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Ketamine salts solubility

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Fertile said:
Yes - The LogP is one of Lipinski's Rules of Five.

-No more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds)

-No more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms)

-A molecular mass less than 500 daltons

-A calculated octanol-water partition coefficient (Clog P) that does not exceed 5

And I think it was further refined to include:

-Not more than 5 rotatable bonds

There are a few variants but RO5 is exceptionally good at what it's supposed to do. It's VERY rare to find a drug that doesn't follow the rules. Calculating if a drug is ORALLY active is even more difficult.
Click to expand...
thanks man. See isn't it nice teaching people lol
 
I Would Like To Apologize To Fertile For Losing My Cool And Cussing him/her Out After Being Assailed Professionally ad hominem.

Also, Please Don't Post In This Thread Unless It Is Helpful, Or At Least Sanctioned. :)

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MIKE
1-phenyl-1-oxo-2-(1-pyrrolidinyl)propane

The Mike Stands 4 $$$$, And The D Is For Diamonds.

Mikey Likes It!
 
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DIRTY_SOUTH
1-(3,4-methylenedioxyphenyl)-1-oxo-2-(1-pyrrolidinyl)propane

Ya'll know who this is. Dirty South is where we live!!!
 
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fastandbulbous said:
The halogenated phosphorus compounds are the reason making methamphetamine from ephedrine/pseudoephedrine is practiced by hillbillies with no formal education in organic chemistry (red phosphorus & iodine form PI3, which replaces the OH group of ephedrine with an iodine group).
Click to expand...

IS it the PI3? I thought the PI3 was converted to HI? I know HI has been used, but maybe that has a different pathway. How one produces the HI has always been the 'pinch point' hence P4 being controlled. Oddly, the safer alternatives don't seem to be controlled.

The point is the same - don't mix a powerful halogenating agent with a moiety that is readily halogenated.
 
I Am On MIKE Now. This Is Day 3, Night 4. It Is A Gentle, Stellar Drug, But soft. Dose high. Go Air Force! My Skin Was noticeably paler and seemed well moisturized. I kind of have a headache now, but what do you expect? It is a long laster, For Sure. Possibly (probably?) A so Called Persistent Or Forever Chemical. Subtle. High frequency. High pitch. Relaxing. I'm still typing super fast now on Night 4. Usually even meth doesn't keep me up longer than Night 3. And I'm far from tired. MIKE will most likely go down in Pharmacologic history from here, but don't worry, I couldn't care less who, if anyone, gets the credit for it. If you make tight sh*t, n*ggaz will know your name! DIRTY_SOUTH is a must try. However, my unknown Chemical benefactor(s) do not let me test methylenedioxy Chemical, out of fear that they will stir me to undue homoeroticism, which is ridiculous because I am mad decent and barely have a dick to begin with. Ymmv. Oh, yeah. My name is PETER PARKER. ;) This Music is brand ass new and goes gr8 with MIKE. Ch Ch Ch eck It OUT!
 
I Got Freaks In The Bedroom Getting It On, And My Momma Ain't Home, So I'm Having A Party! Having A Party! Having A Party! Having A Party! Having A Party!

Sorry, Doc, But I BEEN Crazy! BEEN Crazy! BEEN Crazy! BEEN Crazy! BEEN Crazy!
 
Move In The Opposite Direction Than Your Competition. So If They Are Going Clockwise, You Go Counter Clockwise.

Imitation Is The Sincerist Form Of Flattery, But People Don't Like Being Copied And Need Their Space.
 
I Form Better, More Satisfying Relationships With Chemicals Than With People. And That's Ok! Chemophilia. It's Like Hemophilia Without AIDS. C. I'm Destitute, Not Prostitute.
 
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Carmen A Zavala, Ana C Thomaz, Vishakh Iyer, Ken Mackie, Andrea G Hohmann, Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression, Cannabis Cannabinoid Res 2021 Oct;6(5):389-400.


pubmed.ncbi.nlm.nih.gov

Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression - PubMed

<span><b>Introduction:</b> Overdose fatalities associated with the opioid epidemic are predictably attributable to drug-induced respiratory depression. In terms of illicit opioid abuse, fentanyl is the synthetic opioid responsible for the largest number of overdose deaths. There is, therefore...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

There's no obvious way to modify the structure of any of the known selective CB2 agonists to also make them bind to the mu opioid receptor at the same time, but AM-1241 is one compound where this looks like it could be possible. One theoretically possible risk is that you could be even more prone to opioid respiratory depression than normal for some time after quitting chronic cannabinoid use.
 
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CHRISTMAS
1-phenyl-(2S)-2-(1-pyrrolidinyl)propane

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NEW_YEAR'S
1-phenyl-(1R)-1-methoxy-(2S)-2-(1-pyrrolidinyl)propane
 
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ELMO
1-phenyl-(1R)-1-carbomethoxy-(2S)-2-(1-pyrrolidinyl)propane

ELMO may be too hard to make, but that kind of just depends on whom you ask.
 
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RETURN_OF_THE_GED_EYE
1-(3,4-methylenedioxyphenyl)-1-oxo-2-(1-pyrrolidinyl)propane

Good Enough Diploma

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CARRIE_FISCHER
1-(3,4-methylenedioxyphenyl)-2-(1-pyrrolidinyl)propane

Fischer Scientific

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THE_ANDROMEDAN
1-(3,4-methylenedioxyphenyl)-2-(1-pyrrolidinyl)-(1S)-1-methoxypropane

A Stranger In A Strange Land

The Andromeda Strain

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YEA_BUDDY
1-(3,4,5-trimethoxyphenyl)-2-(1-pyrrolidinyl)ethane


I just drew that last one because it looks so sexy. ;)
 
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YANKEE_DOODLE_DANDY_ANDY
(2R)-2-methyl-(3S)-3-phenylpyrrolidine

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OSO_ZOSO_SO_SO_TONE_DEF_LOCUS_POCUS_HOCUS_MOKUS
(2R)-2-methyl-(3S)-3-(4-methoxyphenyl)pyrrolidine

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PEW_WEE_HERMOSO_HERMAN_HAMBERGUESA
1-(3,5-dimethoxypyridin-4-yl)-2-aminopropane
 
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MAGNOLIANT
1-(4-heptyl-3,5-dimethoxyphenyl)-2-aminoethane

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STONED_CAPONE
3-(2-hydroxy-4-heptylphenyl)piperidine

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TRYPSORIL
1-(4-(methylthio)indole-3-yl)-2-dimethylaminoethane
 
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ENNIS
1-phenyl-(1S)-(methylthio)-2-(2S)-methylaminopropane

Probably, idk "funky"?
 
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SASHA
2-(4-oxa-1-azacyclohexyl)1-phenyl-1-oxo-propane

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COHEN
2-(4-oxa-1-azacyclohexyl)-1-phenylpropane
 
βK-a,n-Dmt aka beta keto n-methyl aMT
AKA tryptamethcathinone lol
N-Me-tryptalone.jpg


Can we say non - maoi triple monoamine releaser?

It's literally the tryptamine equivalent of methylone.
 
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