Ketamine salts solubility

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ibb.co

I even came up with a name....

 

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I Don't Want Your Love!!

 

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I listen to that song on Loop for hours on end. If I could only ever listen to one song, this would be it.

 

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FLOTSAM
1-phenyl-2-methylamino-3,3,3-trifluoropropane

JETSAM
1-(4-methoxyphenyl)-2-methylamino-3,3,3-trifluoropropane

INNIE
1-(2,4,6-trioxo-3,5-diazacyclohexyl)-2-aminopropane

AUDI
1-(2-aminopropyl)-2,4,6-trioxo-3,5-diaza-3,5-dimethylcyclohexane

ANTI-MANIC
5-(1methylpiperazin-4-yl)-1,3-diazaindan

 

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EDWARD
1-(piperazin-1-yl)-1-carbomethoxy-1-(4-methylphenyl)methane

JONATHAN
N-(2-phenyl-1-methylethyl)-1-(piperidine-4-yl)-1-carbomethoxy-1-(4-methylphenyl)oxymethane

 

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What is Dresden? What is fluff? What is molecule?
Mark

 

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Dresden is one of my old usernames. Fluff was a kind of high quality LSD. A molecule is a collection of atoms attached to each other via overlap of orbital electrons.

FROSTY_FLURRY
4-ethylamino-1,1-diphenyl-2-oxapentane

TASTY_WORLD
4-methylamino-1,1-diphenyl-2-oxa-3-oxopentane

ICEY-ICE
2-methylamino-2-carbophenoxyethane

OCKHAM'S_RAZOR
2-amino-2-carbophenoxyethane

NIKKI
2-ethylamino-2-carbophenoxyethane

Danke!

OP8
1-(3-hydroxyphenyl)-1-oxa-2-oxo-3-methyl-4-dimethylaminobutane

Et tu, OP?

 

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JUICY_FRUIT
1-hydroxy-3-carboethoxypropane;
HO-CH2CH2CH2-(C=O)-O-CH2CH3

liquid inebriant

LOGICAL_PROGRESSION
1-phenyl-1-oxa-3-aminobutane

HERCULES
1-phenyl-1-oxa-3-(methylamino)butane

 

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What is Dresden? What is fluff? What is molecule?
Mark

Oh, don't bother. Many of the compounds on this thread are impossible to make, many more are in practice impossible to make and about 98% of what is left would be toxic or inactive. I guess either amphetamine addicts or dick-sizers are posting scaffolds.

If you REALLY want to know what works, Google Patents & various online databases will show you scaffolds and related patents and papers.

I don't think drug design is that complex, but you need to know some basic stuff like Lipinski's Rules of 5 - their are online calculators and if a compound violated a rule, it's almost certainly inactive. As a test, just try inputting some of the stuff posted here. It will instantly discard them. RO5 isn't a methodology of a design, but a really useful way of checking the 'druglikeness' of a compound.

https://pubchem.ncbi.nlm.nih.gov

Just enter the SMILES of a structure in the link above and you will quickly see how MOST of the compounds on this thread violate a rule or are already known... and you do not get to name a compound someone else found.

Of course, if you do find something with the appropriate RO5 that is novel and facile, people WILL tell you. But just drawing random stuff will not work except under the 'million monkeys with a million typewriters' discum.

 

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HERA_SHE_RA
1-phenyl-1-oxa-3-(ethylamino)butane

 

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Novel? There Is Nothing New Under The Sun.
Facile? That Is A Relatively Relative Term.
Arguing? Not My Thing, But I Still L.O.V.E You!

I Get My Rocks Off Mentally By Doing This, You Dig? Look At It As Post-Y2K Nuclear Conflagration Modern Art. That's Pretty Much All What A Lot Of It Is.

 

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HONEYSUCKLE
6-acetyl-1,1,2,4,4,7-hexamethyltetralin

Sweetest Smell I've Found Yet!

Simple-ist Inspiration:

NUT_SACK
1-(6-acetyl-1,1,4,4,7-pentamethyltetralin-2-yl)-2-aminoethane

HEDGING_MY_BET
1-(6-acetyl-1,1,4,4,7-pentamethyltetralin-2-yl)-2-aminopropane

THE_LONG_SHOT
N-allyl-1-(6-acetyl-1,1,4,4,7-pentamethyltetralin-2-yl)-2-amino-1-methoxypropane

THE_MONEY_SHOT
1-(4-acetyl-3-methylphenyl)-2-aminopropane

EVEN_FURTHER_OUT
4-oxa-2-amino-6-acetyl-1,3,3,7-tetramethyltetralin

 

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BEAVIS
1-(3,4,5-trimethoxyphenyl)-1-(4-piperidinyl)methane

BUTT_HEAD
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-(4-piperidinyl)methane

DARIA
1-(3,4-methylenedioxyphenyl)-1-(4-piperidinyl)methane

LIL_BOBBY
1-phenyl-1-(4-piperidinyl)methane

You Know, Lil Bobby's A Genius.

 

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Needs more monkeys...

 

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Join Us! Hammilton Did. And Now He Holds The Patent For Over 200 Tryptamines.

"Excuse Me, I Am A Monkey."--Aromaticity (me) @ The HIve, last century.

 

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I note that JSMOL is an open-source 3D viewer for organic chemicals. Given that it's written in Java, is it possible to add to Bluelight as viewing in 3D is of great value - especially if one is able to calculate minimum-energy conformation and overly 2 or more scaffolds.

I've also noted that https://app.syntelly.com/smiles2iupac is another online resource that converts a SMILES string into IUPAC naming.

If the 2 packages above could be included within BL it would have the potential to add a lot of new data while reducing the size of the database.

 

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BEN
1-(4-acetylphenyl)-2-methylaminopropane

BETH
1-(4-acetylphenyl)-2-ethylaminopropane

Everybody's Looking For Something.

 

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SWEET_CAROLINE
1-(4-acetylindole-3-yl)-2-dimethylaminoethane

SASHA_ALEXANDER_SHULGIN
1-(5-acetylindole-3-yl)-2-dimethylaminoethane

Sassy!

SAINT_PETER_SCHMID
1-(4-acetylphenyl)-2-aminopropane

Meine brudder. It might dimerize a bit. Shouldn't be too bad, though.

 

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Well it's the promethazine (antihistamine) molecule with a a 2-ethyl-2,3-dihydro-1H-isoindole moiety stuck to the 3 position.

I guess it's best to do is:

1- go to Wikipedia page on promethazine
2- copy the SMILES string of promethazine from the Wiki page
3- go to the Pubchem site
4- Paste in the promethazine SMILES and look at 'substructures'

That should only take a minute to do and maybe 10 more to find the compound if it's been made.

That way you will be able to see how people have added to the promethazine scaffold and what the results were. Pubmed is an awesome free resource.

 

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MARY ANN
1-(3,5-dimethoxy-4-acetylphenyl)-2-aminopropane

GINGER
1-(3-methoxy-4-acetylphenyl)-2-ethylaminopropane

GILLIGAN
1-(3-acetylphenyl)-2-aminopropane