S+ Ketamine shares some traits with MXE, but IME is much less visual, especially OEVs, but it is a more powerful anaesthetic and feels more sedating.
I would say also less Serotonine release/direct agonism.
It is also not an upper for me, I do not feel any surge in adrenaline, I think MXE might be slightly stimulant at least for some people, although it doesn't feel adrenergic to me.
Racemic Ketamine will impair your motor coordination much more than S+, and this makes it a very different compound.
K-Holes are more trippy and immersive for me compared to M-Holes, and it is possible (at least for me) to reach a point were while experiencing the K-Hole my personality changes and upon cessation of effects I wouldn't understand why I would think that stuff as it doesn't make sense at all to me, as in not like I wouldn't agree with those thoughts but rather failing to understand them or see an underlying logic.
Never happened with MXE.
Ketamine is way more likely to have you sit/lay down for the peak, unable to roll a spliff or take off your hoodie or even speak, although this might be actually good for you
sometimes, will prevent you from being able to act like a fool/create danger for self and/or others/wander off randomly leaving all your possessions behind etc... and maybe even redose, like it would be possible with MXE.
On the flip side one can get injured while trying to move, and even worse not realize it and make it worse/not seek medical assistance; also I saved or witnessed people being saved from choking in their vomit as they were lying on their back facing up totally unaware of what was happening to them.
For me the shorter duration of K is not a negative by the way, rather a positive attribute as if I hole for 30-40 min I will feel like I was tripping for ages and find myself satisfied, meaning I never once redosed after a K-Hole, but I find small doses moreish.
I also love how properly ground K comes on super fast from insufflation, like definitely feel it after 2 minutes, strong effects after 5, Hole before 10 have passed.
I see as how this might be unsettling for some, as it is a rather quick change in perception.
If you like light effects you can do that but it means doing small rails often, probably every hour or so. And this can get compulsive quickly, and doses will need to be increased or redosing more frequent as the session progresses as tolerance develops really fast with Ketamine. It is very annoying unless you are indoor in a safe place as you can imagine disappearing multiple times and walking around funny can get you noticed in a public setting that is not drug tolerant. And as your motor coordination gets worse and worse, dosing and preparing lines will become a very difficult and slow process, and I have seen people trying to snort a rail and move the straw like more than an inch over it and realizing they insufflated precisely nothing only after several seconds.
Ultimately, if a drug is worth trying can only be personal decision on your part, your fellow Bluelighters can only provide you with their experiences, suggestions and all sorts of info that you might need to make an informed decision and, in case the decision will be to go ahead and ingest a drug, to make sure that you are aware of how to avoid/minimize the associated dangers.
