Ketamine & Psychosis

[dingleberries]

I'm doing a critical review paper for a behavioural neuroscience subject at uni, and the area of study is schizophrenia. We were told to discuss possible causes for schizophrenia and its various symptoms. I chose to focus on ketamine mainly because of its psychotomimetic effects. What I am arguing is that although subanaesthetic doses of ketamine can produce many of the negative (and some positive?) symptoms of schizophrenia, these effects are temporary.
Does anyone know of any papers that investigate prolonged psychosis from ketamine use? Or for that matter, from other NMDA antagonists?

 

[fastandbulbous]

Try hunting for stuff on John Lilley, he had some prolonged bouts of ketamine use and came up with some unusual ideas that might give you something to start with (mad vs genius scientist).

 

[anhalonium9]

i found this interesting article which mentions K induced psychosis and schizophrenia under "Toxic Effects" about half way thru.

(BTW, i was addicted to ketamine in 1999. Feel free to e-mail me with any questions)

 

[Chuff]

I know several people who through long term K use developed mental health issues. I hope to return with more details next week....

 

[C6H6]

Prolonged administration of NMDA antagonists is a new and increasingly accepted animal model of schizophrenia.

Here's an interesting pub for you that essentially answers your question:
http://www.ncbi.nlm.nih.gov/entrez/...&dopt=Abstract&list_uids=15560968&query_hl=15

 

[BilZ0r]

Does anyone know of any papers that investigate prolonged psychosis from ketamine use? Or for that matter, from other NMDA antagonists?

No, i've never read anything like that, though as C6H6 showed, there are several groups which use NMDA antagonists as models for schizophrenia.