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Ketamine salts solubility

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Can someone help me come up with a chemical that would likely bind to opioid, GABA, Histamine (Antagonist), muscurinic (anticholinergic), NMDA, and possibly serotonin, dopamine, and norepinephrine? Maybe not all of them, but atleast the first three. Lol
 
Created a new YouTube channel and posted a little video of the molecule I just made that could possibly bind to opioid, GABA, Histamine, and cannabinoid receptors
 
The Holy Quadruplty said:
Can someone help me come up with a chemical that would likely bind to opioid, GABA, Histamine (Antagonist), muscurinic (anticholinergic), NMDA, and possibly serotonin, dopamine, and norepinephrine? Maybe not all of them, but atleast the first three. Lol
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Nevermind it looks like I found one already messing with alprazolams structure.
Created a new YouTube channel and posted a little video of the molecule I just made that could possibly bind to opioid, GABA, Histamine, and cannabinoid receptors. I need someone to name it for me though please, and thank you!
 
arrall said:
That one does absolutely nothing, are you just making random molecules here?

It needs to be SMILES, not 10th grade Chemistry notation where you have no clue as to what the arrangement of the molecule is.
Click to expand...
Created a new YouTube channel and posted a little video of the molecule I just made that could possibly bind to opioid, GABA, Histamine, and cannabinoid receptors
 
I’ve never heard from a substance that both binds to gaba and opioid receptors at the same time. You could try adding a ghb ester to an opioid I think that’s it. GABA and sigma agonism in one molecule seems doable though.
 
izo said:
I’ve never heard from a substance that both binds to gaba and opioid receptors at the same time. You could try adding a ghb ester to an opioid I think that’s it. GABA and sigma agonism in one molecule seems doable though.
Click to expand...
I ended up finding one pretty quickly messing with Alprazolams structure. I made this video for it on the new YouTube channel I just made. It also may bind to cannabinoid receptors as well, and a lot others. You should watch it!
 
The Holy Quadruplty said:
Created a new YouTube channel and posted a little video of the molecule I just made that could possibly bind to opioid, GABA, Histamine, and cannabinoid receptors
Click to expand...

Those interactions are really low confidence. It likely doesn't bind to those targets. You want the green bar like mostly full to believe that a molecule might possibly interact with a receptor.. Try putting a real drug and see the confidence levels produced there (Wikipedia usually has smiles codes on drug articles).
 
The Holy Quadruplty said:
I ended up finding one pretty quickly messing with Alprazolams structure. I made this video for it on the new YouTube channel I just made. It also may bind to cannabinoid receptors as well, and a lot others. You should watch it!
Click to expand...

You gotta look at how low those probabilities are. The odds of it binding to more than one or two of those receptors well enough to produce a significant effect are very slim. It could very well be inactive.
 
izo,

I too am beginning to wonder what my 3.0 mg Vraylar (cariprazine) is doing exactly.

However, I Don't Sell Drugs. I Just Give Them Away Freely. Y Mis Drogas Son LO MEJOR.
 
BTW I do not correct to insult, I correct so that everyone can improve their organic chemistry. It's my 'specialist subject' if you will. If my car stops working, my heating fails or indeed any of the million things that I have to face, I know nothing. This is my ONLY skill. If you ever need to ask, ask. If my fridge stops working, I would hope someone with that practical still would help me.

I would also add that it is no reflection if intelligence. Medicinal chemists are idiot savants.
 
Out of interest - do people look at existing reagents, understand WHY they are active and then modify.


ibb.co

eti hosted at ImgBB

Image eti hosted on ImgBB
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Etifoxine is quite similar to benzodiazepines but acts acts as a PAM at a different set of GABAA receptors compared to 1,4-benzodiazpeines which in turn bind to different sites to 1,5-benzidiazelpeines (e.g. clobazam).

The shape of the receptors used by benzos and relatives has been written up - people can check.

Etofoxine is unusual because the m-Cl is just about the ONLY active example but if used in a trial set with other GABAA PAMS, it does explain a lot.

It's possible to sketch all manner of stuff but it WOULD be nice for people to explain what receptors a compounds is designed to bind to AND how one would go about making a compound from commercially available precursors.

I mean, the -N-ethyl-4-methyl-4-phenyl-4H-benzo[d][1,3]oxazin-2-amine partly overlay the 1,5-benzidiazepinenes which partly overlay the 1,4-benzdodiazpeines.

If someone was to find the QSAR of the -N-ethyl-4-methyl-4-phenyl-4H-benzo[d][1,3]oxazin-2-amine, that would be very valuable.

As it is, people are posting with no synthetic pathway. I can dream any compound you name, but if it has to be made, one needs a route.
 
I have a stack of designs..... designed.... but this isn't the place.... OK ome.


ibb.co

md hosted at ImgBB

Image md hosted on ImgBB
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Just like MDMA but more potent by dose. The cyclobutyl is just space-filling and nothing more. LogP MDMA 1.66, analogue (MDCMA) 3.16 (because the 3 extra methylenes in the cyclobutyl make it more fat soluble) so 125 MDMA = 85mg CB-MDMA.

Kind of surprised that it didn't turn up.... suggesting that it's 'cooks' making MDMA. Do not get mw wrong, I have seen VERY pure MDMA made in Dutch labs but this is good because 80mg MDCMA ≉ 125mg MDMA.

This trick works with MANY PEAS but it's so synthetically complex, nobody bothers. BUT U think it is important that people understand the chemistry. Likewise. swapping the MD ring with an MX ring is about 25% more potent. IMPORTANY - the S is meta to the side-chain. If you place it para, it produces an MAOI which kills people!
 
I'd rather be an idiot savant who regularly hits pharmacological home runs like I do here than a normal person who goes to some dead end job, watches TV, and then goes to sleep. Logic has much less to do with drug design and discovery than intuition, rigorous organic chemistry instruction, extensive and rigorous Kekule structure memorization, human metabolism, and as much experience taking carefully measured, accurately identified drug substances as possible. Also, PiHKAL and TiHKAL by Alexander and Ann Shulgin is required reading. Uncle Fester's Secrets Of Methampbetamine Manufacture is quite bad. Strike's Total Synthesis II is better, but not outstanding--particularly now that Sassafras oil is completely restricted. Anyway, my IQ last time I took a standardized test was 141. 140 is genius, so I had a point to spare. In high school, I made a 750 our of 800 Verbal and 800 out of 800 in Math. The most recent schooling that I had involved getting a certificate in Medical & Drug Development from MIT. Also, right now I am on N-ethylamphetamine and 4-methoxy-beta-methoxymethamphetamine. So, yeh, I Rock. :)
 
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