Misc Ketamine - recent papers

[jose ribas da silva]

Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex - Nature Communications

Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.

www.nature.com

 

[jose ribas da silva]

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites - Translational Psychiatry

Although the robust antidepressant effects of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in patients with treatment-resistant depression are beyond doubt, the precise molecular and cellular mechanisms underlying its antidepressant effects remain unknown. NMDAR inhibition and...

www.nature.com

 

[jose ribas da silva]

Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories - Nature Communications

Memories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in...

www.nature.com