Ketamine wikipedia NMDA affinity

[specialspack]

Seems wildly wrong:

http://en.wikipedia.org/wiki/Ketamine

The S(+) and R(-) stereoisomers bind with different affinities: Ki = 3200 and 1100 nM, respectively

Ref - Hirota, K; Lambert, DG (1996 Oct). "Ketamine: its mechanism(s) of action and unusual clinical uses". British journal of anaesthesia 77 (4): 441–4. http://www.ncbi.nlm.nih.gov/pubmed/19546251

I looked at this paper and it states the Ki values above without obvious reference or any experimental data. Given that S-ketamine is widely regarded by just about every other source as several times more potent in effects, and equally having an affinity for the NMDA receptor several times that of R-ketamine, this seems like a strange anomaly? Any reason why I'm wrong?

 

[pofacedhoe]

affinity and efficacy being different?

 

[skillet]

This one says differently, and is maybe more believable:

In agreement with earlier studies (S)-ketamine (Ki 0.3 microM) was found to possess a 5 times higher affinity for the NMDA receptor complex than (R)-ketamine (Ki 1.4 microM).

If they don't even reference that I'd assume it's just a (bad) mistake. Maybe they got it backwards? Or took the values from different sources.

 

[atrollappears]

Probably just a decimal error...
Those things were the bane of my middle school math skills. That and negatives.

 

[Hammilton]

Looks like a decimal error, that's all.

 

[Ektor]

3200nM looks like it was really 320nM, which is consistent with 0,3microM. 1100 is already consistent with 1,4microM, so:

S-ket: 320nM; 0,3uM
R-ket: 1100nM; 1,4uM

BOOM!