting it!!

 

[Crowsonator2008]

Maybe this would interest you -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189718/

That was a book about it lol.

 

[sekio]

There was a recent paper suggesting that mitragynine functions somewhat like codeine, in that it is only weakly responsible for opioid effects as it is metabolized in the liver to a more potent mu-agonist (7-OH-mitragynine).

 

[Sertürner]

Damn I've been so busy I havent been able to really get back on this discussion that I started. I was particularly interested in corynoxine b and the compounds that stimulate adrenergic receptors. I will give it a second read through and come back.