Opioids Kratom Interactions/Half-life

[elstongunn39]

I have been considering using kratom for my ADD and depression instead of being on stims, since they have started to present some really problematic side effects. I know that kratom shouldn't be used with stimulants as it has a number of unknown compounds that probably interact with adrenergic receptors etc... But I don't know the half-lives of all of the compounds, so I'm wondering how many days I should leave between my kratom use and taking focalin.

 

[Slow_Mobius]

Unfortunately, no one knows the half lives of all the compounds. Mytragynine has biphasic elimination kinetics. It's eliminated relatively slowly for several hours and then extremely rapidly. If you waited a day, you would probably be pretty much clear of the mytragynine.

Kratom has some serotonergic properties that could be dangerous. I know some people including myself have mixed kratom and amphetamines without any problems at low doses, but that doesn't mean it's safe. I think it's best to space at least 24 h between using either drug, but if you're going to be using high doses, I would wait a few days.

 

[kleinerkiffer]

I read about a man having a seizure after combining kratom with modafinil, so kratom could lower the seizure threshold and as Slow_Mobius said, it could be serotonergic, so imo combining it with stimulants is a bad idea