• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Ketamine reversing opioid tolerance

nznity

nznity

Bluelighter
Joined
Jan 24, 2017
Messages
7,947
Location
Lima.
ok so, i thought this wasn't possible or thougjt it didn't work until this past month i was clean. I did ketamine on 3 separate ocassions, just 50mg.doses IV. Fastforward 2 weeks AND i relapsed, my.typical dose was 100mg IV morphine. I did the same dose AND passed out ar my friends house. The next day i did 50mg.and it felt strong ASF. Then I've Been relapsing AND staying clean for afew days inbetween AND I've done k twice on the days off AND it helps reduce the tolerance so much . So it really works! Not only the painkilling fx but also the euphoria u get from the opiates. Ketamine Is a wonderful drug, anyone care to explain why this happens? Thx.in Advance. Nick(nzn)
 
Simply not using opioids for 2 weeks or more will remove most of the tolerance, even without ketamine. You should never take your earlier typical dose right away after being abstinent even for a couple of days.
 
polymath said:
Simply not using opioids for 2 weeks or more will remove most of the tolerance, even without ketamine. You should never take your earlier typical dose right away after being abstinent even for a couple of days.
Click to expand...
Ik but last Time i did the same, i was clean for the same AMT of Time AND had to take at least 80mg to feel high. This time it felt super strong. AND also the days I've Been using ketamine my tolerance has dropped significantly. I got high from 10mg today. Thst wouldve Been unimaginable even when i was 2 months clean 2 years ago.
 
Oh, the effect is real:

The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity.
NMDA and opioid receptors: their interactions in antinociception, tolerance and neuroplasticity.
(and dozens of other papers at pubmed)

I'm not really sure about how much is real tolerance reduction and how much is potentiation though. But there is a direct interaction between mu opioid and NMDA receptors for sure. And tolerance to NMDA antagonists is a bitch too. Semi-permanent.
 
I am a recovering heroin addict, with almost 4 years clean. I recently had 2 abdominal surgeries and requested that no opiates be given to me at the time of surgery or to be sent home with. The anesthesiologist that worked on me was very kind and understanding. We worked together on a plan for handling pain upon waking after surgery and he suggested giving me an IV dose of ketamine right before they woke me. I have had one other surgery since getting clean and waking up from that one was AWFUL. I was in horrible pain and highly agitated. But having them give me a dose of ketamine while waking up during this last surgery made everything tolorable. By the time I went home and the ketamine wore off I was in some pain (which is expected) but was able to get through it with just prescription doses of ibuprophen. I think that whether it is micro dosing ketamine therapy to help with addiction or using it as a substitute for opiates in the medical field, ketamine may turn out to be a great option for those in recovery.
 
Indeed - K IS a more effective analgesic than even the most potent opioid, but of course it has side-effects.
 
The same for the arylcyclohexylamine dissociatives. Don't take my word but for my personally I live better with the side effects of a dissociative than with morphine. That one wrecked me up badly, and yeah the antinociception is different.. opioids make pain tolerable. Dissociatives .. well, dissociative you from it. There is no pain.
 
You must log in or register to reply here.
Top